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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Introduction of medicine substances into the suppository base

Introduction of medicine substances into the suppository base

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Introduction of medicine substances into the suppository base

Introduction of medicine substances into the suppository base

There are three ways of introducing medicine into the suppository base, which are determined by the physical and chemical properties of the components: All water-soluble components are introduced in the form of aqueous solutions; fat-soluble substances are introduced in the form of fat solutions; substances insoluble in water and fat are introduced in the form of suspensions of powders melted into the bases. The resulting solutions or suspensions are called concentrates.

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  • Information updated : 07 / 02 / 2026
  • In stock
  • Manufacturer : 1 year for Introduction of medicine substances into the suppository base

Model: Suppository base

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Our service and customer service

The ready concentrate is pumped by a pump (through a hose with a capron sieve) into a reactor with a suppository base. Preparation of suppository mass is carried out with constant stirring and heating to a temperature of 45-50 ° C. At the end of the process, the product is analyzed for homogeneity of mixing of components, check the time of complete deformation, as well as the solidification and melting temperature of the mass. If positive results are obtained, the suppository mass is submitted for pouring into molds.

Pharmaceutical Glossary

Articles  — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.
Blog Business Business plan Buy a business Commerce Company Equipment catalog Innovation Investments Manufacture of suppositories Medications Medicinal substances Melting Analyzer Molding of suppositories Novelty Pharmaceutical equipment Preparation of suppository base Production Requirements for suppository bases Startup Suppository base Suppository line

Technical specifications

At the stage of medicine preparation, water-soluble components are dissolved in water heated to 45 ° C, and fat-soluble components are dissolved in a portion of the melted fat base. The resulting concentrates are filtered and then mixed with the remaining base. Substances insoluble in water and base, introduced in the form of suspension as follows: pre-crushed medicine substances mixed in a reactor with an equal or one and a half times the amount of base, heated to a temperature of 40-50 ° C.

Additional information

The obtained concentrate is cooled and milled in colloid mills. For treatment of thermolabile substances three-roll masheters are used. In addition, to obtain high-quality suspensions can be used rotary-pulsation devices, rotary-tooth pumps and other equipment. To obtain the required degree of dispersibility of the medicine substance introduced into the base on the type of suspension, the time of rubbing the concentrate lasts from 2 to 4 h.

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