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At the same time, they can be used to identify the dosage form. Additionally, some physical properties of the coating, such as moisture resistance, can be improved with dyes. Dyes can be classified into water-soluble dyes and insoluble pigments.
Water-soluble dyes cannot be used in film coatings based on organic solvents, they can only be used in coatings based on aqueous compositions. Pigments are preferred because: they are less likely to affect bioavailability than some water-soluble colorants; they help reduce the water permeability of the coating; and they can be used as fillers to increase the total solid content of the coating dispersion without undesirable increases in viscosity. Solvents. Solvents for film coatings may include: alcohols, ketones, esters, chlorinated hydrocarbons and water. Solvents have an important function in the coating formation process as they help in coating the core surface. A good interaction between the solvent and the polymer is necessary to ensure optimum film properties when the coating dries. This initial interaction between solvent and polymer will maximize the elongation of the polymer chain, which in turn will provide good cohesive strength and thus the best mechanical properties. At the same time, an important function of the solvent system is to provide a controlled distribution of the polymer on the core surface to create a homogeneous coating.
Pharmaceutical Glossary
Technical specifications
Studies have shown that when the HPMC content in the blend is less than 24%, the release profile depends on the rate of water penetration into the coating, which in turn becomes a determining factor in selecting the ratio of polymer concentrations in the blend.
Most of the polymers used are available in a wide range of molecular weights, which is a major factor in the choice of coating technology. Molecular weight can have a significant effect on coating properties such as viscosity, mechanical strength, and film elasticity.
Plasticizers. A plasticizer is a liquid or solid with a high boiling point. Examples of plasticizers include glycerin, propylene glycol, polyethylene glycol, triacetin, esters of citric acid (e.g., triethyl citrate), esters of phthalic acid (e.g., triethyl phthalate). The introduction of a plasticizer can improve the elasticity of the coating Cracking the risk of mechanical damage and potentially in the coating improve the adhesion of the film coating to the core.
When the plasticizer interacts with the polymer, the minimum film formation temperature may be reduced. To form a quality film, the plasticizer must have high compatibility with the polymer and be permanently retained in the coating, especially if the main objective of the coating is the stability of the dosage form during storage.
Additional information
The scientific literature provides numerous examples of the effect of plasticizer concentration on the physicochemical properties of the film coating and on the release of the drug substance from the coated products. For example, high plasticizer content can reduce the release of metoprolol from Eudragit RS coated microspheres and improve the release stability of theophylline from coated microspheres during storage.
Moreover, the release rate of the drug substance has been shown to be influenced by the type of plasticizer. For example, the release of propanolol from microspheres coated with a mixture of ethylcellulose and Eudragit L100-55 is faster when using the hydrophilic plasticizer triethyl citrate than when using the hydrophobic dibutyl sebacinate. Other studies have shown that the plasticizer can leach out of the coating during dissolution, thus affecting both mechanical properties and the release of LVs.
Adhesion of coating substances during film application causes the formation of undesirable aggregates, and the resulting coatings may be damaged when attempts are made to separate adhering parts. This effect can be neutralized by adding anti-adhesion agents to the coating composition or by applying these agents immediately after the spray chamber. Useful anti-adhesion agents include talc, magnesium stearate, kaolin, etc.
Dyes. Dyes are commonly used to improve the appearance of the dosage form.
Order status tracking
Good afternoon, please confirm that tomorrow until 16:30 we will receive our shipment in Paris? Contact the transportation company. 25/04/2025 21:17
Hello Elijah ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Paris in a few days. Please expect it. 25/04/2025 21:17
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 25/04/2025 21:27
Liam, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer as agreed. We will report back immediately. 25/04/2025 21:31
Waiting for delivery to Sarajevo of a TR-02 hard gelatin capsule polishing machine. What about it? 25/04/2025 21:37
Hello James, on your order we inform you that in the morning the driver will contact you to clarify the time and place of unloading. 25/04/2025 21:38
YR-90 dry and wet powder granulator YR-90 month has already passed. Hurry up the factory. 25/04/2025 21:47
Penelope, good afternoon. The factory has shipped your equipment to our representative, now is forming a consolidated shipment for shipment to customs. We will keep you informed. 25/04/2025 21:47
Hello, is it possible to buy your blistering machine for tablets and capsules MN-80 1 piece with delivery to Long Beach ( Europe) ? How much time for delivery ? 25/04/2025 21:57
Jayden, hello! We have many customers from your city. Delivery to this region is made by EMC. 25/04/2025 21:59
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to Las Vegas. Thank you. 25/04/2025 22:07
Emily, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to Las Vegas is scheduled for tomorrow by lunchtime. Please notify us upon receipt. 25/04/2025 22:08
Roman, our company bought VL-100 V-shaped powder mixer, but it is not enough for us, can we return it and exchange it for V-300 model? 25/04/2025 22:17
Lily, good afternoon. When we corresponded with you, I warned you that this is a model with a small load. Unfortunately we can not pick up the equipment. As an option, we will offer our customers with a discount. 25/04/2025 22:19
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 25/04/2025 22:27
Hello Hazel, Our manager Natalia as agreed will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Rovinj in 15 days. 25/04/2025 22:29
Good afternoon, I am hoping as stipulated in the contract to get the UNIC 600A Tablet Press in Lucca ! Please comment. 25/04/2025 22:37
Good day, Aubrey! Our manager has communicated with the delivery service, the equipment will be delivered to Lucca at your address. Please let us know when you receive it. 25/04/2025 22:40
I would like to discuss the purchase of model FK-05 - capping and screw cap machine. 25/04/2025 22:47
Good day. You can call on tel. +79853643808 or to the mail specified on the site. Aubrey, this chat is only for tracking shipments. 25/04/2025 22:50
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- BOTTLE FILLING AND CAPPING EQUIPMENT
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER