СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Standardization of suppositories in the pharmaceutical industry

Standardization of suppositories in the pharmaceutical industry

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Standardization of suppositories in the pharmaceutical industry

Standardization of suppositories in the pharmaceutical industry

All manufactured suppositories must meet the requirements of the State Pharmacopoeia XI: Suppositories must have a homogeneous mass. Homogeneity of suppository is checked visually on a longitudinal slice for the presence or absence of inclusions, pieces” of the basis, particles of different colors, other inclusions, while the presence of air rod is allowed. Deviations in the mass of suppositories are allowed within 5%. Suppositories should have the correct uniform shape. In suppositories, the drug substances must be accurately dosed. The suppositories must have a hardness that makes them easy to use.

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Information updated : 11 / 03 / 2026
In stock
Manufacturer : 1 year for Standardization of suppositories in the pharmaceutical industry

Model: Standardization of suppositories in the pharmaceutical industry

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The release of drugs from hydrophobic bases is slower.
When making suppositories, it should be remembered that the drug substances introduced into the composition of these dosage forms in the form of aqueous solutions, absorbed much easier and faster have a local effect than the drug substances introduced in dry form. In terms of microbiological purity of preparations for rectal administration are classified by the State Pharmacopoeia to category IIIA, ie in 1 g or 1 ml of the drug should contain no more than 1000 aerobic bacteria and 100 fungi in the absence of Escherichia coli.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

All suppositories (especially rectal and urethral) must have sufficient hardness to overcome the resistance of tissues and sphincters, otherwise the suppositories are deformed and their use becomes impossible. The melting point determined for lipophilic suppositories should not exceed 37 °C. Moreover, it is necessary that their melting occurred in a short temperature range (1-2 ° C). If the definition of melting temperature causes difficulties, then set the time of full deformation, which should be no less than 3 and no more than 15 min. For suppositories made on hydrophilic bases, determine the time of dissolution in water, which should not exceed 1 h.

Additional information

The liquid mass formed after melting or dissolution of suppositories should spontaneously spread over the mucous membrane, forming a uniform layer. This condition is necessary to ensure close contact of the drug substance with tissues and its proper absorption. Suppositories should easily release the drug substances included in them. This quality depends both on the properties of the base used for the preparation of suppositories, and on the method of introduction of drugs into the base. Hydrophilic bases (except polyethylene oxides) easily release active substances, as they are able to dissolve in the secretions of mucous membranes.

Order status tracking

Roman Tsibulsky +79853643808 now online

Elijah
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 30/03/2026 22:44

Roman Tsibulsky
Elijah, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer tomorrow until 16:30. We will report back immediately. 30/03/2026 22:48

Mia
Good day, I want In the afternoon to get FF-02 tablet and capsule filling machine in Mont St. Michel? 30/03/2026 22:54

Roman Tsibulsky
Good afternoon, Mia! We have contacted the transportation company, your shipment is arriving in Mont St. Michel without delay. Please wait for a call from a representative of Business Lines. 30/03/2026 22:57

Logan
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to Fresno. Thank you. 30/03/2026 23:04

Roman Tsibulsky
Logan, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to Fresno is scheduled for tomorrow until 15:30. Please notify us upon receipt. 30/03/2026 23:07

Michael
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 30/03/2026 23:14

Roman Tsibulsky
Hello Michael, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 30/03/2026 23:17

Noah
I've been calling your office since this morning, and no one's picking up the phone. 30/03/2026 23:24

Roman Tsibulsky
Good afternoon, Noah! The office will be open from 9:00 GMT. We'll be in touch. 30/03/2026 23:28

Aurora
Good day, delivery time of semi-automatic drum filling machine DF-10 to Figueres, will the courier call us? 30/03/2026 23:34

Roman Tsibulsky
Aurora, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 30/03/2026 23:36

Benjamin
Roman, can you tell me if my rotary tablet press RZJ-35 has been shipped yet? Don't send it yet, I will send to your factory in China drawings of new punches, different design. 30/03/2026 23:44

Roman Tsibulsky
Good afternoon, Benjamin! We're pausing the shipment. Send drawings to the office mail. The terms of production of new punches 20 working days. 30/03/2026 23:48

Eleanor
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 30/03/2026 23:54

Roman Tsibulsky
Hello Eleanor, Our manager Natalia tomorrow until 17:30 will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Oxford in 15 days. 30/03/2026 23:58

Samuel
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Cluj-Napoca, but immediately upon arrival send it to Riga. 31/03/2026 00:04

Roman Tsibulsky
Hello Samuel, we will try to resolve this issue for you. 31/03/2026 00:06

Mila
Good day, tell me need delivery in Stockton to the settlement in the distance of 20 km. Can you organize this? 31/03/2026 00:14

Roman Tsibulsky
Mila, Good afternoon, please send us an email to info@minipress.ru with the exact name of the equipment model, city, and your coordinates. We will calculate the delivery to you. 31/03/2026 00:15