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The specificity of the freeze drying process determines its main advantages: moisture is removed at low temperatures, which practically eliminates thermal inactivation of the product practically eliminates the removal of volatile components of the dried material, violation of its chemical composition; facilitates the possibility of obtaining a dry product in packaged sterile form (ampoules, vials). The main disadvantages of freeze drying include: periodicity, duration and energy intensity of the process, complexity of equipment and high hygroscopicity of the dried material. The main reason for the high cost of the freeze drying process is that the process, which takes place at negative temperatures, is not as intensive as at positive temperatures, the driving force of the process is lower than in the case of thermal drying methods. There are a number of ways to intensify the process and, consequently, to reduce the drying time: carrying out the process under vacuum under conditions of active hydrodynamics, combining with radiation drying and others.
Pharmaceutical Glossary
Technical specifications
The main advantage and distinctive feature of freeze dehydration is that the process takes place at subzero temperatures. The dried product is pre-frozen, and moisture removal occurs due to sublimation – phase transition from solid to vapor state, bypassing the liquid state. The ice-vapor phase transition can be realized under certain conditions in accordance with the phase diagram for water. The partial pressure of water vapor and the temperature of the material must be below the corresponding values for the triple point. Due to the low-temperature conditions of freeze dehydration, the original properties of the product are not only preserved (volatile? biologically active substances, original odor, taste, color), but also improved due to the concentration of the most valuable components.
Additional information
Freeze drying proceeds in three main stages: pre-freezing of the product; removal of all frozen moisture from the product by sublimation (period of constant drying rate); removal of part of the unfrozen (bound) moisture with increasing temperature to an acceptable level (period of falling drying rate). In freeze drying of pharmaceuticals, the freeze drying stage is the key stage in the formation of internal structure and morphology of particles, solubility and stability of the dry product. In addition, loss of biological activity of pharmaceutical substances is possible at this stage. The process of freeze drying of products of microbiological, food, medical and other industries takes place mainly in conditions of medium discharge at temperatures from -5 to -35 °С. The lyophilic drying unit consists of a drying chamber, a desublimator condenser and a vacuum pumping system.
Order status tracking
Today we were promised delivery of a blister machine for MN-14 tablets and capsules, remember us ? No one's called us back. 24/08/2024 14:01
Hello Liam, Our manager Natalya tomorrow until 16:30 will dial the driver, also we ask you yourself to the transportation company. 24/08/2024 14:04
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Luzern, do you deliver to the terminal or to the actual address? 24/08/2024 14:11
Hello Penelope, we deliver all over USA including to Luzern . The price in the catalog includes any delivery our customer asks for. 24/08/2024 14:15
Automatic blister packaging machine for PVC+cardboard LW-35 with delivery to Long Beach. We want to track the delivery status. 24/08/2024 14:21
Leah, hello. The shipment has already arrived. Now it is in the warehouse of the transportation company. Your manager will contact you to clarify the time of delivery to your city. 24/08/2024 14:24
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Krakow, do you deliver to the terminal or to the actual address? 24/08/2024 14:31
Hello Grace, we deliver all over USA including to Krakow . The price in the catalog includes any delivery our customer asks for. 24/08/2024 14:34
Please inform me about the status of the order Rotary tablet press RZ-10A in San Diego ? 24/08/2024 14:41
Good afternoon, Ava. We have contacted the carrier, delivery is scheduled as agreed. Please let us know when you receive it. Thank you. 24/08/2024 14:42
How to contact you for shipment tracking ? Industrial vibrating screen VS-04. 24/08/2024 14:51
Good afternoon, Lily, My WhastApp is +79853643808, Manager Natalia +79153808881 during business hours and except weekends. 24/08/2024 14:54
Automatic blister packaging machine for PVC+cardboard LW-35 with delivery to Colorado Springs. We want to track the delivery status. 24/08/2024 15:01
Evelyn, hello. The shipment has already arrived. Now it is in the warehouse of the transportation company. Your manager will contact you to clarify the time of delivery to your city. 24/08/2024 15:02
Remember me? There's a delivery in the Rotterdam 24/08/2024 15:11
Scarlett, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be tomorrow by lunchtime in Rotterdam . 24/08/2024 15:14
Dear Roman, good afternoon, vacuum powder conveyors QV-05 in quantity of 4 pieces, already on their way to Ljubljana ? 24/08/2024 15:21
Good afternoon, Jackson! Our manager has sent a scan of the bill of lading to your email. The shipment is on its way. 24/08/2024 15:23
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 24/08/2024 15:31
Good afternoon Ellie, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. before lunch we will get a reply from the manufacturer on the final time frame. 24/08/2024 15:35
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- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
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- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
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- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
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- EQUIPMENT FOR THE PRODUCTION OF TABLETS
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- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
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- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC CARTONING MACHINES
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- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES