СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / FILM-COATING OF TABLETS / Encapsulation by fluidized bed coating method

Encapsulation by fluidized bed coating method

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / FILM-COATING OF TABLETS / Encapsulation by fluidized bed coating method

Encapsulation by fluidized bed coating method

Fluidized bed coating of fine particles at supercritical conditions is a new emerging technology for the encapsulation of thermolabile products. Supercritical fluids are unique solvents because their densities are similar to those of liquids, while viscosity and diffusion coefficient are close to these values for gases. Atomization of supercritical solutions allows the production of submicron-sized droplets and particles, as well as sputtering on and on, other particles. Since the cohesive and adhesive forces for supercritical solutions are small compared to those for organic solvents, the capillary compression force is negligible.

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Information updated : 11 / 01 / 2026
In stock
Manufacturer : 1 year for Encapsulation by fluidized bed coating method

Model: Encapsulation

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Thus, the new technology of fluidized bed encapsulation under supercritical conditions allows coating thermolabile materials with particle sizes not exceeding 100 μm without particle agglomeration. The technology is increasingly being introduced into modern pharmaceutical production and requires further study to obtain effective and safe new generation drugs. Nowadays, the encapsulation process has gained new development due to the possibility of changing the pharmacological properties of drugs and the development of innovative equipment. Solid, soft and liquid active drug substances can be encapsulated in different types of shells, so this material is highlighted in a separate chapter.

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Technical specifications

This feature allows particles smaller than 100 µm to be encapsulated in the fluidized bed without forming agglomerates. At the same time supercritical fluid is used both as a solvent for the dispersed solution and as a fluidizing agent. This unit consists of three blocks: carbon dioxide supply system; extractor, in which carbon dioxide saturation with coating material takes place; high-pressure reactor. The volume of the reactor is 500 cm3; the maximum pressure in the system is 30 MPa, the maximum temperature is 373 °C. Prior to the process, the reactor is loaded with encapsulated material.

Additional information

For fluidization of the particle bed, pure carbon dioxide is fed from the bottom of the apparatus through the perforated bottom. It is experimentally confirmed that with increasing pressure in the system the minimum fluidization rate decreases. The encapsulation process starts after thermal equilibrium is established in the reactor. The carbon dioxide passes through an extractor where it is saturated with the coating agent and dispersed by a nozzle in the reactor. The dispersion results in submicron-sized droplets that settle on the surface of the particles and spread to form a thin film. After coating, the particles are allowed to dry.

Order status tracking

Roman Tsibulsky +79853643808 now online

Muhammad
When purchasing the RY-200 centrifugal type powder granulator, I asked for tests on our powder 30/01/2026 06:03

Roman Tsibulsky
Hello Muhammad, Please send 2 kg of your raw material to the address given to you by Natalia. After the test, the engineer will inform you about the results. 30/01/2026 06:04

Oliver
Good day, delivery time of semi-automatic drum filling machine DF-10 to Cavala, will the courier call us? 30/01/2026 06:13

Roman Tsibulsky
Oliver, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 30/01/2026 06:14

James
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 30/01/2026 06:23

Roman Tsibulsky
James, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Oakland ? Contact Natalia, she will send the contract and invoice. 30/01/2026 06:24

Dylan
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 30/01/2026 06:33

Roman Tsibulsky
Hello Dylan, Our manager Natalia tomorrow until 16:30 will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Mariehamn in 15 days. 30/01/2026 06:36

Ethan
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Lisbon, do you deliver to the terminal or to the actual address? 30/01/2026 06:43

Roman Tsibulsky
Hello Ethan, we ship all over Europe and the US including to Lisbon . The price in the catalog includes any delivery our customer asks for. 30/01/2026 06:47

Aurora
Can your technician come to Frankfurt? We need technologist consultation and assistance. 30/01/2026 06:53

Roman Tsibulsky
Aurora, We have already received your email. A technician tomorrow until 12:30 will contact you. Don't worry. 30/01/2026 06:54

Emma
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Stockholm, do you deliver to the terminal or to the actual address? 30/01/2026 07:03

Roman Tsibulsky
Hello Emma, we ship all over Europe and the US including to Stockholm . The price in the catalog includes any delivery our customer asks for. 30/01/2026 07:05

Dylan
Today we were promised delivery of a blister machine for MN-14 tablets and capsules, remember us ? No one's called us back. 30/01/2026 07:13

Roman Tsibulsky
Hello Dylan, Our manager Natalya as stipulated in the contract will dial the driver, also we ask you yourself to the transportation company. 30/01/2026 07:16

Samuel
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 30/01/2026 07:23

Roman Tsibulsky
Samuel, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer before lunch. We will report back immediately. 30/01/2026 07:24

Owen
Contract #12, the deadline for delivery has already passed. Take action at last. Accelerate Tsibulsky R.G. 30/01/2026 07:33

Roman Tsibulsky
Hello Owen, we are on vacation on weekends and are not able to respond to messages. Raise the contract, delivery time of equipment to your warehouse in Luxembourg City to 50 working ( not calendar) days. Action taken. 30/01/2026 07:36