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The specificity of the freeze drying process determines its main advantages: moisture is removed at low temperatures, which practically eliminates thermal inactivation of the product practically eliminates the removal of volatile components of the dried material, violation of its chemical composition; facilitates the possibility of obtaining a dry product in packaged sterile form (ampoules, vials). The main disadvantages of freeze drying include: periodicity, duration and energy intensity of the process, complexity of equipment and high hygroscopicity of the dried material. The main reason for the high cost of the freeze drying process is that the process, which takes place at negative temperatures, is not as intensive as at positive temperatures, the driving force of the process is lower than in the case of thermal drying methods. There are a number of ways to intensify the process and, consequently, to reduce the drying time: carrying out the process under vacuum under conditions of active hydrodynamics, combining with radiation drying and others.
Pharmaceutical Glossary
Technical specifications
The main advantage and distinctive feature of freeze dehydration is that the process takes place at subzero temperatures. The dried product is pre-frozen, and moisture removal occurs due to sublimation – phase transition from solid to vapor state, bypassing the liquid state. The ice-vapor phase transition can be realized under certain conditions in accordance with the phase diagram for water. The partial pressure of water vapor and the temperature of the material must be below the corresponding values for the triple point. Due to the low-temperature conditions of freeze dehydration, the original properties of the product are not only preserved (volatile? biologically active substances, original odor, taste, color), but also improved due to the concentration of the most valuable components.
Additional information
Freeze drying proceeds in three main stages: pre-freezing of the product; removal of all frozen moisture from the product by sublimation (period of constant drying rate); removal of part of the unfrozen (bound) moisture with increasing temperature to an acceptable level (period of falling drying rate). In freeze drying of pharmaceuticals, the freeze drying stage is the key stage in the formation of internal structure and morphology of particles, solubility and stability of the dry product. In addition, loss of biological activity of pharmaceutical substances is possible at this stage. The process of freeze drying of products of microbiological, food, medical and other industries takes place mainly in conditions of medium discharge at temperatures from -5 to -35 °С. The lyophilic drying unit consists of a drying chamber, a desublimator condenser and a vacuum pumping system.
Order status tracking
We received our order (BG-150 film coating boiler) in the box there was no spraying nozzle !!! 17/05/2025 15:28
Hello Ava, we checked with the factory. Your nozzle was not received in time for the shipment of the main machine. We will now deliver it to you by DHL express mail. 17/05/2025 15:28
PU-250 flow-pack packaging machine, please advise delivery status. 17/05/2025 15:38
Hello Owen, your equipment is undergoing customs clearance. Your manager Natalia will contact you before lunch 17/05/2025 15:39
Dear Roman. Deadline (time) I am waiting for your quotation for a machine for removing tablets and capsules from blister packs MB-10 with delivery. 17/05/2025 15:48
Hello Daniel, By the specified time we will send the offer to your e-mail. Now we are waiting for an answer from the transportation company on the delivery time to Boston . 17/05/2025 15:49
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Porto, then I want to buy an automatic capsule machine model GN-28 17/05/2025 15:58
Good afternoon, Carter! On the first question - the shipment will arrive in Porto tomorrow until 14:30. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 17/05/2025 16:00
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Lisbon, do you deliver to the terminal or to the actual address? 17/05/2025 16:08
Hello Aiden, we deliver all over USA including to Lisbon . The price in the catalog includes any delivery our customer asks for. 17/05/2025 16:09
To what address to send you samples of bottles and caps to send them to the factory ? Regards Lily. 17/05/2025 16:18
Good day, Lily We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 17/05/2025 16:20
Good day, delivery time of semi-automatic drum filling machine DF-10 to Mariehamn, will the courier call us? 17/05/2025 16:28
Owen, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 17/05/2025 16:32
Good afternoon, please confirm that tomorrow until 12:30 we will receive our shipment in Bratislava? Contact the transportation company. 17/05/2025 16:38
Hello Amelia ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Bratislava in a few days. Please expect it. 17/05/2025 16:40
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 17/05/2025 16:48
Isabella, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Miami ? Contact Natalia, she will send the contract and invoice. 17/05/2025 16:50
How to contact you for shipment tracking ? Industrial vibrating screen VS-04. 17/05/2025 16:58
Good afternoon, Joseph, My WhastApp is +79853643808, Manager Natalia +79153808881 during business hours and except weekends. 17/05/2025 17:02
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR COATING TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER