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The most common combinations are the combination of a wet granulator-mixer with a spheronizer and an extruder with a spheronizer. Fluidized bed pelletizing. Pellets can be produced using a rotary insert in.a fluidized bed. The powder is mixed and moistened, the solvent or binder is fed tangentially. The powder layer is driven in a circular motion by the rotor insert. Process air, which is supplied through an adjustable gap at the edges of the rotor insert, drives the powder bed in a spiral motion. Agglomerates are formed which, due to the rotation of the rotor insert, are rolled into dense pellets with a regular spherical shape. The number of rotor revolutions has a direct influence on the density and size of the pellets. Drying of the wet pellets takes place either directly in the rotor during the drying phase at an elevated supply air temperature or in a fluidized bed dryer. Pellets are produced directly and very quickly from powder with the addition of a binder or solvent. The resulting pellets or pellets have a high density (comparable to the density of pellets produced in vertical pelletizers). If necessary, high-solid content shells are obtained by coating.
Pharmaceutical Glossary
Technical specifications
The particle size distribution of the resulting pellets is within a wide range of sizes. Pelletizing by rolling is the process of giving a spherical shape to extrudate after the extrusion process or to wet pellets after the wet granulation process. The spherical shaped pellets provide good stable friability and pellets with minimal mass variation are obtained. For example, in the study of granulates of calcium biphosphate, magnesium hydroxide and sulfadimezine prepared by wet granulation followed by rolling, it was found that their bulkiness increased by 40-100%. Rolling of wet pellets or extrudate is carried out on equipment called spheronizer. The principle of operation of a spheronizer is as follows: in the first stage, the material is compacted. With the help of a rotor-transfer granulator pellets are formed, which in the second stage are rolled in the spheronizer to a spherical shape and removed from the apparatus. In the presented GEA spheronizer, the plate is covered with smooth recesses. The plate is rotating and is tightly adhered to the walls of the apparatus. In this way, pellets with a good spherical shape are formed and a good particle size distribution is achieved.
Additional information
The granulate or extrudate is rolled to a spherical shape under the action of centrifugal and frictional forces. This design of the spheronizer solves the problem of material edge breakage and the appearance of unwanted small particles. Optimization of the process is achieved by selecting the rotation cycle time, plate speed, product loading and controlling the air flow around the periphery of the rotating plate. In the Glatt spheronizer, wet pelletized products or pre-formed extrudates are fed onto a rotating disk for pelletizing. The rotation of the disk, the flow of incoming product and a jet of air supplied through a slit in the side wall create an orderly product movement in a spiral path at the vessel wall. Due to intensive rolling, the surface of the particles is smoothed to form pellets. The dust particles generated in this process are captured again by the resulting pellets directly in the process. To increase the throughput capacity of the equipment in batch operation, several spheronizers are combined in a cascade. The cascade principle is also used to produce pellets with a laminated structure. The structure of the pellets is determined by the granulation process that takes place earlier in the process chain.
Order status tracking
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 05/12/2025 15:41
Logan, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer tomorrow until 15:30. We will report back immediately. 05/12/2025 15:45
You have to pay for delivery to Lucca over and above the delivery amount in the contract ? 05/12/2025 15:51
Lily, The catalog shows the price with door delivery. The unloading of the equipment, upon receipt of the shipment, will be charged to you separately. 05/12/2025 15:52
Good afternoon, please confirm that after lunch we will receive our shipment in Amsterdam? Contact the transportation company. 05/12/2025 16:01
Hello Violet ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Amsterdam in a few days. Please expect it. 05/12/2025 16:02
I've been calling your office since this morning, and no one's picking up the phone. 05/12/2025 16:11
Good afternoon, Samuel! The office will be open from 9:00 GMT. We'll be in touch. 05/12/2025 16:14
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Bordeaux, but immediately upon arrival send it to Monte Carlo. 05/12/2025 16:21
Hello Eleanor, we will try to resolve this issue for you. 05/12/2025 16:23
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled tomorrow until 18: 30 to open the box and test. 05/12/2025 16:31
Luna, good afternoon. Great news, please send a photo and video report to WhatsApp +79853643808. 05/12/2025 16:33
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 05/12/2025 16:41
Hello James, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 05/12/2025 16:42
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Florence, do you deliver to the terminal or to the actual address? 05/12/2025 16:51
Hello Victoria, we ship all over Europe and the US including to Florence . The price in the catalog includes any delivery our customer asks for. 05/12/2025 16:53
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 05/12/2025 17:01
Lily, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Omaha ? Contact Natalia, she will send the contract and invoice. 05/12/2025 17:05
HX-6 Plastic Tube Filling and Sealing Machine in Crete? Price delivery terms and conditions 05/12/2025 17:11
Luna, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 05/12/2025 17:13
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
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