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Fragments or dust generated by friction, damage or destruction of particles are deposited on the larger microspheres. Dust formation and subsequent bonding and layering continue until the number of favorable collisions begins to decrease rapidly, resulting in a decrease in the growth rate of the microspheres. At this point, the third stage of pelletizing, the microsphere growth stage, begins. The main mechanism of this stage, which affects the slow growth of agglomerates, is frictional material transfer, involving the transfer of material from one pellet to another in either direction. There is no change in the total number or mass of particles during this stage.
Pharmaceutical Glossary
Technical specifications
Nucleus formation is a common mechanism in all pellet formation processes – pelletization/granulation and occurs when the powder is wetted. The primary particles are connected to each other to form three-phase nuclei (air – water – particle) by means of liquid bridges. The strength of the bonding increases as the size of the -particle decreases. The size of the primary particles, their moisture content, the viscosity of the bonding particles, the wettability of the material and the processing conditions (mixing and drying rate) influence the size of the nuclei and the degree of nuclei formation. The mass and number of nuclei in the system are important characteristics of the nuclei formation stage and change in time.
Additional information
The nucleus formation stage is followed by a transition phase in which bonding and layering are involved as mechanisms of microsphere growth. Coupling is defined as the formation of larger particles by random collisions of the formed nuclei with a small excess moisture on the nucleus surface. Although the number of nuclei gradually decreases, the total mass of the system remains constant during this stage. Overlaying is a slow mechanism of microsphere growth involving the sequential attachment of fragments and dust to already formed nuclei. During layering, the number of particles remains the same while the total mass of the system increases.
Order status tracking
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Munich, do you deliver to the terminal or to the actual address? 04/04/2026 01:01
Hello Benjamin, we ship all over Europe and the US including to Munich . The price in the catalog includes any delivery our customer asks for. 04/04/2026 01:03
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 04/04/2026 01:11
Samuel, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer closer to evening. We will report back immediately. 04/04/2026 01:13
Can your technician come to Dubrovnik? We need technologist consultation and assistance. 04/04/2026 01:21
Violet, We have already received your email. A technician tomorrow until 14:30 will contact you. Don't worry. 04/04/2026 01:22
The MZ-10 expiration date and date handheld printer has still not been delivered. The driver did not answer and dropped calls yesterday. 04/04/2026 01:31
Hello Violet, Transportation has advised that closer to evening driver will definitely deliver the box to your address. We apologize. 04/04/2026 01:32
To what address to send you samples of bottles and caps to send them to the factory ? Regards Victoria. 04/04/2026 01:41
Good day, Victoria We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 04/04/2026 01:43
We have sent to info@minipress.ru photos of the damaged box with induction welding membrane machine FG-08. Please call back. 04/04/2026 01:51
Good day, Elijah! Damage to the packaging is unfortunately a common practice in transportation. Please carefully unpack the shipment and send us a series of photos. We will take a look and take action. 04/04/2026 01:55
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Reykjavik ? 04/04/2026 02:01
Hello Maya, Expect tomorrow until 18: 30. Once received, please let us know. 04/04/2026 02:04
Good afternoon, I am hoping the day after tomorrow to get the UNIC 600A Tablet Press in Sigisoara ! Please comment. 04/04/2026 02:11
Good day, Lucy! Our manager has communicated with the delivery service, the equipment will be delivered to Sigisoara at your address. Please let us know when you receive it. 04/04/2026 02:14
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 04/04/2026 02:21
Hello Alexander, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 04/04/2026 02:23
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Dublin ? 04/04/2026 02:31
Hello Elijah, Expect tomorrow until 16:30. Once received, please let us know. 04/04/2026 02:32
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
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