PRODUCTION OF CREAMS AND OINTMENTS EQUIPMENT

Vacuum production unit for liquid and paste products

7824

6489437

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The German-Swiss company FrymaKoruma, part of the Romaco group of companies, is well known in the world market of pharmaceutical equipment. In Russia, the equipment of this company is also widely represented at many enterprises. In particular, at one of the leading Russian pharmaceutical enterprises JSC Akrikhin, the production of ointments and creams is carried out at the Disho installation of FrymaKoruma. Vacuum is a production plant for liquid and pasty products FrymaKoruma MaxxD, which has the same principle of operation as the Disho installation, but is a more modern development of the company. FrymaKoruma MaxxD is a modular system for the production of emulsions and suspensions with a wide range of viscosity. The main advantages of the plant are high production efficiency, reduced operating...

Hydrophilic bases for ointments and creams

7824

6489430

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Hydrophilic bases are mixed with water in any ratio. The following ointment bases are hydrophilic: solutions and gels of polysaccharides; solutions and gels of natural and synthetic polymers; phytosterol gels; gels of clay minerals; solutions and gels of proteins. The advantages of hydrophilic bases are: the possibility of introducing a significant amount of aqueous solutions of medicinal substances; ease of release of medicinal substances, which ensures their high bioavailability; good absorbency into the skin, the bases are easily removed from the application site and washed off with water from the skin. The disadvantages of hydrophilic bases include microbial contamination and rapid drying (this property does not apply to polyethylene oxides), as well as incompatibility with a number of medicinal substances and susceptibility to syneresis, a...

Homogenization of ointments and creams

7824

6489431

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The next stage in the production of ointments is homogenization. This is a specific stage, since when mixing, the desired degree of dispersion of medicinal substances is not always achieved. For homogenization, various equipment is used, such as roller or disc masers, millstones and colloidal mills, as well as homogenizers-dispersants. Roller mazeterki have two or three rolls with a smooth surface, rotating towards each other at different speeds, ensuring the transition of ointment from shaft to shaft and increasing the friction between them. Rolls are made of porcelain, basalt or metal. To maintain the optimal temperature of the ointment entering the rolls, they are made hollow so that, if necessary, water can be supplied inside. Mazeterka is a system of three rolls in contact with...

Hydrophobic bases

7824

6489435

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Hydrophobic, or lipophilic, bases are chemically heterogeneous substances and their mixtures with pronounced hydrophobicity. This group includes: fat bases; hydrocarbon bases; silicone bases. Fat bases include animal, vegetable and hydrogenated fats, as well as waxes. Animal fats by chemical nature are triglycerides of higher fatty acids. By their properties, they are close to the fatty secretions of the skin. In addition, fats contain unsaponifiable components, among which cholesterol predominates. Of animal fats, pork fat is the most common — Adeps suillus seu Axungiaporcina (depurata). It is a mixture of triglycerides of stearic, palmitic, oleic and linoleic acids. Pork fat also contains a small amount of cholesterol. It is a white mass almost odorless with a melting point of 34-36 "C. Ointments on pork fat are...