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The specificity of the freeze drying process determines its main advantages: moisture is removed at low temperatures, which practically eliminates thermal inactivation of the product practically eliminates the removal of volatile components of the dried material, violation of its chemical composition; facilitates the possibility of obtaining a dry product in packaged sterile form (ampoules, vials). The main disadvantages of freeze drying include: periodicity, duration and energy intensity of the process, complexity of equipment and high hygroscopicity of the dried material. The main reason for the high cost of the freeze drying process is that the process, which takes place at negative temperatures, is not as intensive as at positive temperatures, the driving force of the process is lower than in the case of thermal drying methods. There are a number of ways to intensify the process and, consequently, to reduce the drying time: carrying out the process under vacuum under conditions of active hydrodynamics, combining with radiation drying and others.
Pharmaceutical Glossary
Technical specifications
The main advantage and distinctive feature of freeze dehydration is that the process takes place at subzero temperatures. The dried product is pre-frozen, and moisture removal occurs due to sublimation – phase transition from solid to vapor state, bypassing the liquid state. The ice-vapor phase transition can be realized under certain conditions in accordance with the phase diagram for water. The partial pressure of water vapor and the temperature of the material must be below the corresponding values for the triple point. Due to the low-temperature conditions of freeze dehydration, the original properties of the product are not only preserved (volatile? biologically active substances, original odor, taste, color), but also improved due to the concentration of the most valuable components.
Additional information
Freeze drying proceeds in three main stages: pre-freezing of the product; removal of all frozen moisture from the product by sublimation (period of constant drying rate); removal of part of the unfrozen (bound) moisture with increasing temperature to an acceptable level (period of falling drying rate). In freeze drying of pharmaceuticals, the freeze drying stage is the key stage in the formation of internal structure and morphology of particles, solubility and stability of the dry product. In addition, loss of biological activity of pharmaceutical substances is possible at this stage. The process of freeze drying of products of microbiological, food, medical and other industries takes place mainly in conditions of medium discharge at temperatures from -5 to -35 °С. The lyophilic drying unit consists of a drying chamber, a desublimator condenser and a vacuum pumping system.
Order status tracking
LW-35 automatic PVC+cardboard blister packaging machine has been on the road for 30 days. What news ? 28/10/2024 21:47
Hello Nora, We are on time, tomorrow until 13:30 a driver will contact you about unloading. 28/10/2024 21:51
Dear Roman, good afternoon, vacuum powder conveyors QV-05 in quantity of 4 pieces, already on their way to Sigisoara ? 28/10/2024 21:57
Good afternoon, Daniel! Our manager has sent a scan of the bill of lading to your email. The shipment is on its way. 28/10/2024 22:01
Hello Roman! Thank you for the service and quality of your products. We are very happy and satisfied with the purchase! 28/10/2024 22:07
Hello Emily, Apparently you have tested your vacuum lyophilic dryer LZY-01. Its quality is above average, it will work. We are waiting for your new applications. 28/10/2024 22:10
In Geneva ITA-01 tablet and capsule counter, RZ-9 rotary tablet press and manual capsule filling machine. Help when we get it ? 28/10/2024 22:17
Good afternoon, Aiden! We have received from the factories photos of the equipment after packing. Natalia will forward the photos to you. Delivery time to you is 45-50 days. 28/10/2024 22:18
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Helsinki ? 28/10/2024 22:27
Hello Sebastian, Expect before lunch. Once received, please let us know. 28/10/2024 22:30
Mixer with paddle for powders CX-100 what is the exact packing size ? 28/10/2024 22:37
Isabella, Hello! Packing dimensions 1200x640x1000 mm, packing weight 250 kg. Please let me know when you receive the shipment. 28/10/2024 22:40
We're from New Jersey, we paid for the equipment on your invoice yesterday. Has the payment been received? How long will it take to deliver to us? 28/10/2024 22:47
Lucas, hello. Payment is credited to our settlement account. Term of manufacture of your equipment by the factory 20 working days, delivery from the factory to our warehouse in the USA 1 month, delivery from the warehouse in Washington 15 calendar days. 28/10/2024 22:51
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 28/10/2024 22:57
Hello Samuel, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 28/10/2024 22:59
Can your technician come to Tbilisi? We need technologist consultation and assistance. 28/10/2024 23:07
Benjamin, We have already received your email. A technician tomorrow until 16:30 will contact you. Don't worry. 28/10/2024 23:10
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 28/10/2024 23:17
Aurora, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer tomorrow until 16:30. We will report back immediately. 28/10/2024 23:20
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR COATING TABLETS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS