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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / PHARMACEUTICAL PELLET MICROSPHERES / Technologies of pellet production and equipment used

Technologies of pellet production and equipment used

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / PHARMACEUTICAL PELLET MICROSPHERES / Technologies of pellet production and equipment used

Technologies of pellet production and equipment used

Pellets (microspheres) are produced by several methods: direct pelletizing, rolling pelletizing, fluidized bed pelletizing, layering pelletizing. Pellets (microspheres) are produced in several ways: direct pelletizing, rolling pelletizing, fluidized bed pelletizing, layering pelletizing.
Direct pelletizing involves creating pellets directly from powder with a binder or solvent. It is a fairly fast process that requires a small amount of auxiliaries. In the initial stage, the powder is mixed and moistened. The solvent or binder is then added as required and sprayed onto the powder particles. The powder layer is driven in a circular motion. The resulting collisions and accelerations produce agglomerates, which are pelletized to produce dense pellets with a regular spherical shape. The speed of rotation has a direct effect on the density and size of the pellets.
The wet pellets are then dried in a fluidized bed. The advantage of the direct pelletizing process is to obtain round pellets with good flowability, dosability, dispersibility, compact structure, high bulk weight, dense surface and high abrasion resistance.

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  • Information updated : 09 / 12 / 2024
  • In stock
  • Manufacturer : 1 year for Technologies of pellet production and equipment used

Model: Pellet production

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The most common combinations are the combination of a wet granulator-mixer with a spheronizer and an extruder with a spheronizer. Fluidized bed pelletizing. Pellets can be produced using a rotary insert in.a fluidized bed. The powder is mixed and moistened, the solvent or binder is fed tangentially. The powder layer is driven in a circular motion by the rotor insert. Process air, which is supplied through an adjustable gap at the edges of the rotor insert, drives the powder bed in a spiral motion. Agglomerates are formed which, due to the rotation of the rotor insert, are rolled into dense pellets with a regular spherical shape. The number of rotor revolutions has a direct influence on the density and size of the pellets. Drying of the wet pellets takes place either directly in the rotor during the drying phase at an elevated supply air temperature or in a fluidized bed dryer. Pellets are produced directly and very quickly from powder with the addition of a binder or solvent. The resulting pellets or pellets have a high density (comparable to the density of pellets produced in vertical pelletizers). If necessary, high-solid content shells are obtained by coating.

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Technical specifications

The particle size distribution of the resulting pellets is within a wide range of sizes. Pelletizing by rolling is the process of giving a spherical shape to extrudate after the extrusion process or to wet pellets after the wet granulation process. The spherical shaped pellets provide good stable friability and pellets with minimal mass variation are obtained. For example, in the study of granulates of calcium biphosphate, magnesium hydroxide and sulfadimezine prepared by wet granulation followed by rolling, it was found that their bulkiness increased by 40-100%. Rolling of wet pellets or extrudate is carried out on equipment called spheronizer. The principle of operation of a spheronizer is as follows: in the first stage, the material is compacted. With the help of a rotor-transfer granulator pellets are formed, which in the second stage are rolled in the spheronizer to a spherical shape and removed from the apparatus. In the presented GEA spheronizer, the plate is covered with smooth recesses. The plate is rotating and is tightly adhered to the walls of the apparatus. In this way, pellets with a good spherical shape are formed and a good particle size distribution is achieved.

Additional information

The granulate or extrudate is rolled to a spherical shape under the action of centrifugal and frictional forces. This design of the spheronizer solves the problem of material edge breakage and the appearance of unwanted small particles. Optimization of the process is achieved by selecting the rotation cycle time, plate speed, product loading and controlling the air flow around the periphery of the rotating plate. In the Glatt spheronizer, wet pelletized products or pre-formed extrudates are fed onto a rotating disk for pelletizing. The rotation of the disk, the flow of incoming product and a jet of air supplied through a slit in the side wall create an orderly product movement in a spiral path at the vessel wall. Due to intensive rolling, the surface of the particles is smoothed to form pellets. The dust particles generated in this process are captured again by the resulting pellets directly in the process. To increase the throughput capacity of the equipment in batch operation, several spheronizers are combined in a cascade. The cascade principle is also used to produce pellets with a laminated structure. The structure of the pellets is determined by the granulation process that takes place earlier in the process chain.

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