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The filtration system ensures that fine particles are fully returned to the process and no product separation into fractions occurs. This design allows efficient coating of pellets, microparticles, tablets of different shapes, sizes and densities and allows the granulation process to be carried out in large production batches. Tangential coating is optimally suited for the creation of shells with a high solids content and is carried out on the machine. It is driven in a spiral direction by a rotating gas distribution grate, from the edges of which the supplied air is directed into the product layer. A spray nozzle is arranged tangentially with respect to the rotor insert and atomizes the liquid into the product layer in the same direction. Using the rotor method, a very thick film layer can be applied. This method is also suitable for producing pellets by direct pelletizing in a fluidized bed. Coating by jet fluidization technology is used for tablets and pellets that are difficult to fluidize. Fluidizing jet technology makes it possible to coat extremely fine, coarse and polydisperse products. In contrast to conventional fluidized bed processes, the air enters the working chamber through a longitudinal slit instead of a gas distribution grate. As a result of the two-stage expansion of the bed (in the working chamber and above the working chamber), the process air velocity drops drastically. As a consequence, no fine particles are transported out of the process, which makes it possible to fluidize even finely dispersed products. It is also possible to fluidize coarse and polydisperse products, as the flow velocity in the center of the fluidization chamber is high. A stable fluidized bed is also possible with sticky and lumpy products. The speed of the product can be adjusted as it is transported in a directional manner: upwards in the middle and downwards on the sides. The central nozzles spray at the place of the highest product speed and the highest energy flow. Due to the high product velocity at the nozzle there is no agglomeration of particles. High atomization performance is also possible with small amounts of product in the spraying chamber. At the same output, the average processing time with this technology is reduced compared to conventional fluidized bed technology. Coating is an important process step in the manufacture of solid dosage forms. The challenge for many pharmaceutical companies is to develop and search for new properties of coating agents and to apply innovative coating technologies and equipment.
Pharmaceutical Glossary
Technical specifications
In fluidized bed coating, the pellets and pellets are “liquefied”, the coating fluid is sprayed on them and the product is dried. The small droplet size and low viscosity of the atomizing medium ensure uniform application of the product.
Overhead spray coating is used for a wide range of coatings, from general purpose coatings to gastric juice soluble coatings. In overhead spray coating in fluidized bed (in batch and continuous systems), the particles are “liquefied” in a stream of heated air, which flows through a gas distribution grid into the product container. The coating fluid is injected into the fluidized bed through a nozzle in the opposite direction to the air flow (countercurrent, from top to bottom). With further upward movement of the particles in the air flow, drying takes place. To carry out the coating process, two types of fluidized bed systems are used: batch and continuous. These plants can also be used for the granulation process (see section 4.8). %. Glatt batch fluidized bed plant. The conical shape of the zone where the gas flow velocity is reduced allows even very fine products to be processed. Different variants of the gas distribution grids ensure an optimum gas flow over the product.
Glatt continuous fluidized bed coater. The coating method is particularly suitable for the creation of protective and colored coatings under the condition of high process throughput.
The product is continuously fed from one side of the plant and transported upwards by the air flow over the gas distribution grid. The plant is divided into different zones for different purposes: preheating, spraying and drying. The dry coated tablets are continuously removed from the plant.
Spray coating from below in a batch fluidized bed plant using the HS Wurster Glatt nozzle is particularly suitable for the production of pellets and pellets with controlled release of bioactive substances. When conducting the coating process with the HS Wurster nozzle, complete coverage of the particle surface can be achieved with a small amount of coating agent. The atomizing nozzle is installed in the gas distribution grille so that the atomizing agent moves in the same direction as the air flow. By using the Wurster HS nozzle and a gas distribution grid with different types of perforations, the coated particles are accelerated inside the nozzle and flow uniformly through the atomizing cone.
Additional information
In a further upward motion, the particles dry out and descend again outside the HS Wurster nozzle to the gas distribution grid. There they are again directed towards the inside of the nozzle, where they are again accelerated by the atomizing liquid jet, thus forming very homogeneous films. As a result, particles of different sizes have a uniform film coating. Spray coating from below in a continuous fluidized bed system developed by Glatt is particularly suitable for the creation of protective and colored coatings under the condition of a high production rate. The product is continuously fed from one side of the plant and transported by the air flow upwards above the gas distribution grid. The plant is divided into different zones: preheating zone, atomization zone and drying zone, with atomization from below. Dry pellets and coated pellets are continuously removed from the plant. Spray coating from below in a fluidized bed system developed by Hiittlin. Thanks to Hiittlin’s Turbojet and Diskjet gas distribution units, the product flows in a defined direction throughout the entire container volume as well as in the spray area. Due to the defined geometry of the units, the air flow can be precisely controlled. Homogeneous product movement and mixing is achieved. Due to the 45° angle of air flow, the strain on the filters is reduced. There are no stagnant zones in the product container.
In fluidized bed apparatuses for coating, the nozzles that atomize the coating agents are of great importance. The nozzle has a third component called microclimate, which is what distinguishes it from the one used in conventional technology. The microclimate keeps the nozzle clean of solution and product. Thus, the distribution and droplet size remain constant and are reproducible. The nozzle is freely accessible during operation, so there is no need to interrupt the process in case of nozzle clogging. Solution losses are reduced due to the appropriate nozzle positioning. INN O JET has developed the AirCoater coating machine, which allows the coating to be applied with a high degree of efficiency. The special feature of this unit is the INNOJET Orbiter gas distribution unit of a somewhat unusual design. The flow of process air passes through the holes of the gas distribution unit, which is a ring of different diameters, assembled in a single structure with gaps between them. This assembly design ensures efficient, gentle and reproducible product flow. Application of the atomized liquid is carried out by a spray nozzle, which can be used to control the droplet size. Atomization takes place at 360°, which allows an even application of the coatings.
Order status tracking
LW-35 automatic PVC+cardboard blister packaging machine has been on the road for 30 days. What news ? 21/11/2024 09:50
Hello Ellie, We are on time, as stipulated in the contract a driver will contact you about unloading. 21/11/2024 09:52
Roman, can you tell me if my rotary tablet press RZJ-35 has been shipped yet? Don't send it yet, I will send to your factory in China drawings of new punches, different design. 21/11/2024 10:00
Good afternoon, Grace! We're pausing the shipment. Send drawings to the office mail. The terms of production of new punches 20 working days. 21/11/2024 10:02
RZW-29 rotary tablet press in Monte Carlo. Regards, John. 21/11/2024 10:10
John, Delivery will be made tomorrow until 16:30 to Monte Carlo . Please have the movers ready. The weight of the equipment is heavy. 21/11/2024 10:10
Good afternoon! semi-automatic liquid filling machine in barrels DF-13 , a copy of the payment is sent to the post. Start the order to work. 21/11/2024 10:20
Amelia, good afternoon! We have seen your payment, we receive SMS from the bank. Please send drawings of barrels and answers to our questions in correspondence. 21/11/2024 10:22
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Strasbourg ? 21/11/2024 10:30
Hello Emma, Expect closer to evening. Once received, please let us know. 21/11/2024 10:30
Natalia tell me, automatic double-sided labeling machine ST-36 has left the factory, invoice #118. 21/11/2024 10:40
Hello James, The equipment has been shipped from the transit warehouse and delivery is proceeding as planned. No delays are expected. 21/11/2024 10:42
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 21/11/2024 10:50
Hello Emilia, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 21/11/2024 10:54
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled between 12:00-14:00 to open the box and test. 21/11/2024 11:00
Samuel, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 21/11/2024 11:01
Good afternoon, I am hoping after lunch to get the UNIC 600A Tablet Press in Rovinj ! Please comment. 21/11/2024 11:10
Good day, Brooklyn! Our manager has communicated with the delivery service, the equipment will be delivered to Rovinj at your address. Please let us know when you receive it. 21/11/2024 11:12
Natalia tell me, automatic double-sided labeling machine ST-36 has left the factory, invoice #118. 21/11/2024 11:20
Hello Savannah, The equipment has been shipped from the transit warehouse and delivery is proceeding as planned. No delays are expected. 21/11/2024 11:24
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR COATING TABLETS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING