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This process is usually used to increase the dissolution rate of the active ingredient and consequently increase the bioavailability of poorly soluble drug substances. Solidification is a process in which the drug is melted, dissolved or dispersed in hot resins, waxes or fatty acids and atomized in an air chamber where the temperature is maintained below the melting point of the formulation components to produce solidified microspheres. Depending on the physicochemical properties of the components, and the loading composition, this process can produce microspheres with conventional or modified release. Compression is one of the compaction technologies to produce microspheres. By compressing a mixture of active ingredients and excipients under pressure, microspheres of specific sizes and shapes can be obtained. The composition of the loading and the process conditions controlling the quality of the finished microspheres are similar to the parameters for the production of tablets.
Pharmaceutical Glossary
Technical specifications
A variety of layers with different characteristics can be applied. Pellets obtained by this technology have many positive characteristics such as spherical shape, good flowability, dosability, compact structure, low hygroscopicity, high bulk weight, dense and homogeneous surface layer, narrow particle size distribution, high resistance. External to abrasion, the ability to incorporate a large number of species of multilayer bioactive substances and optimal initial pellet shape for subsequent coating. With the rotor method, it is possible to apply the film in very thick layers. Pellets containing large amounts of bioactive substances (when necessary) can be produced with this technology. In layer-by-layer pelletizing, the biologically active substance can be: sprayed onto the initial nuclei as a solution with a concentration of up to 50%; sprayed as a suspension; dosed in powder form in combination with a solvent and binder feed.
Additional information
In this case, the mass gain during layer-by-layer pelletizing in the rotor can be up to 10-fold of the initial mass. The layering of drug on microspheres is also carried out in centrifugal granulators, which can be used to obtain multi-element products with conventional or modified drug release. Using such systems, the primary granules can be prepared, drug substance layered and coated in the same, equipment to produce spherical multilayer granules with the desired drug substance release. In addition to the methods described above, which are the most common, other methods of producing microspheres such as globulation, solidification and compression are used to a limited extent in the pharmaceutical industry. Globulation consists of two related processes: spray drying and solidification. Spray drying is a process in which a suspension or solution of a drug substance without excipients is atomized in a stream of hot air to produce dry spherical particles.
Order status tracking
Waiting for delivery to Lyme of a TR-02 hard gelatin capsule polishing machine. What about it? 19/05/2024 18:59
Hello Aiden, on your order we inform you that the day after tomorrow the driver will contact you to clarify the time and place of unloading. 19/05/2024 18:59
To what address to send you samples of bottles and caps to send them to the factory ? Regards Zoe. 19/05/2024 19:09
Good day, Zoe We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 19/05/2024 19:10
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Brussels ? 19/05/2024 19:19
Hello Hannah, your shipment is in the customs warehouse, in the morning your manager Natalia will contact you. 19/05/2024 19:19
Remember me? There's a delivery in the Bruges 19/05/2024 19:29
Grace, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be in the interval from 10:00-12:00 in Bruges . 19/05/2024 19:32
Rotary tablet press RZK-25 I want to order with delivery to Berlin 19/05/2024 19:39
Good day, Lily We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 19/05/2024 19:41
Today we were promised delivery of a blister machine for MN-14 tablets and capsules, remember us ? No one's called us back. 19/05/2024 19:49
Hello Daniel, Our manager Natalya the day after tomorrow will dial the driver, also we ask you yourself to the transportation company. 19/05/2024 19:50
Good afternoon, I am hoping tomorrow until 13:30 to get the UNIC 600A Tablet Press in Lyme ! Please comment. 19/05/2024 19:59
Good day, Aubrey! Our manager has communicated with the delivery service, the equipment will be delivered to Lyme at your address. Please let us know when you receive it. 19/05/2024 20:00
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 19/05/2024 20:09
Good afternoon Maya, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. tomorrow until 16:30 we will get a reply from the manufacturer on the final time frame. 19/05/2024 20:11
Vacuum powder conveyor QV-01 quantity of 3 pieces, need discount and delivery to Houston. 19/05/2024 20:19
Good day Ruby, in our catalog all prices are given including delivery to the door of the customer. If you buy 3 pieces we will make a discount of 7%. Delivery to Houston is included in the price. 19/05/2024 20:20
Mixer with paddle for powders CX-100 what is the exact packing size ? 19/05/2024 20:29
Ellie, Hello! Packing dimensions 1200x640x1000 mm, packing weight 250 kg. Please let me know when you receive the shipment. 19/05/2024 20:32
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- PERISTALTIC PUMPS DISPENSERS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COATING TABLETS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES