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Granulation of a mixture of drug and excipients using a portion of the binder solution followed by the addition of the remaining dry binder to the finished granular material. There are a number of factors that determine which method should be used. For many formulations, method 1 produces tablets with a faster disintegration time and faster drug release than method 2. In many cases, Method 1 results in slightly harder tablets than Method 2. Method 3 is used when Method 1 cannot be used (e.g., when the tabletting mixture cannot absorb the required amount of liquid). In case of difficulties related to disintegration time, Method 4 is recommended.
Pharmaceutical Glossary
Technical specifications
In order for the powder to granulate, it must be moistened to a certain degree. For this purpose, the powders are mixed with granulating liquids. The optimum amount of humectant is determined experimentally (based on the physical and chemical properties of the powders) and specified in the regulations. If there is not enough humectant, the granules will crumble after drying, if there is a lot of humectant, the mass will be viscous, sticky and poorly granulated. A mass with optimum moisture content is a moist, dense mixture that does not stick to the hand, but crumbles into individual lumps when squeezed. Binders are necessary to bind the powder particles and prevent surface disruption of the finished tablets, i.e. to increase the strength of the tablets and their resistance to fracture. The binder (granulating) liquid hits the solid powder particles, wetting them and forming liquid “bridges”.
Additional information
During dehydration of the mixture of active and auxiliary substances with granulating liquid, the binding liquid “bridges” gradually turn into solid “bridges” and as a result agglomerates (final granules having the structure of a “snowball”) are formed. Particles are brought together by molecular, electrostatic and capillary forces. The formation of “bridges” can occur through chemical reactions. Wet granulation remains the most widely used method for the manufacture of tablet mixtures. There are at least four different variations of the method: Granulation of drug and excipient mixtures using a binder solution. Granulation of drug and excipient mixture with binder and pure solvent.
Granulation of a mixture of drug and excipients and part of the binder using a solution of the remaining binder.
Order status tracking
Today we were promised delivery of a blister machine for MN-14 tablets and capsules, remember us ? No one's called us back. 22/07/2024 04:05
Hello Bella, Our manager Natalya between 16:00-18:00 will dial the driver, also we ask you yourself to the transportation company. 22/07/2024 04:07
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 22/07/2024 04:15
Hello Layla, Our manager Natalia in the interval from 14:00-16:00 will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Toledo in 15 days. 22/07/2024 04:16
Tell me the NJ-120 automatic capsule machine went ? 22/07/2024 04:25
Matthew, good afternoon. Yes, already tomorrow until 16:30 you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 22/07/2024 04:28
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled in the interval from 14:00-16:00 to open the box and test. 22/07/2024 04:35
Aria, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 22/07/2024 04:38
RZW-29 rotary tablet press in Istanbul. Regards, Logan. 22/07/2024 04:45
Logan, Delivery will be made tomorrow by lunchtime to Istanbul . Please have the movers ready. The weight of the equipment is heavy. 22/07/2024 04:49
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 22/07/2024 04:55
Hello Matthew, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 22/07/2024 04:57
Can your technician come to Geneva? We need technologist consultation and assistance. 22/07/2024 05:05
Sebastian, We have already received your email. A technician tomorrow until 18: 30 will contact you. Don't worry. 22/07/2024 05:06
To what address to send you samples of bottles and caps to send them to the factory ? Regards Jackson. 22/07/2024 05:15
Good day, Jackson We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 22/07/2024 05:16
Horizontal granulator for organic fertilizers JU-80, the price is up to date ? Delivery time to Strasbourg? Urgent. 22/07/2024 05:25
Wyatt, Please read carefully the description of this model in our catalog. Prices are current. Timing 1-1.5 months. 22/07/2024 05:28
Good day, I want tomorrow until 13:30 to get FF-02 tablet and capsule filling machine in USA? 22/07/2024 05:35
Good afternoon, Mia! We have contacted the transportation company, your shipment is arriving in USA without delay. Please wait for a call from a representative of Business Lines. 22/07/2024 05:38
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- PERISTALTIC PUMPS DISPENSERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING