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Thus, the new technology of fluidized bed encapsulation under supercritical conditions allows coating thermolabile materials with particle sizes not exceeding 100 μm without particle agglomeration. The technology is increasingly being introduced into modern pharmaceutical production and requires further study to obtain effective and safe new generation drugs. Nowadays, the encapsulation process has gained new development due to the possibility of changing the pharmacological properties of drugs and the development of innovative equipment. Solid, soft and liquid active drug substances can be encapsulated in different types of shells, so this material is highlighted in a separate chapter.
Pharmaceutical Glossary
Technical specifications
This feature allows particles smaller than 100 µm to be encapsulated in the fluidized bed without forming agglomerates. At the same time supercritical fluid is used both as a solvent for the dispersed solution and as a fluidizing agent. This unit consists of three blocks: carbon dioxide supply system; extractor, in which carbon dioxide saturation with coating material takes place; high-pressure reactor. The volume of the reactor is 500 cm3; the maximum pressure in the system is 30 MPa, the maximum temperature is 373 °C. Prior to the process, the reactor is loaded with encapsulated material.
Additional information
For fluidization of the particle bed, pure carbon dioxide is fed from the bottom of the apparatus through the perforated bottom. It is experimentally confirmed that with increasing pressure in the system the minimum fluidization rate decreases. The encapsulation process starts after thermal equilibrium is established in the reactor. The carbon dioxide passes through an extractor where it is saturated with the coating agent and dispersed by a nozzle in the reactor. The dispersion results in submicron-sized droplets that settle on the surface of the particles and spread to form a thin film. After coating, the particles are allowed to dry.
Order status tracking
RZW-29 rotary tablet press in Oslo. Regards, James. 09/07/2025 22:51
James, Delivery will be made in the interval from 14:00-16:00 to Oslo . Please have the movers ready. The weight of the equipment is heavy. 09/07/2025 22:52
Good day, delivery time of semi-automatic drum filling machine DF-10 to Oxford, will the courier call us? 09/07/2025 23:01
Nova, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 09/07/2025 23:03
Horizontal granulator for organic fertilizers JU-80, the price is up to date ? Delivery time to Geneva? Urgent. 09/07/2025 23:11
Oliver, Please read carefully the description of this model in our catalog. Prices are current. Timing 1-1.5 months. 09/07/2025 23:13
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Budapest ? 09/07/2025 23:21
Hello Aria, your shipment is in the customs warehouse, tomorrow until 12:30 your manager Natalia will contact you. 09/07/2025 23:24
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled tomorrow until 13:30 to open the box and test. 09/07/2025 23:31
Evelyn, good afternoon. Great news, please send a photo and video report to WhatsApp +79853643808. 09/07/2025 23:34
Waiting for delivery to Marburg of a TR-02 hard gelatin capsule polishing machine. What about it? 09/07/2025 23:41
Hello Alexander, on your order we inform you that between 16:00-18:00 the driver will contact you to clarify the time and place of unloading. 09/07/2025 23:44
We received our order (BG-150 film coating boiler) in the box there was no spraying nozzle !!! 09/07/2025 23:51
Hello Hannah, we checked with the factory. Your nozzle was not received in time for the shipment of the main machine. We will now deliver it to you by DHL express mail. 09/07/2025 23:54
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 10/07/2025 00:01
Hello Aubrey, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 10/07/2025 00:05
Today we were promised delivery of a blister machine for MN-14 tablets and capsules, remember us ? No one's called us back. 10/07/2025 00:11
Hello Daniel, Our manager Natalya in the interval from 10:00-12:00 will dial the driver, also we ask you yourself to the transportation company. 10/07/2025 00:15
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Vienna ? 10/07/2025 00:21
Hello Lily, your shipment is in the customs warehouse, In the afternoon your manager Natalia will contact you. 10/07/2025 00:22
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR COATING TABLETS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COATING TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- PERISTALTIC PUMPS DISPENSERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION