Video review of the model
Our service and customer service
At the same time, they can be used to identify the dosage form. Additionally, some physical properties of the coating, such as moisture resistance, can be improved with dyes. Dyes can be classified into water-soluble dyes and insoluble pigments.
Water-soluble dyes cannot be used in film coatings based on organic solvents, they can only be used in coatings based on aqueous compositions. Pigments are preferred because: they are less likely to affect bioavailability than some water-soluble colorants; they help reduce the water permeability of the coating; and they can be used as fillers to increase the total solid content of the coating dispersion without undesirable increases in viscosity. Solvents. Solvents for film coatings may include: alcohols, ketones, esters, chlorinated hydrocarbons and water. Solvents have an important function in the coating formation process as they help in coating the core surface. A good interaction between the solvent and the polymer is necessary to ensure optimum film properties when the coating dries. This initial interaction between solvent and polymer will maximize the elongation of the polymer chain, which in turn will provide good cohesive strength and thus the best mechanical properties. At the same time, an important function of the solvent system is to provide a controlled distribution of the polymer on the core surface to create a homogeneous coating.
Pharmaceutical Glossary
Technical specifications
Studies have shown that when the HPMC content in the blend is less than 24%, the release profile depends on the rate of water penetration into the coating, which in turn becomes a determining factor in selecting the ratio of polymer concentrations in the blend.
Most of the polymers used are available in a wide range of molecular weights, which is a major factor in the choice of coating technology. Molecular weight can have a significant effect on coating properties such as viscosity, mechanical strength, and film elasticity.
Plasticizers. A plasticizer is a liquid or solid with a high boiling point. Examples of plasticizers include glycerin, propylene glycol, polyethylene glycol, triacetin, esters of citric acid (e.g., triethyl citrate), esters of phthalic acid (e.g., triethyl phthalate). The introduction of a plasticizer can improve the elasticity of the coating Cracking the risk of mechanical damage and potentially in the coating improve the adhesion of the film coating to the core.
When the plasticizer interacts with the polymer, the minimum film formation temperature may be reduced. To form a quality film, the plasticizer must have high compatibility with the polymer and be permanently retained in the coating, especially if the main objective of the coating is the stability of the dosage form during storage.
Additional information
The scientific literature provides numerous examples of the effect of plasticizer concentration on the physicochemical properties of the film coating and on the release of the drug substance from the coated products. For example, high plasticizer content can reduce the release of metoprolol from Eudragit RS coated microspheres and improve the release stability of theophylline from coated microspheres during storage.
Moreover, the release rate of the drug substance has been shown to be influenced by the type of plasticizer. For example, the release of propanolol from microspheres coated with a mixture of ethylcellulose and Eudragit L100-55 is faster when using the hydrophilic plasticizer triethyl citrate than when using the hydrophobic dibutyl sebacinate. Other studies have shown that the plasticizer can leach out of the coating during dissolution, thus affecting both mechanical properties and the release of LVs.
Adhesion of coating substances during film application causes the formation of undesirable aggregates, and the resulting coatings may be damaged when attempts are made to separate adhering parts. This effect can be neutralized by adding anti-adhesion agents to the coating composition or by applying these agents immediately after the spray chamber. Useful anti-adhesion agents include talc, magnesium stearate, kaolin, etc.
Dyes. Dyes are commonly used to improve the appearance of the dosage form.
Order status tracking
PU-250 flow-pack packaging machine, please advise delivery status. 02/04/2025 05:00
Hello Liam, your equipment is undergoing customs clearance. Your manager Natalia will contact you In the afternoon 02/04/2025 05:00
Hello, is it possible to buy your blistering machine for tablets and capsules MN-80 1 piece with delivery to El Paso ( Europe) ? How much time for delivery ? 02/04/2025 05:10
Muhammad, hello! We have many customers from your city. Delivery to this region is made by EMC. 02/04/2025 05:11
Waiting for delivery to Bonifacio of a TR-02 hard gelatin capsule polishing machine. What about it? 02/04/2025 05:20
Hello Sofia, on your order we inform you that between 16:00-18:00 the driver will contact you to clarify the time and place of unloading. 02/04/2025 05:23
PU-250 flow-pack packaging machine, please advise delivery status. 02/04/2025 05:30
Hello Andrew, your equipment is undergoing customs clearance. Your manager Natalia will contact you as stipulated in the contract 02/04/2025 05:31
Run through the order. V-shaped mixer for powders VM-50 and Mechanical tablet press PP-28 are waiting. 02/04/2025 05:40
Savannah, Checking delivery status. The shipment is already in Prague warehouse. Please arrange for pickup. 02/04/2025 05:43
We're from New Jersey, we paid for the equipment on your invoice yesterday. Has the payment been received? How long will it take to deliver to us? 02/04/2025 05:50
Evelyn, hello. Payment is credited to our settlement account. Term of manufacture of your equipment by the factory 20 working days, delivery from the factory to our warehouse in the USA 1 month, delivery from the warehouse in Oklahoma City 15 calendar days. 02/04/2025 05:53
Please inform me about the status of the order Rotary tablet press RZ-10A in Kansas City ? 02/04/2025 06:00
Good afternoon, Aurora. We have contacted the carrier, delivery is scheduled before lunch. Please let us know when you receive it. Thank you. 02/04/2025 06:03
The MZ-10 expiration date and date handheld printer has still not been delivered. The driver did not answer and dropped calls yesterday. 02/04/2025 06:10
Hello Riley, Transportation has advised that after lunch driver will definitely deliver the box to your address. We apologize. 02/04/2025 06:12
Good afternoon, please confirm that tomorrow until 16:30 we will receive our shipment in Paris? Contact the transportation company. 02/04/2025 06:20
Hello Elijah ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Paris in a few days. Please expect it. 02/04/2025 06:22
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 02/04/2025 06:30
Liam, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer as agreed. We will report back immediately. 02/04/2025 06:30
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING