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At the same time, they can be used to identify the dosage form. Additionally, some physical properties of the coating, such as moisture resistance, can be improved with dyes. Dyes can be classified into water-soluble dyes and insoluble pigments.
Water-soluble dyes cannot be used in film coatings based on organic solvents, they can only be used in coatings based on aqueous compositions. Pigments are preferred because: they are less likely to affect bioavailability than some water-soluble colorants; they help reduce the water permeability of the coating; and they can be used as fillers to increase the total solid content of the coating dispersion without undesirable increases in viscosity. Solvents. Solvents for film coatings may include: alcohols, ketones, esters, chlorinated hydrocarbons and water. Solvents have an important function in the coating formation process as they help in coating the core surface. A good interaction between the solvent and the polymer is necessary to ensure optimum film properties when the coating dries. This initial interaction between solvent and polymer will maximize the elongation of the polymer chain, which in turn will provide good cohesive strength and thus the best mechanical properties. At the same time, an important function of the solvent system is to provide a controlled distribution of the polymer on the core surface to create a homogeneous coating.
Pharmaceutical Glossary
Technical specifications
Studies have shown that when the HPMC content in the blend is less than 24%, the release profile depends on the rate of water penetration into the coating, which in turn becomes a determining factor in selecting the ratio of polymer concentrations in the blend.
Most of the polymers used are available in a wide range of molecular weights, which is a major factor in the choice of coating technology. Molecular weight can have a significant effect on coating properties such as viscosity, mechanical strength, and film elasticity.
Plasticizers. A plasticizer is a liquid or solid with a high boiling point. Examples of plasticizers include glycerin, propylene glycol, polyethylene glycol, triacetin, esters of citric acid (e.g., triethyl citrate), esters of phthalic acid (e.g., triethyl phthalate). The introduction of a plasticizer can improve the elasticity of the coating Cracking the risk of mechanical damage and potentially in the coating improve the adhesion of the film coating to the core.
When the plasticizer interacts with the polymer, the minimum film formation temperature may be reduced. To form a quality film, the plasticizer must have high compatibility with the polymer and be permanently retained in the coating, especially if the main objective of the coating is the stability of the dosage form during storage.
Additional information
The scientific literature provides numerous examples of the effect of plasticizer concentration on the physicochemical properties of the film coating and on the release of the drug substance from the coated products. For example, high plasticizer content can reduce the release of metoprolol from Eudragit RS coated microspheres and improve the release stability of theophylline from coated microspheres during storage.
Moreover, the release rate of the drug substance has been shown to be influenced by the type of plasticizer. For example, the release of propanolol from microspheres coated with a mixture of ethylcellulose and Eudragit L100-55 is faster when using the hydrophilic plasticizer triethyl citrate than when using the hydrophobic dibutyl sebacinate. Other studies have shown that the plasticizer can leach out of the coating during dissolution, thus affecting both mechanical properties and the release of LVs.
Adhesion of coating substances during film application causes the formation of undesirable aggregates, and the resulting coatings may be damaged when attempts are made to separate adhering parts. This effect can be neutralized by adding anti-adhesion agents to the coating composition or by applying these agents immediately after the spray chamber. Useful anti-adhesion agents include talc, magnesium stearate, kaolin, etc.
Dyes. Dyes are commonly used to improve the appearance of the dosage form.
Order status tracking
Good afternoon, I am hoping tomorrow until 13:30 to get the UNIC 600A Tablet Press in St. Gallen ! Please comment. 10/06/2025 01:28
Good day, James! Our manager has communicated with the delivery service, the equipment will be delivered to St. Gallen at your address. Please let us know when you receive it. 10/06/2025 01:28
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 10/06/2025 01:38
Hello Henry, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 10/06/2025 01:42
You have to pay for delivery to Plovdiv over and above the delivery amount in the contract ? 10/06/2025 01:48
Emilia, The catalog shows the price with door delivery. The unloading of the equipment, upon receipt of the shipment, will be charged to you separately. 10/06/2025 01:52
Vacuum powder conveyor QV-01 quantity of 3 pieces, need discount and delivery to Omaha. 10/06/2025 01:58
Good day Sophia, in our catalog all prices are given including delivery to the door of the customer. If you buy 3 pieces we will make a discount of 7%. Delivery to Omaha is included in the price. 10/06/2025 02:01
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in Denver 10/06/2025 02:08
Hello Joseph, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 10/06/2025 02:10
Good day, delivery time of semi-automatic drum filling machine DF-10 to Split, will the courier call us? 10/06/2025 02:18
Emily, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 10/06/2025 02:21
Tell me the NJ-120 automatic capsule machine went ? 10/06/2025 02:28
Joseph, good afternoon. Yes, already tomorrow until 12:30 you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 10/06/2025 02:31
The MZ-10 expiration date and date handheld printer has still not been delivered. The driver did not answer and dropped calls yesterday. 10/06/2025 02:38
Hello Mia, Transportation has advised that tomorrow until 14:30 driver will definitely deliver the box to your address. We apologize. 10/06/2025 02:40
PU-250 flow-pack packaging machine, please advise delivery status. 10/06/2025 02:48
Hello Samuel, your equipment is undergoing customs clearance. Your manager Natalia will contact you in the morning 10/06/2025 02:49
Good afternoon! semi-automatic liquid filling machine in barrels DF-13 , a copy of the payment is sent to the post. Start the order to work. 10/06/2025 02:58
John, good afternoon! We have seen your payment, we receive SMS from the bank. Please send drawings of barrels and answers to our questions in correspondence. 10/06/2025 02:58
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- PERISTALTIC PUMPS DISPENSERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER