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Pelletizing in pharmaceutical production

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / PHARMACEUTICAL PELLET MICROSPHERES / Pelletizing in pharmaceutical production

Pelletizing in pharmaceutical production

To study the formation of pellets (microspheres), it is necessary to understand the mechanisms of pellet formation and growth. Some theories have been derived from experimental data, while others have been inferred from visual observations. Conventional granulation as the most fully studied and categorized process of microsphere formation, conducted using different equipment, has been divided into three successive stages: core formation stage, transition stage, and sphere growth stage. However, based on experiments on the mechanism of microsphere formation and growth, the following microsphere growth mechanisms have been proposed: nucleus formation, bonding, layering and friction transfer.

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Information updated : 09 / 02 / 2026
In stock
Manufacturer : 1 year for Pelletizing in pharmaceutical production

Model: Pelletizing in pharmaceutical production

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Fragments or dust generated by friction, damage or destruction of particles are deposited on the larger microspheres. Dust formation and subsequent bonding and layering continue until the number of favorable collisions begins to decrease rapidly, resulting in a decrease in the growth rate of the microspheres. At this point, the third stage of pelletizing, the microsphere growth stage, begins. The main mechanism of this stage, which affects the slow growth of agglomerates, is frictional material transfer, involving the transfer of material from one pellet to another in either direction. There is no change in the total number or mass of particles during this stage.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

Nucleus formation is a common mechanism in all pellet formation processes – pelletization/granulation and occurs when the powder is wetted. The primary particles are connected to each other to form three-phase nuclei (air – water – particle) by means of liquid bridges. The strength of the bonding increases as the size of the -particle decreases. The size of the primary particles, their moisture content, the viscosity of the bonding particles, the wettability of the material and the processing conditions (mixing and drying rate) influence the size of the nuclei and the degree of nuclei formation. The mass and number of nuclei in the system are important characteristics of the nuclei formation stage and change in time.

Additional information

The nucleus formation stage is followed by a transition phase in which bonding and layering are involved as mechanisms of microsphere growth. Coupling is defined as the formation of larger particles by random collisions of the formed nuclei with a small excess moisture on the nucleus surface. Although the number of nuclei gradually decreases, the total mass of the system remains constant during this stage. Overlaying is a slow mechanism of microsphere growth involving the sequential attachment of fragments and dust to already formed nuclei. During layering, the number of particles remains the same while the total mass of the system increases.

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Mia
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Krakow ? 22/02/2026 12:19

Roman Tsibulsky
Hello Mia, your shipment is in the customs warehouse, as stipulated in the contract your manager Natalia will contact you. 22/02/2026 12:20

Liam
Dear Roman, good afternoon, vacuum powder conveyors QV-05 in quantity of 4 pieces, already on their way to Marburg ? 22/02/2026 12:29

Roman Tsibulsky
Good afternoon, Liam! Our manager has sent a scan of the bill of lading to your email. The shipment is on its way. 22/02/2026 12:29

Amelia
We're from New Jersey, we paid for the equipment on your invoice yesterday. Has the payment been received? How long will it take to deliver to us? 22/02/2026 12:39

Roman Tsibulsky
Amelia, hello. Payment is credited to our settlement account. Term of manufacture of your equipment by the factory 20 working days, delivery from the factory to our warehouse in the USA 1 month, delivery from the warehouse in Dallas 15 calendar days. 22/02/2026 12:40

Ruby
Good day, tell me need delivery in San Francisco to the settlement in the distance of 20 km. Can you organize this? 22/02/2026 12:49

Roman Tsibulsky
Ruby, Good afternoon, please send us an email to info@minipress.ru with the exact name of the equipment model, city, and your coordinates. We will calculate the delivery to you. 22/02/2026 12:51

Isabella
PU-420 flow-pack packaging machine along with 500 kg packaging , delivery to Omaha. Please confirm the delivery time. 22/02/2026 12:59

Roman Tsibulsky
Good afternoon Isabella, your shipment has left. Arrival time in the morning. The driver will call you back later. Please organize prompt unloading. 22/02/2026 13:00

David
We're from New Jersey, we paid for the equipment on your invoice yesterday. Has the payment been received? How long will it take to deliver to us? 22/02/2026 13:09

Roman Tsibulsky
David, hello. Payment is credited to our settlement account. Term of manufacture of your equipment by the factory 20 working days, delivery from the factory to our warehouse in the USA 1 month, delivery from the warehouse in Miami 15 calendar days. 22/02/2026 13:12

Skylar
Rotary tablet press RZK-25 I want to order with delivery to Berlin 22/02/2026 13:19

Roman Tsibulsky
Good day, Skylar We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 22/02/2026 13:22

Zoey
The MZ-10 expiration date and date handheld printer has still not been delivered. The driver did not answer and dropped calls yesterday. 22/02/2026 13:29

Roman Tsibulsky
Hello Zoey, Transportation has advised that between 16:00-18:00 driver will definitely deliver the box to your address. We apologize. 22/02/2026 13:31

Ella
Run through the order. V-shaped mixer for powders VM-50 and Mechanical tablet press PP-28 are waiting. 22/02/2026 13:39

Roman Tsibulsky
Ella, Checking delivery status. The shipment is already in Tbilisi warehouse. Please arrange for pickup. 22/02/2026 13:42

Charlotte
Good day, tell me need delivery in St. Louis to the settlement in the distance of 20 km. Can you organize this? 22/02/2026 13:49

Roman Tsibulsky
Charlotte, Good afternoon, please send us an email to info@minipress.ru with the exact name of the equipment model, city, and your coordinates. We will calculate the delivery to you. 22/02/2026 13:50