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Abroad, polyethylene glycol bases are known as “Carbovax” (USA), “Scourol” (France), “Postonal”, “Suppopharm” (Germany and Scandinavian countries). This group of bases is able to dissolve in the secretions of mucous membranes, fully release medecine substances without irritating the mucosa. These bases have a long shelf life, high physiologic indifference and relatively affordable cost. Gelatin-glycerin and soap-glycerin bases are much less frequently used in the manufacture of suppositories, although they are included in the pharmacopoeias of a number of countries around the world. The following requirements are imposed on hydrophilic suppository bases: to dissolve quickly and completely in the secretions of mucous membranes; not to irritate the mucosa; to mix with hydrophobic medecine substances or absorb them; to be chemically and pharmacologically indifferent.
For suppositories made on hydrophilic bases, determine the dissolution time. To do this, one suppository is placed at the bottom of a vessel with a capacity of 100 ml, containing 50 ml of water with a temperature of (37±1) °C. Every 5 min the vessel is shaken so that the liquid and the sample acquire rotational motion. The suppository should dissolve within 1h. To ensure optimal structural and mechanical characteristics of suppository bases to them add stearates of aluminum, magnesium and other salts of fatty acids, as well as emulsifiers T-1, T-2 and №1, bentonite, glucose, starch, aerosil and other auxiliary substances approved for medical use.
Pharmaceutical Glossary
Technical specifications
Closely related to these general requirements and technological requirements for bases, which should: show chemical and physical stability in the process of manufacture and storage of suppositories, easily molded and retain the necessary hardness during insertion, have the ability to emulsify the required amount of solutions, have a certain plasticity, viscosity, deformation time and structural and mechanical properties. These technological requirements are met by lipophilic, hydrophilic bases and their mixtures used in the pharmaceutical industry in different countries of the world. As lipophilic suppository bases State Pharmacopoeia USSR XI recommends using cocoa butter, its alloys with paraffin and hydro-genated fats, vegetable and animal fats, solid fat, lanol, alloys of fats with wax and solid paraffin. Currently, cocoa butter remains the official pharmacopoeial base in the pharmacopoeias of a number of countries. Lipophilic bases should meet the following requirements: quickly melt in the rectum, have a melting point not higher than 37 ° C, have sufficient hardness and a small difference between the melting and solidification temperatures, have sufficient viscosity, absorb liquids well, be stable during storage.
Additional information
Due to the fact that the melting points of the base components fluctuate within a fairly wide range (hydrofat – from 28 to 37 ° C, paraffin – from 50 to 57 ° C, cocoa butter – from 30 to 34 ° C), the actual melting point of the resulting alloy may be slightly higher or lower than the specified temperature. In this case, paraffin or hydrofat is added to the base in the amounts necessary to bring the melting temperature of the mixture to the specified value. In this case, use the “table of additives”. In addition to the required melting point, suppository base should also have appropriate structural and mechanical properties. They can be judged by the time of total deformation of the suppository prepared from this base. Determination of the time of full deformation is carried out at a temperature of 37 ° C on the device Kruvchinsky. In the composition of bases are often introduced surfactants, which not only improve the structural and mechanical properties, but also affect the kinetics of release and absorption of medecine. Hydrophilic suppository bases are mainly represented by polyethylene glycols (polyethylene oxides) – condensed polymers of ethylene oxide and water. Domestic industry produces polyethylene glycols differing in molecular weight: PEO-400, PEO-1500, PEO-2000, PEO-4000 and PEO-6000.
Order status tracking
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Prague ? 22/07/2024 06:13
Hello Layla, your shipment is in the customs warehouse, the day after tomorrow your manager Natalia will contact you. 22/07/2024 06:17
Good afternoon, I am hoping tomorrow until 16:30 to get the UNIC 600A Tablet Press in Figueres ! Please comment. 22/07/2024 06:23
Good day, Luna! Our manager has communicated with the delivery service, the equipment will be delivered to Figueres at your address. Please let us know when you receive it. 22/07/2024 06:24
Horizontal granulator for organic fertilizers JU-80, the price is up to date ? Delivery time to Bruges? Urgent. 22/07/2024 06:33
Sebastian, Please read carefully the description of this model in our catalog. Prices are current. Timing 1-1.5 months. 22/07/2024 06:37
Good afternoon! semi-automatic liquid filling machine in barrels DF-13 , a copy of the payment is sent to the post. Start the order to work. 22/07/2024 06:43
Victoria, good afternoon! We have seen your payment, we receive SMS from the bank. Please send drawings of barrels and answers to our questions in correspondence. 22/07/2024 06:46
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in New Orleans 22/07/2024 06:53
Hello Scarlett, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 22/07/2024 06:54
To what address to send you samples of bottles and caps to send them to the factory ? Regards Harper. 22/07/2024 07:03
Good day, Harper We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 22/07/2024 07:05
PU-250 flow-pack packaging machine, please advise delivery status. 22/07/2024 07:13
Hello Aurora, your equipment is undergoing customs clearance. Your manager Natalia will contact you closer to evening 22/07/2024 07:15
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to York, do you deliver to the terminal or to the actual address? 22/07/2024 07:23
Hello Ethan, we ship all over Europe and the US including to York . The price in the catalog includes any delivery our customer asks for. 22/07/2024 07:24
Roman, can you tell me if my rotary tablet press RZJ-35 has been shipped yet? Don't send it yet, I will send to your factory in China drawings of new punches, different design. 22/07/2024 07:33
Good afternoon, Jackson! We're pausing the shipment. Send drawings to the office mail. The terms of production of new punches 20 working days. 22/07/2024 07:36
You have to pay for delivery to Butrint over and above the delivery amount in the contract ? 22/07/2024 07:43
Mia, The catalog shows the price with door delivery. The unloading of the equipment, upon receipt of the shipment, will be charged to you separately. 22/07/2024 07:44
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS