Video review of the model
Our service and customer service
Visually, the tendency of the surface of powders to wet with water is manifested by: full wetting, in which water completely spreads over the surface of the powder; partial wetting, in which water partially spreads over the surface; full non-wetting, in which a drop of water does not spread, maintaining a shape close to spherical. Hydrophobic (non-wettable by water) substances can be well wetted by other liquids, such as organic solvents. Wettability of medicine substances is important in predicting tablet disintegration. Tablets obtained by pressing well-wetted substances with water easily penetrate water, which accelerates tablet disintegration.
Hygroscopicity is the property of some substances to absorb water vapor from the air. If a powdered mass prepared for tabletting is hygroscopic, it will begin to absorb vapors from the air and dissolve in the absorbed water. If the substance is highly hygroscopic, it predetermines the use of auxiliary substances – moisture stimulants.
Crystallization water – water involved in salt composition during its crystallization (water contained in crystals, being in connection with molecules of substance in strictly defined quantities). Crystallization water molecules determine mechanical (strength, plasticity) and thermal (relation to the temperature of the medium) properties of the crystal and have a significant influence on the behavior of the crystal under pressure. The phenomenon of “cementation” is also closely related to the presence of crystallization water in tableted substances.
Pharmaceutical Glossary
Technical specifications
The size of substance particles determines the choice of tablet production technology, the method and equipment for granulation, the strength and density of the obtained granules and, accordingly, the mechanical properties of the tablets themselves, their disintegration and dissolution. For example, in JSC “Chemical-Pharmaceutical Combine “AKRIHIN” as a result of research of a large number of preparations the practical material confirming the influence of the shape and size of crystals of substances on the parameters of the technological process of obtaining tablet masses and modes of their pressing was obtained. For example, for production of aminalon core tablets only fine crystalline substance is necessary, and aminalon crystals of 500-1000 microns in size give unstable, loose tablets. Tablet dosage form of carbamazepine of proper quality by fluidized bed granulation method can be obtained from micronized substance (up to 20 μm), and by conventional wet granulation method – only from powder with particle size from 50 to 300 μm. To obtain acyclovir tablets with a high dissolution index, the particle size of the substance is standardized – not more than 50 microns. It was also found that glibenclamide tablets have good dissolution indexes only when micronized powder is used.
Especially noticeable is the influence of the shape and particle size of substances on the technological characteristics of tablet mass intended for direct pressing.
It is known that only substances belonging to the cubic system are pressed into tablets directly, i.e. by direct pressing, without granulation and auxiliary substances.
Additional information
The more complex the powder surface, the greater the adhesion and lesser the friability, and vice versa. Since direct pressing is increasingly being introduced into pharmaceutical production due to its clear economic advantages and the emergence of modern high-speed tablet presses with high pressing forces, research aimed at studying and normalizing the technological and rheological parameters of tablet mixtures, as well as their constituents, i.e. active and excipients, is particularly relevant. These studies are especially in demand nowadays, when the number of firms-suppliers of medicine substances has increased dramatically, which often differ significantly from series to series in their physicochemical and technological parameters. Specific surface area is the surface area of a solid substance (powder) referred to the unit of mass or volume. If the substance has a porous structure, the total area of all its pores is taken into account.
Contact surface – surface formed when powder particles come into contact with each other. True density is the limit of the medicine mass to volume ratio at zero powder porosity. Wettability is the ability of powdered medicine substances to interact with various liquids (lyophilicity), and above all with water (hydrophilicity). The surface of solid particles of medicine substances contains a certain number of hydrophilic groups (OH, -SON, etc.) or oxygen atoms, which are structural elements of their crystal lattice, so the wettability of the surface of powders has a different value depending on the intensity of interaction of intermolecular forces.
Order status tracking
Hello, is it possible to buy your blistering machine for tablets and capsules MN-80 1 piece with delivery to Chicago ( Europe) ? How much time for delivery ? 22/07/2024 06:11
Hannah, hello! We have many customers from your city. Delivery to this region is made by EMC. 22/07/2024 06:13
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled between 16:00-18:00 to open the box and test. 22/07/2024 06:21
Jayden, good afternoon. Great news, please send a photo and video report to WhatsApp +79853643808. 22/07/2024 06:25
We have sent to info@minipress.ru photos of the damaged box with induction welding membrane machine FG-08. Please call back. 22/07/2024 06:31
Good day, Lucy! Damage to the packaging is unfortunately a common practice in transportation. Please carefully unpack the shipment and send us a series of photos. We will take a look and take action. 22/07/2024 06:32
RZW-29 rotary tablet press in Luzern. Regards, Olivia. 22/07/2024 06:41
Olivia, Delivery will be made tomorrow until 13:30 to Luzern . Please have the movers ready. The weight of the equipment is heavy. 22/07/2024 06:44
Automatic blister packaging machine for PVC+cardboard LW-35 with delivery to Baltimore. We want to track the delivery status. 22/07/2024 06:51
Grayson, hello. The shipment has already arrived. Now it is in the warehouse of the transportation company. Your manager will contact you to clarify the time of delivery to your city. 22/07/2024 06:54
Can your technician come to Dubrovnik? We need technologist consultation and assistance. 22/07/2024 07:01
John, We have already received your email. A technician as agreed will contact you. Don't worry. 22/07/2024 07:04
LW-35 automatic PVC+cardboard blister packaging machine has been on the road for 30 days. What news ? 22/07/2024 07:11
Hello Riley, We are on time, tomorrow until 16:30 a driver will contact you about unloading. 22/07/2024 07:13
Roman, our company bought VL-100 V-shaped powder mixer, but it is not enough for us, can we return it and exchange it for V-300 model? 22/07/2024 07:21
Sophia, good afternoon. When we corresponded with you, I warned you that this is a model with a small load. Unfortunately we can not pick up the equipment. As an option, we will offer our customers with a discount. 22/07/2024 07:23
You have to pay for delivery to Sarajevo over and above the delivery amount in the contract ? 22/07/2024 07:31
Abigail, The catalog shows the price with door delivery. The unloading of the equipment, upon receipt of the shipment, will be charged to you separately. 22/07/2024 07:35
Hello, is it possible to buy your blistering machine for tablets and capsules MN-80 1 piece with delivery to New Orleans ( Europe) ? How much time for delivery ? 22/07/2024 07:41
Joseph, hello! We have many customers from your city. Delivery to this region is made by EMC. 22/07/2024 07:42
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC CARTONING MACHINES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS