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Pelletizing in pharmaceutical production

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / PHARMACEUTICAL PELLET MICROSPHERES / Pelletizing in pharmaceutical production

Pelletizing in pharmaceutical production

To study the formation of pellets (microspheres), it is necessary to understand the mechanisms of pellet formation and growth. Some theories have been derived from experimental data, while others have been inferred from visual observations. Conventional granulation as the most fully studied and categorized process of microsphere formation, conducted using different equipment, has been divided into three successive stages: core formation stage, transition stage, and sphere growth stage. However, based on experiments on the mechanism of microsphere formation and growth, the following microsphere growth mechanisms have been proposed: nucleus formation, bonding, layering and friction transfer.

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Information updated : 28 / 01 / 2026
In stock
Manufacturer : 1 year for Pelletizing in pharmaceutical production

Model: Pelletizing in pharmaceutical production

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Fragments or dust generated by friction, damage or destruction of particles are deposited on the larger microspheres. Dust formation and subsequent bonding and layering continue until the number of favorable collisions begins to decrease rapidly, resulting in a decrease in the growth rate of the microspheres. At this point, the third stage of pelletizing, the microsphere growth stage, begins. The main mechanism of this stage, which affects the slow growth of agglomerates, is frictional material transfer, involving the transfer of material from one pellet to another in either direction. There is no change in the total number or mass of particles during this stage.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

Nucleus formation is a common mechanism in all pellet formation processes – pelletization/granulation and occurs when the powder is wetted. The primary particles are connected to each other to form three-phase nuclei (air – water – particle) by means of liquid bridges. The strength of the bonding increases as the size of the -particle decreases. The size of the primary particles, their moisture content, the viscosity of the bonding particles, the wettability of the material and the processing conditions (mixing and drying rate) influence the size of the nuclei and the degree of nuclei formation. The mass and number of nuclei in the system are important characteristics of the nuclei formation stage and change in time.

Additional information

The nucleus formation stage is followed by a transition phase in which bonding and layering are involved as mechanisms of microsphere growth. Coupling is defined as the formation of larger particles by random collisions of the formed nuclei with a small excess moisture on the nucleus surface. Although the number of nuclei gradually decreases, the total mass of the system remains constant during this stage. Overlaying is a slow mechanism of microsphere growth involving the sequential attachment of fragments and dust to already formed nuclei. During layering, the number of particles remains the same while the total mass of the system increases.

Order status tracking

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Scarlett
Horizontal granulator for organic fertilizers JU-80, the price is up to date ? Delivery time to Porto? Urgent. 01/02/2026 16:48

Roman Tsibulsky
Scarlett, Please read carefully the description of this model in our catalog. Prices are current. Timing 1-1.5 months. 01/02/2026 16:52

Elijah
Tell me the NJ-120 automatic capsule machine went ? 01/02/2026 16:58

Roman Tsibulsky
Elijah, good afternoon. Yes, already the day after tomorrow you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 01/02/2026 17:00

Natalie
Granulator for wet granulation ZL-25 and Mixer V-shaped for powders VM-05 under contract No. 15 inform. 01/02/2026 17:08

Roman Tsibulsky
Hello Natalie, The shipment has arrived at the customs terminal, tomorrow until 12:30 is scheduled to be transferred to the transportation company. 01/02/2026 17:12

Ruby
Please inform me about the status of the order Rotary tablet press RZ-10A in D.C. ? 01/02/2026 17:18

Roman Tsibulsky
Good afternoon, Ruby. We have contacted the carrier, delivery is scheduled as stipulated in the contract. Please let us know when you receive it. Thank you. 01/02/2026 17:22

Matthew
Natalia tell me, automatic double-sided labeling machine ST-36 has left the factory, invoice #118. 01/02/2026 17:28

Roman Tsibulsky
Hello Matthew, The equipment has been shipped from the transit warehouse and delivery is proceeding as planned. No delays are expected. 01/02/2026 17:30

Gabriel
Hello, is it possible to buy your blistering machine for tablets and capsules MN-80 1 piece with delivery to D.C. ( Europe) ? How much time for delivery ? 01/02/2026 17:38

Roman Tsibulsky
Gabriel, hello! We have many customers from your city. Delivery to this region is made by EMC. 01/02/2026 17:42

Brooklyn
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 01/02/2026 17:48

Roman Tsibulsky
Good afternoon Brooklyn, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. tomorrow until 13:30 we will get a reply from the manufacturer on the final time frame. 01/02/2026 17:52

Gabriel
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in St. Gallen. 01/02/2026 17:58

Roman Tsibulsky
Hello Gabriel, Delivery status checked, tomorrow until 18: 30 is arriving at St. Gallen . The driver will call you beforehand. 01/02/2026 18:00

Aiden
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Zurich, do you deliver to the terminal or to the actual address? 01/02/2026 18:08

Roman Tsibulsky
Hello Aiden, we ship all over Europe and the US including to Zurich . The price in the catalog includes any delivery our customer asks for. 01/02/2026 18:09

Ella
You have to pay for delivery to Bordeaux over and above the delivery amount in the contract ? 01/02/2026 18:18

Roman Tsibulsky
Ella, The catalog shows the price with door delivery. The unloading of the equipment, upon receipt of the shipment, will be charged to you separately. 01/02/2026 18:20