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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / FILM-COATING OF TABLETS / Problems encountered during coating application

Problems encountered during coating application

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / FILM-COATING OF TABLETS / Problems encountered during coating application

Problems encountered during coating application

As with sugar coatings, problems can occur after or during the film coating process. Tablets, Pellets and Pellets to which the coating is applied may not be strong enough or may delaminate during the coating process. Due to the fact that film coatings are relatively thin, their ability to hide defects is significantly lower than that of sugar coatings. Various problems can arise when using film coating. One example is sticking, which occurs when the liquid feed rate exceeds the drying rate, causing tablets, pellets and granules to stick together and further break down.

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  • Information updated : 09 / 12 / 2024
  • In stock
  • Manufacturer : 1 year for Problems encountered during coating application

Model: Coating of tablets and capsules

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Knowledge of the physicochemical properties of the various excipients used in film-coated dosage forms and how they interact with each other, as well as knowledge of the parameters of the coating process (temperature, feed air velocity, etc.) allows the technologist to avoid the occurrence of most defects associated with internal stress.

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Technical specifications

Another example is the formation of an uneven or rough film, which is the result of premature drying of atomized liquid droplets or the result of spraying a coating solution that is too viscous. Uneven coloring or inhomogeneity of the coating color may result from poor distribution of the coloring agent in the coating. This defect is usually encountered either when soluble colorants are used in aqueous coatings (where migration of the colorant is possible), or when the solvent remaining in the film changes and the plasticizer migrates (if the colorant is soluble).

Additional information

The use of pigments in the coating process significantly reduces the formation of this defect. However, uneven coloration may result from insufficient pigment distribution in the coating solution. In conclusion, some defects may result from internal stresses that increase in the film as it dries. One example of such defects may be the formation of cracks that occur when the stresses exceed the tensile strength of the film.

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