Video review of the model
Our service and customer service
One of the most important factors is the intended use of the product, which determines the conditions under which the encapsulated substance is used and its properties are manifested. This determines the choice of film-forming material and the resulting choice of microencapsulation medium. Slow release of the substance by diffusion requires the use of a film-forming material that swells rather than dissolves in the medium in which the microcapsules are used. On the other hand, rapid release can be achieved by selecting a film-forming material that is soluble, meltable or brittle. A further factor is the stability and solubility of the encapsulated substance under microencapsulation conditions. The instability of many substances even at a slight increase in temperature (enzymes, some vitamins, volatile liquids) limits the possibility of using methods involving heating. Methods based on the separation of liquid phases (methods of formation of a new phase from solutions) can be an alternative in this case. In this case, the properties of the substance will determine the choice of dispersion medium and dispersed phase. Of great importance is the cost of the process, so preference is given to methods involving a smaller number of stages and carried out in a continuous mode. The required size of the microcapsules, the content of the encapsulated substance and the efficiency of microencapsulation are also important factors. The above classification of microencapsulation methods, which is based on the nature of the processes occurring during microencapsulation, is rather conventional. In practice, a combination of different methods is often used. Below we will consider the most frequently used in the chemical-pharmaceutical industry methods of microencapsulation.
Pharmaceutical Glossary
Technical specifications
The main component of microcapsules – the substance to be encapsulated – can be in any aggregate state – liquid, solid, gaseous. The existing methods provide the possibility of microencapsulation of both lyophilic and lyophobic substances. The contents of microcapsules may include an inert filler, which is the medium in which the substance was dispersed in the process of microencapsulation, or is necessary for the subsequent functioning of the active substance. The content of the encapsulated substance in the microcapsules is typically 50-95% of the weight of the capsules. This value may vary depending on the technology and conditions of production, the required ratio of shell material and encapsulated substance, as well as on other process parameters: temperature, degree of dispersion, viscosity of the medium, presence of surfactants, etc. The term “microcapsules” or “nanocapsules” can refer to many different structures. One can use molecules within which the active ingredient is trapped, as well as complexes of complex molecules from which nanocapsules or nanospheres are formed. Nanoencapsulation is said to occur when the size of the molecules is less than a few micrometers. When the size of the molecules is less than one millimeter, we speak of microencapsulation. Different classes of substances can be used as shell material or encapsulating matrix: Waxes and lipids: beeswax, candelilla and carnuba waxes, wax emulsions, glycerol distearate, natural and modified fats. Proteins: gelatin, wheat proteins, soy proteins, zein, gluten, etc. Both proteins themselves and their modifications are used. Carbohydrates: starches, maltodextrins, chitosan, sucrose, glucose, ethyl cellulose, acetate cellulose, alginates, etc.
Additional information
Degradable polymers: polypropylene, polyvinyl acetate, polystyrene, polybutadiene, etc. The choice of material of shells or encapsulating matrix depends on the purpose, properties and method of release of the encapsulating agent, as well as on the chosen method of microencapsulation. The contents of microcapsules can be released by mechanical destruction of the shells under pressure, by friction, ultrasonic action, melting, by rupture from the inside by vapors or gaseous substances released under changing external conditions, by interaction of the shell substance with the medium when dissolved in it, as well as by diffusion of the contents when the capsule walls swell in the surrounding liquid. Existing methods of microencapsulation can be divided into three main groups: Physical methods of microencapsulation are based on methods of forming shells by mechanical techniques. This group of methods includes fluidized bed coating, extrusion using centrifuges or through tube-in-tube forming devices, vapor condensation (vacuum spraying). Chemical methods are based on chemical transformations leading to film-forming material, namely – formation of a new phase by cross-linking of polymers, poly condensation and polymerization. Both high molecular weight substances (oligomers or polymers) and low molecular weight substances can be subjected to chemical transformations. Physicochemical methods include coacervation, precipitation of film-forming polymer from aqueous medium by adding a component that reduces its solubility, formation of a new phase by temperature change, evaporation of a volatile solvent, solidification of melts in liquid media, extraction substitution, spray drying, and physical adsorption. When selecting a microencapsulation method, several major factors must be considered.
Order status tracking
Contract #12, the deadline for delivery has already passed. Take action at last. Accelerate Tsibulsky R.G. 15/07/2025 02:44
Hello Ella, we are on vacation on weekends and are not able to respond to messages. Raise the contract, delivery time of equipment to your warehouse in Vienna to 50 working ( not calendar) days. Action taken. 15/07/2025 02:45
Hello, is it possible to buy your blistering machine for tablets and capsules MN-80 1 piece with delivery to Atlanta ( Europe) ? How much time for delivery ? 15/07/2025 02:54
Penelope, hello! We have many customers from your city. Delivery to this region is made by EMC. 15/07/2025 02:56
We have sent to info@minipress.ru photos of the damaged box with induction welding membrane machine FG-08. Please call back. 15/07/2025 03:04
Good day, Nova! Damage to the packaging is unfortunately a common practice in transportation. Please carefully unpack the shipment and send us a series of photos. We will take a look and take action. 15/07/2025 03:07
Roman, can you tell me if my rotary tablet press RZJ-35 has been shipped yet? Don't send it yet, I will send to your factory in China drawings of new punches, different design. 15/07/2025 03:14
Good afternoon, Dylan! We're pausing the shipment. Send drawings to the office mail. The terms of production of new punches 20 working days. 15/07/2025 03:16
Roman, can you tell me if my rotary tablet press RZJ-35 has been shipped yet? Don't send it yet, I will send to your factory in China drawings of new punches, different design. 15/07/2025 03:24
Good afternoon, Ellie! We're pausing the shipment. Send drawings to the office mail. The terms of production of new punches 20 working days. 15/07/2025 03:27
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Vienna, then I want to buy an automatic capsule machine model GN-28 15/07/2025 03:34
Good afternoon, Alexander! On the first question - the shipment will arrive in Vienna tomorrow until 18: 30. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 15/07/2025 03:38
Natalia tell me, automatic double-sided labeling machine ST-36 has left the factory, invoice #118. 15/07/2025 03:44
Hello Jackson, The equipment has been shipped from the transit warehouse and delivery is proceeding as planned. No delays are expected. 15/07/2025 03:46
Hello, is it possible to buy your blistering machine for tablets and capsules MN-80 1 piece with delivery to New York ( Europe) ? How much time for delivery ? 15/07/2025 03:54
Aria, hello! We have many customers from your city. Delivery to this region is made by EMC. 15/07/2025 03:57
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in Pittsburgh 15/07/2025 04:04
Hello Aurora, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 15/07/2025 04:07
PU-420 flow-pack packaging machine along with 500 kg packaging , delivery to Kansas City. Please confirm the delivery time. 15/07/2025 04:14
Good afternoon Aria, your shipment has left. Arrival time tomorrow until 15:30. The driver will call you back later. Please organize prompt unloading. 15/07/2025 04:16
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR COATING TABLETS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION