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Substances containing crystallization water can be used in powders intended for subsequent dissolution. It is necessary to strictly observe the time of grinding of medicinal substances: insufficient time leads to incomplete grinding, and exceeding it may reduce the total surface area of the powder due to aggregation of ground particles. To increase the brittleness of substances, grinding with cooling is used (soaps, resins, waxy solid fats). The process is carried out with the supply of cold air after preliminary cooling in the refrigerator of the products themselves. In the case of complex powders, grinding starts with a coarse crystalline substance. Often when grinding use special techniques: for example, finer grinding of some drugs is achieved in the presence of indifferent substances (sucrose, lactose). Sometimes volatile liquids (ethanol) are added, an example is the grinding of camphor in the presence of ethanol. As the ethanol evaporates, a recrystallization phenomenon occurs and the camphor is distributed as tiny particles throughout the powder. Simple powders are obtained by thorough dry or wet grinding of dried drugs. When obtaining complex powders in factory conditions, each substance included in the mixture is milled separately and sieved through an appropriate sieve. When sieving mixtures through the openings of the sieve through the openings of the sieve pass first of all the smaller particles with a higher specific gravity, then the lighter and larger particles are sifted out. The result is a mixture of layers of different qualities, so the ingredients must be thoroughly mixed again after sieving.
Pharmaceutical Glossary
Technical specifications
Depending on this, the appropriate equipment is selected (in the first case a hammer mill is needed, in the second case a ball mill). The type of roots is also important: one type of machine is used for fibrous roots and another for non-fibrous roots. It is also necessary to take into account the moisture content of raw materials: raw materials must necessarily be dried to a residual moisture content of 6-8%. For grinding medicinal substances that form poisonous or irritating dust, use the least dusty ball mills. Grinding is carried out in separate rooms, and the mills are closed with special covers. During the grinding process, personal safety measures are applied, using special clothing for personnel. Prefabricated shredder GF-300A, used in the modern pharmaceutical industry, consists of the following components: shredder, dust collector and collector for raw materials. The principle of operation is as follows: after loading into the hopper, the raw material falls between fixed and movable toothed disks, which rotate at high speed. The raw material is transformed into powder by pulsating drilling, cutting, kneading and by pushing granules of different sizes. All working parts are made of high quality stainless steel. The grinder is manufactured in accordance with GMP standard. In the CGS jet mill from the German company NETZSCH, the grinding energy is generated by gas jets through horizontally integrated air nozzles. The gas jets create a fluidized bed in which the particles are accelerated by the gas jet. As the particles move towards the center and at the very center of the chamber, they collide with other particles moving slower, and thus comminution occurs. The air appearing in the center of the chamber “transports” the particles to the classifier, which in turn sifts out the particles that are too coarse and allows only those particles that match the settings, such as the speed of the classifier and the amount of air to pass through.
Additional information
With the CGS jet mill it is possible to achieve particle dispersities in the range of 2- /0 µm. The desired dispersity is set via a rotary classifier. Depending on the medical purpose and method of application, powders have different dispersity requirements. Crystalline powders intended to be dissolved before use by patients (e.g. magnesium sulphate, boric acid) are usually dispensed as medium, medium-fine or even coarse powders. Powder powders intended for the treatment of various injuries of the skin or mucous membranes should have a high degree of dispersibility in order to increase the total surface area of the particles of these substances and reduce their traumatic effects. For example, in calcium-containing toothpastes, calcium is in the form of fine needle-like crystals so that these crystals can fill cracks in the enamel of teeth. In the manufacture of powders, it is necessary to take into account the physicochemical properties of drugs and excipients. In the manufacture of complex powders take into account: the size and shape of crystals, solubility in ethanol, the ability to adsorb (including coloring ability), the ability to electrify (sulfur, butadione) and atomize (magnesium oxide), volatility (menthol, camphor, essential oils, etc.). Difficult to grind substances (camphor, menthol, iodine) are ground in the presence of volatile solvents – alcohol or ether, which are surfactants (10 drops of alcohol or 15 drops of ether per 1 g of substance). They facilitate the process of destruction, produce a cleaving effect and, adsorbed on the smallest particles, prevent aggregation, stabilize the powder mass. Substances with coloring properties are introduced avoiding their direct and prolonged contact with the grinding surfaces of the equipment. To avoid moistening of the powder mixture and to improve grinding, some substances (sodium and magnesium sulfates, alum) should be used dried, having previously dried them at a temperature of 40-50°C.
Order status tracking
Vacuum powder conveyor QV-01 quantity of 3 pieces, need discount and delivery to Los Angeles. 22/07/2024 06:23
Good day Leo, in our catalog all prices are given including delivery to the door of the customer. If you buy 3 pieces we will make a discount of 7%. Delivery to Los Angeles is included in the price. 22/07/2024 06:24
Hello Roman! Thank you for the service and quality of your products. We are very happy and satisfied with the purchase! 22/07/2024 06:33
Hello Mateo, Apparently you have tested your vacuum lyophilic dryer LZY-01. Its quality is above average, it will work. We are waiting for your new applications. 22/07/2024 06:36
The MZ-10 expiration date and date handheld printer has still not been delivered. The driver did not answer and dropped calls yesterday. 22/07/2024 06:43
Hello Olivia, Transportation has advised that tomorrow until 13:30 driver will definitely deliver the box to your address. We apologize. 22/07/2024 06:45
PU-420 flow-pack packaging machine along with 500 kg packaging , delivery to Memphis. Please confirm the delivery time. 22/07/2024 06:53
Good afternoon Mia, your shipment has left. Arrival time in the interval from 10:00-12:00. The driver will call you back later. Please organize prompt unloading. 22/07/2024 06:56
The BB-152 liquid filling machine arrived from you today, remember us ? Where's the paperwork? 22/07/2024 07:03
{The original shipping documents will be delivered to Edinburgh tomorrow until 17:30. Please send the signed copies to us. 22/07/2024 07:06
Please inform me about the status of the order Rotary tablet press RZ-10A in Pittsburgh ? 22/07/2024 07:13
Good afternoon, Mila. We have contacted the carrier, delivery is scheduled after lunch. Please let us know when you receive it. Thank you. 22/07/2024 07:17
Run through the order. V-shaped mixer for powders VM-50 and Mechanical tablet press PP-28 are waiting. 22/07/2024 07:23
Zoe, Checking delivery status. The shipment is already in Krakow warehouse. Please arrange for pickup. 22/07/2024 07:24
I've been calling your office since this morning, and no one's picking up the phone. 22/07/2024 07:33
Good afternoon, Sophia! The office will be open from 9:00 GMT. We'll be in touch. 22/07/2024 07:36
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Dublin ? 22/07/2024 07:43
Hello James, your shipment is in the customs warehouse, as agreed your manager Natalia will contact you. 22/07/2024 07:44
Tell me the NJ-120 automatic capsule machine went ? 22/07/2024 07:53
Jack, good afternoon. Yes, already in the morning you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 22/07/2024 07:55
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR COATING TABLETS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COATING TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION