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One of the most important factors is the intended use of the product, which determines the conditions under which the encapsulated substance is used and its properties are manifested. This determines the choice of film-forming material and the resulting choice of microencapsulation medium. Slow release of the substance by diffusion requires the use of a film-forming material that swells rather than dissolves in the medium in which the microcapsules are used. On the other hand, rapid release can be achieved by selecting a film-forming material that is soluble, meltable or brittle. A further factor is the stability and solubility of the encapsulated substance under microencapsulation conditions. The instability of many substances even at a slight increase in temperature (enzymes, some vitamins, volatile liquids) limits the possibility of using methods involving heating. Methods based on the separation of liquid phases (methods of formation of a new phase from solutions) can be an alternative in this case. In this case, the properties of the substance will determine the choice of dispersion medium and dispersed phase. Of great importance is the cost of the process, so preference is given to methods involving a smaller number of stages and carried out in a continuous mode. The required size of the microcapsules, the content of the encapsulated substance and the efficiency of microencapsulation are also important factors. The above classification of microencapsulation methods, which is based on the nature of the processes occurring during microencapsulation, is rather conventional. In practice, a combination of different methods is often used. Below we will consider the most frequently used in the chemical-pharmaceutical industry methods of microencapsulation.
Pharmaceutical Glossary
Technical specifications
The main component of microcapsules – the substance to be encapsulated – can be in any aggregate state – liquid, solid, gaseous. The existing methods provide the possibility of microencapsulation of both lyophilic and lyophobic substances. The contents of microcapsules may include an inert filler, which is the medium in which the substance was dispersed in the process of microencapsulation, or is necessary for the subsequent functioning of the active substance. The content of the encapsulated substance in the microcapsules is typically 50-95% of the weight of the capsules. This value may vary depending on the technology and conditions of production, the required ratio of shell material and encapsulated substance, as well as on other process parameters: temperature, degree of dispersion, viscosity of the medium, presence of surfactants, etc. The term “microcapsules” or “nanocapsules” can refer to many different structures. One can use molecules within which the active ingredient is trapped, as well as complexes of complex molecules from which nanocapsules or nanospheres are formed. Nanoencapsulation is said to occur when the size of the molecules is less than a few micrometers. When the size of the molecules is less than one millimeter, we speak of microencapsulation. Different classes of substances can be used as shell material or encapsulating matrix: Waxes and lipids: beeswax, candelilla and carnuba waxes, wax emulsions, glycerol distearate, natural and modified fats. Proteins: gelatin, wheat proteins, soy proteins, zein, gluten, etc. Both proteins themselves and their modifications are used. Carbohydrates: starches, maltodextrins, chitosan, sucrose, glucose, ethyl cellulose, acetate cellulose, alginates, etc.
Additional information
Degradable polymers: polypropylene, polyvinyl acetate, polystyrene, polybutadiene, etc. The choice of material of shells or encapsulating matrix depends on the purpose, properties and method of release of the encapsulating agent, as well as on the chosen method of microencapsulation. The contents of microcapsules can be released by mechanical destruction of the shells under pressure, by friction, ultrasonic action, melting, by rupture from the inside by vapors or gaseous substances released under changing external conditions, by interaction of the shell substance with the medium when dissolved in it, as well as by diffusion of the contents when the capsule walls swell in the surrounding liquid. Existing methods of microencapsulation can be divided into three main groups: Physical methods of microencapsulation are based on methods of forming shells by mechanical techniques. This group of methods includes fluidized bed coating, extrusion using centrifuges or through tube-in-tube forming devices, vapor condensation (vacuum spraying). Chemical methods are based on chemical transformations leading to film-forming material, namely – formation of a new phase by cross-linking of polymers, poly condensation and polymerization. Both high molecular weight substances (oligomers or polymers) and low molecular weight substances can be subjected to chemical transformations. Physicochemical methods include coacervation, precipitation of film-forming polymer from aqueous medium by adding a component that reduces its solubility, formation of a new phase by temperature change, evaporation of a volatile solvent, solidification of melts in liquid media, extraction substitution, spray drying, and physical adsorption. When selecting a microencapsulation method, several major factors must be considered.
Order status tracking
I would like to discuss the purchase of model FK-05 - capping and screw cap machine. 10/04/2025 23:02
Good day. You can call on tel. +79853643808 or to the mail specified on the site. Nova, this chat is only for tracking shipments. 10/04/2025 23:05
Natalia tell me, automatic double-sided labeling machine ST-36 has left the factory, invoice #118. 10/04/2025 23:12
Hello Michael, The equipment has been shipped from the transit warehouse and delivery is proceeding as planned. No delays are expected. 10/04/2025 23:16
YR-90 dry and wet powder granulator YR-90 month has already passed. Hurry up the factory. 10/04/2025 23:22
Noah, good afternoon. The factory has shipped your equipment to our representative, now is forming a consolidated shipment for shipment to customs. We will keep you informed. 10/04/2025 23:25
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Crete ? 10/04/2025 23:32
Hello Ethan, your shipment is in the customs warehouse, as agreed your manager Natalia will contact you. 10/04/2025 23:32
We received our order (BG-150 film coating boiler) in the box there was no spraying nozzle !!! 10/04/2025 23:42
Hello Daniel, we checked with the factory. Your nozzle was not received in time for the shipment of the main machine. We will now deliver it to you by DHL express mail. 10/04/2025 23:44
The MZ-10 expiration date and date handheld printer has still not been delivered. The driver did not answer and dropped calls yesterday. 10/04/2025 23:52
Hello Savannah, Transportation has advised that between 16:00-18:00 driver will definitely deliver the box to your address. We apologize. 10/04/2025 23:53
Good day, tell me need delivery in Tempe to the settlement in the distance of 20 km. Can you organize this? 11/04/2025 00:02
Leo, Good afternoon, please send us an email to info@minipress.ru with the exact name of the equipment model, city, and your coordinates. We will calculate the delivery to you. 11/04/2025 00:03
Dear Roman. Deadline (time) I am waiting for your quotation for a machine for removing tablets and capsules from blister packs MB-10 with delivery. 11/04/2025 00:12
Hello Sebastian, By the specified time we will send the offer to your e-mail. Now we are waiting for an answer from the transportation company on the delivery time to Orora . 11/04/2025 00:14
The MZ-10 expiration date and date handheld printer has still not been delivered. The driver did not answer and dropped calls yesterday. 11/04/2025 00:22
Hello Sofia, Transportation has advised that closer to evening driver will definitely deliver the box to your address. We apologize. 11/04/2025 00:24
Roman, our company bought VL-100 V-shaped powder mixer, but it is not enough for us, can we return it and exchange it for V-300 model? 11/04/2025 00:32
Chloe, good afternoon. When we corresponded with you, I warned you that this is a model with a small load. Unfortunately we can not pick up the equipment. As an option, we will offer our customers with a discount. 11/04/2025 00:33
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COATING TABLETS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC CARTONING MACHINES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COATING TABLETS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION