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Granulation of a mixture of drug and excipients using a portion of the binder solution followed by the addition of the remaining dry binder to the finished granular material. There are a number of factors that determine which method should be used. For many formulations, method 1 produces tablets with a faster disintegration time and faster drug release than method 2. In many cases, Method 1 results in slightly harder tablets than Method 2. Method 3 is used when Method 1 cannot be used (e.g., when the tabletting mixture cannot absorb the required amount of liquid). In case of difficulties related to disintegration time, Method 4 is recommended.
Pharmaceutical Glossary
Technical specifications
In order for the powder to granulate, it must be moistened to a certain degree. For this purpose, the powders are mixed with granulating liquids. The optimum amount of humectant is determined experimentally (based on the physical and chemical properties of the powders) and specified in the regulations. If there is not enough humectant, the granules will crumble after drying, if there is a lot of humectant, the mass will be viscous, sticky and poorly granulated. A mass with optimum moisture content is a moist, dense mixture that does not stick to the hand, but crumbles into individual lumps when squeezed. Binders are necessary to bind the powder particles and prevent surface disruption of the finished tablets, i.e. to increase the strength of the tablets and their resistance to fracture. The binder (granulating) liquid hits the solid powder particles, wetting them and forming liquid “bridges”.
Additional information
During dehydration of the mixture of active and auxiliary substances with granulating liquid, the binding liquid “bridges” gradually turn into solid “bridges” and as a result agglomerates (final granules having the structure of a “snowball”) are formed. Particles are brought together by molecular, electrostatic and capillary forces. The formation of “bridges” can occur through chemical reactions. Wet granulation remains the most widely used method for the manufacture of tablet mixtures. There are at least four different variations of the method: Granulation of drug and excipient mixtures using a binder solution. Granulation of drug and excipient mixture with binder and pure solvent.
Granulation of a mixture of drug and excipients and part of the binder using a solution of the remaining binder.
Order status tracking
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to Colorado Springs. Thank you. 18/05/2025 16:32
Samuel, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to Colorado Springs is scheduled for closer to evening. Please notify us upon receipt. 18/05/2025 16:35
LW-35 automatic PVC+cardboard blister packaging machine has been on the road for 30 days. What news ? 18/05/2025 16:42
Hello David, We are on time, tomorrow until 13:30 a driver will contact you about unloading. 18/05/2025 16:44
Vacuum powder conveyor QV-01 quantity of 3 pieces, need discount and delivery to Austin. 18/05/2025 16:52
Good day David, in our catalog all prices are given including delivery to the door of the customer. If you buy 3 pieces we will make a discount of 7%. Delivery to Austin is included in the price. 18/05/2025 16:54
How to contact you for shipment tracking ? Industrial vibrating screen VS-04. 18/05/2025 17:02
Good afternoon, Muhammad, My WhastApp is +79853643808, Manager Natalia +79153808881 during business hours and except weekends. 18/05/2025 17:05
Today we were promised delivery of a blister machine for MN-14 tablets and capsules, remember us ? No one's called us back. 18/05/2025 17:12
Hello Samuel, Our manager Natalya after lunch will dial the driver, also we ask you yourself to the transportation company. 18/05/2025 17:14
You have to pay for delivery to Lucca over and above the delivery amount in the contract ? 18/05/2025 17:22
Andrew, The catalog shows the price with door delivery. The unloading of the equipment, upon receipt of the shipment, will be charged to you separately. 18/05/2025 17:24
Remember me? There's a delivery in the Frankfurt 18/05/2025 17:32
Elijah, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be the day after tomorrow in Frankfurt . 18/05/2025 17:35
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Reykjavik, do you deliver to the terminal or to the actual address? 18/05/2025 17:42
Hello Ella, we deliver all over USA including to Reykjavik . The price in the catalog includes any delivery our customer asks for. 18/05/2025 17:42
Remember me? There's a delivery in the Tbilisi 18/05/2025 17:52
Natalie, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be tomorrow by lunchtime in Tbilisi . 18/05/2025 17:55
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Brussels ? 18/05/2025 18:02
Hello Mia, Expect in the interval from 14:00-16:00. Once received, please let us know. 18/05/2025 18:05
- BOTTLE FILLING AND CAPPING EQUIPMENT
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS