СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Preparation of suppository base

Preparation of suppository base

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Preparation of suppository base

Preparation of suppository base

The stage of preparation of the suppository base begins with the sizing of its components. In the first stainless steel reactor with a steam jacket melt paraffin, in the second reactor melt hydrofat by supplying steam into the steam jacket. The heated hydrofat is transferred to the reactor with pre-melted paraffin by means of a pump. The mixture is heated to a temperature of 60-70 ° C and cocoa butter is added. In order to avoid changes in the modification of cocoa butter, heating should not exceed 70 ° C and be prolonged. After complete melting of the base it is stirred for 40 min with a stirrer. The melting point and the time of complete deformation are determined in the finished base.

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Information updated: 07 / 05 / 2026
Available for
Production: 1 year на оборудование для приготовления суппозиторной основы

Model: Suppository base

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The preparation of the suppository mass is carried out in a reactor, where the ready base is fed with compressed air and drug substances are added. As an example, the LT series reactor-mixer manufactured by the Italian company ZUMA s.r.l. is used. Mixers of this series are designed for the preparation of suppository mass, creams, ointments, etc. and are available in four sizes with the volume of the working tank 30, 60, 140 and 250 liters. The working tank of the reactor is a polished stainless steel tank with a water jacket for heating and melting of the mixture. The tank can be rotated by 90° for easy draining and washing. The agitator blades of the reactor are equipped with scraper blades. All working parts of the apparatus are made of stainless steel. The mixer reactor is equipped with safety guards and is manufactured according to international standard.

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Technical specifications

If the melting temperature of the base is higher or lower than the specified one, then paraffin or hydrofat is introduced into the base heated to 60-70 ° C with thorough mixing. The base is filtered through a druk-filter using a brass mesh or belting, analyzed by melting temperature, solidification and time of full deformation and transferred to the apparatus department.
Druk filters are pressurized capacitive filters. Druk-filters are vertical vessels (usually with a jacket) with an elliptical bottom.
The vessel filter housing can be open or closed. The upper part of the housing is fed with the slurry to be separated. The filtrate is discharged from the lower part. During filtration, compressed gas is fed into the slurry-filled housing.

Additional information

The filter baffle is located on the false bottom. The resulting sludge is washed, dried and discharged by means of an agitator through a hatch located on the side of the housing or in the center of the false bottom. In some designs, the sludge is removed after lowering the false bottom by moving the filter cloth belt, which passes through the regeneration chamber at the end of the sludge discharge. Druk filters are known, the body of which can be rotated by 90-180° in the trunnions fixed on its cylindrical part. Druk filters are used to separate medium and well-filtered suspensions in medium and low-tonnage productions.

Order status tracking

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Mia
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 14/05/2026 09:53

Roman Tsibulsky
Hello Mia, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 14/05/2026 09:55

John
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled in the morning to open the box and test. 14/05/2026 10:03

Roman Tsibulsky
John, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 14/05/2026 10:05

Victoria
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Tbilisi ? 14/05/2026 10:13

Roman Tsibulsky
Hello Victoria, your shipment is in the customs warehouse, the day after tomorrow your manager Natalia will contact you. 14/05/2026 10:15

Avery
YR-90 dry and wet powder granulator YR-90 month has already passed. Hurry up the factory. 14/05/2026 10:23

Roman Tsibulsky
Avery, good afternoon. The factory has shipped your equipment to our representative, now is forming a consolidated shipment for shipment to customs. We will keep you informed. 14/05/2026 10:26

Stella
Vacuum powder conveyor QV-01 quantity of 3 pieces, need discount and delivery to Louisville. 14/05/2026 10:33

Roman Tsibulsky
Good day Stella, in our catalog all prices are given including delivery to the door of the customer. If you buy 3 pieces we will make a discount of 7%. Delivery to Louisville is included in the price. 14/05/2026 10:34

Brooklyn
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Prague, then I want to buy an automatic capsule machine model GN-28 14/05/2026 10:43

Roman Tsibulsky
Good afternoon, Brooklyn! On the first question - the shipment will arrive in Prague In the afternoon. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 14/05/2026 10:46

Zoe
Roman hello, what about the automatic filling and sealing machine for sterile ampoules ABF-4D-1, invoice #101. 14/05/2026 10:53

Roman Tsibulsky
Good afternoon, Zoe! We are making a request to the manufacturer. Tomorrow we will send photos and video of testing to your e-mail. 14/05/2026 10:57

Alexander
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 14/05/2026 11:03

Roman Tsibulsky
Alexander, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer tomorrow until 15:30. We will report back immediately. 14/05/2026 11:03

Samuel
Mixer with paddle for powders CX-100 what is the exact packing size ? 14/05/2026 11:13

Roman Tsibulsky
Samuel, Hello! Packing dimensions 1200x640x1000 mm, packing weight 250 kg. Please let me know when you receive the shipment. 14/05/2026 11:15

William
Roman, our company bought VL-100 V-shaped powder mixer, but it is not enough for us, can we return it and exchange it for V-300 model? 14/05/2026 11:23

Roman Tsibulsky
William, good afternoon. When we corresponded with you, I warned you that this is a model with a small load. Unfortunately we can not pick up the equipment. As an option, we will offer our customers with a discount. 14/05/2026 11:25