PHARMACEUTICAL PELLET MICROSPHERES

Pelletizing in pharmaceutical production

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Microspheres and pellets technology basics

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Technologies of pellet production and equipment used

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Pellets (microspheres) are obtained in several ways: direct pelletizing, pelletizing by rolling, pelletizing in a fluidized bed, pelletizing by layering. Pellets (microspheres) are obtained in several ways: direct pelletizing, pelletizing by rolling, pelletizing in a fluidized bed, pelletizing by layering. Direct pelletizing involves the creation of pellets directly from a powder with a binder or solvent. This is a fairly fast process that requires a small amount of excipients. In the initial stage, the powder is mixed and moistened. Then, if necessary, a solvent or binder is added, which are sprayed onto the powder particles. The powder layer is driven in a circular motion. As a result of the collisions and accelerations that occur in this case, agglomerates arise, which are rolled to obtain dense pellets of the correct spherical shape. The speed of rotation has a direct effect on the density and size of pellets. Then the wet pellets are dried in a fluidized bed. The advantage of the direct pelletizing method is to obtain round pellets with good fluidity, dosing, dispersibility, compact structure, high bulk weight, dense surface and high abrasion resistance.

Pelletizing by layering

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