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Fragments or dust generated by friction, damage or destruction of particles are deposited on the larger microspheres. Dust formation and subsequent bonding and layering continue until the number of favorable collisions begins to decrease rapidly, resulting in a decrease in the growth rate of the microspheres. At this point, the third stage of pelletizing, the microsphere growth stage, begins. The main mechanism of this stage, which affects the slow growth of agglomerates, is frictional material transfer, involving the transfer of material from one pellet to another in either direction. There is no change in the total number or mass of particles during this stage.
Pharmaceutical Glossary
Technical specifications
Nucleus formation is a common mechanism in all pellet formation processes – pelletization/granulation and occurs when the powder is wetted. The primary particles are connected to each other to form three-phase nuclei (air – water – particle) by means of liquid bridges. The strength of the bonding increases as the size of the -particle decreases. The size of the primary particles, their moisture content, the viscosity of the bonding particles, the wettability of the material and the processing conditions (mixing and drying rate) influence the size of the nuclei and the degree of nuclei formation. The mass and number of nuclei in the system are important characteristics of the nuclei formation stage and change in time.
Additional information
The nucleus formation stage is followed by a transition phase in which bonding and layering are involved as mechanisms of microsphere growth. Coupling is defined as the formation of larger particles by random collisions of the formed nuclei with a small excess moisture on the nucleus surface. Although the number of nuclei gradually decreases, the total mass of the system remains constant during this stage. Overlaying is a slow mechanism of microsphere growth involving the sequential attachment of fragments and dust to already formed nuclei. During layering, the number of particles remains the same while the total mass of the system increases.
Order status tracking
Run through the order. V-shaped mixer for powders VM-50 and Mechanical tablet press PP-28 are waiting. 21/01/2025 23:23
Sophia, Checking delivery status. The shipment is already in Split warehouse. Please arrange for pickup. 21/01/2025 23:23
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled as agreed to open the box and test. 21/01/2025 23:33
Zoey, good afternoon. Great news, please send a photo and video report to WhatsApp +79853643808. 21/01/2025 23:36
Hello Roman! Thank you for the service and quality of your products. We are very happy and satisfied with the purchase! 21/01/2025 23:43
Hello Ruby, Apparently you have tested your vacuum lyophilic dryer LZY-01. Its quality is above average, it will work. We are waiting for your new applications. 21/01/2025 23:47
Remember me? There's a delivery in the Saint Petersburg 21/01/2025 23:53
Lucy, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be In the afternoon in Saint Petersburg . 21/01/2025 23:56
Natalia tell me, automatic double-sided labeling machine ST-36 has left the factory, invoice #118. 22/01/2025 00:03
Hello Evelyn, The equipment has been shipped from the transit warehouse and delivery is proceeding as planned. No delays are expected. 22/01/2025 00:06
Dear Roman, good afternoon, vacuum powder conveyors QV-05 in quantity of 4 pieces, already on their way to Valletta ? 22/01/2025 00:13
Good afternoon, Andrew! Our manager has sent a scan of the bill of lading to your email. The shipment is on its way. 22/01/2025 00:15
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in Milwaukee 22/01/2025 00:23
Hello Aiden, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 22/01/2025 00:26
Mixer with paddle for powders CX-100 what is the exact packing size ? 22/01/2025 00:33
Violet, Hello! Packing dimensions 1200x640x1000 mm, packing weight 250 kg. Please let me know when you receive the shipment. 22/01/2025 00:36
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 22/01/2025 00:43
Hello Harper, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 22/01/2025 00:45
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled tomorrow until 18: 30 to open the box and test. 22/01/2025 00:53
Mia, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 22/01/2025 00:54
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR COATING TABLETS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR COATING TABLETS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES