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The release of drugs from hydrophobic bases is slower.
When making suppositories, it should be remembered that the drug substances introduced into the composition of these dosage forms in the form of aqueous solutions, absorbed much easier and faster have a local effect than the drug substances introduced in dry form. In terms of microbiological purity of preparations for rectal administration are classified by the State Pharmacopoeia to category IIIA, ie in 1 g or 1 ml of the drug should contain no more than 1000 aerobic bacteria and 100 fungi in the absence of Escherichia coli.
Pharmaceutical Glossary
Technical specifications
All suppositories (especially rectal and urethral) must have sufficient hardness to overcome the resistance of tissues and sphincters, otherwise the suppositories are deformed and their use becomes impossible. The melting point determined for lipophilic suppositories should not exceed 37 °C. Moreover, it is necessary that their melting occurred in a short temperature range (1-2 ° C). If the definition of melting temperature causes difficulties, then set the time of full deformation, which should be no less than 3 and no more than 15 min. For suppositories made on hydrophilic bases, determine the time of dissolution in water, which should not exceed 1 h.
Additional information
The liquid mass formed after melting or dissolution of suppositories should spontaneously spread over the mucous membrane, forming a uniform layer. This condition is necessary to ensure close contact of the drug substance with tissues and its proper absorption. Suppositories should easily release the drug substances included in them. This quality depends both on the properties of the base used for the preparation of suppositories, and on the method of introduction of drugs into the base. Hydrophilic bases (except polyethylene oxides) easily release active substances, as they are able to dissolve in the secretions of mucous membranes.
Order status tracking
Please inform me about the status of the order Rotary tablet press RZ-10A in Minneapolis ? 18/05/2024 18:20
Good afternoon, Samuel. We have contacted the carrier, delivery is scheduled in the interval from 10:00-12:00. Please let us know when you receive it. Thank you. 18/05/2024 18:21
YR-90 dry and wet powder granulator YR-90 month has already passed. Hurry up the factory. 18/05/2024 18:30
Emma, good afternoon. The factory has shipped your equipment to our representative, now is forming a consolidated shipment for shipment to customs. We will keep you informed. 18/05/2024 18:31
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled tomorrow until 17:30 to open the box and test. 18/05/2024 18:40
James, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 18/05/2024 18:44
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled tomorrow until 12:30 to open the box and test. 18/05/2024 18:50
Avery, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 18/05/2024 18:51
Run through the order. V-shaped mixer for powders VM-50 and Mechanical tablet press PP-28 are waiting. 18/05/2024 19:00
Savannah, Checking delivery status. The shipment is already in Cinque Terre warehouse. Please arrange for pickup. 18/05/2024 19:02
Dear Roman. Deadline (time) I am waiting for your quotation for a machine for removing tablets and capsules from blister packs MB-10 with delivery. 18/05/2024 19:10
Hello Aiden, By the specified time we will send the offer to your e-mail. Now we are waiting for an answer from the transportation company on the delivery time to Minneapolis . 18/05/2024 19:13
Rotary tablet press RZK-25 I want to order with delivery to Berlin 18/05/2024 19:20
Good day, Alexander We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 18/05/2024 19:20
To what address to send you samples of bottles and caps to send them to the factory ? Regards Hazel. 18/05/2024 19:30
Good day, Hazel We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 18/05/2024 19:30
Dear Roman. Deadline (time) I am waiting for your quotation for a machine for removing tablets and capsules from blister packs MB-10 with delivery. 18/05/2024 19:40
Hello Charlotte, By the specified time we will send the offer to your e-mail. Now we are waiting for an answer from the transportation company on the delivery time to Indianapolis . 18/05/2024 19:41
To what address to send you samples of bottles and caps to send them to the factory ? Regards Andrew. 18/05/2024 19:50
Good day, Andrew We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 18/05/2024 19:52
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- BOTTLE FILLING AND CAPPING EQUIPMENT
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- PERISTALTIC PUMPS DISPENSERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING