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Pelletizing in pharmaceutical production

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / PHARMACEUTICAL PELLET MICROSPHERES / Pelletizing in pharmaceutical production

Pelletizing in pharmaceutical production

To study the formation of pellets (microspheres), it is necessary to understand the mechanisms of pellet formation and growth. Some theories have been derived from experimental data, while others have been inferred from visual observations. Conventional granulation as the most fully studied and categorized process of microsphere formation, conducted using different equipment, has been divided into three successive stages: core formation stage, transition stage, and sphere growth stage. However, based on experiments on the mechanism of microsphere formation and growth, the following microsphere growth mechanisms have been proposed: nucleus formation, bonding, layering and friction transfer.

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Information updated : 09 / 12 / 2025
In stock
Manufacturer : 1 year for Pelletizing in pharmaceutical production

Model: Pelletizing in pharmaceutical production

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Fragments or dust generated by friction, damage or destruction of particles are deposited on the larger microspheres. Dust formation and subsequent bonding and layering continue until the number of favorable collisions begins to decrease rapidly, resulting in a decrease in the growth rate of the microspheres. At this point, the third stage of pelletizing, the microsphere growth stage, begins. The main mechanism of this stage, which affects the slow growth of agglomerates, is frictional material transfer, involving the transfer of material from one pellet to another in either direction. There is no change in the total number or mass of particles during this stage.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

Nucleus formation is a common mechanism in all pellet formation processes – pelletization/granulation and occurs when the powder is wetted. The primary particles are connected to each other to form three-phase nuclei (air – water – particle) by means of liquid bridges. The strength of the bonding increases as the size of the -particle decreases. The size of the primary particles, their moisture content, the viscosity of the bonding particles, the wettability of the material and the processing conditions (mixing and drying rate) influence the size of the nuclei and the degree of nuclei formation. The mass and number of nuclei in the system are important characteristics of the nuclei formation stage and change in time.

Additional information

The nucleus formation stage is followed by a transition phase in which bonding and layering are involved as mechanisms of microsphere growth. Coupling is defined as the formation of larger particles by random collisions of the formed nuclei with a small excess moisture on the nucleus surface. Although the number of nuclei gradually decreases, the total mass of the system remains constant during this stage. Overlaying is a slow mechanism of microsphere growth involving the sequential attachment of fragments and dust to already formed nuclei. During layering, the number of particles remains the same while the total mass of the system increases.

Order status tracking

Roman Tsibulsky +79853643808 now online

Emily
The BB-152 liquid filling machine arrived from you today, remember us ? Where's the paperwork? 23/12/2025 09:30

Roman Tsibulsky
{The original shipping documents will be delivered to Frankfurt tomorrow until 16:30. Please send the signed copies to us. 23/12/2025 09:30

Sofia
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 23/12/2025 09:40

Roman Tsibulsky
Sofia, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer in the morning. We will report back immediately. 23/12/2025 09:44

Michael
RZW-29 rotary tablet press in Zagreb. Regards, Michael. 23/12/2025 09:50

Roman Tsibulsky
Michael, Delivery will be made between 16:00-18:00 to Zagreb . Please have the movers ready. The weight of the equipment is heavy. 23/12/2025 09:54

Aria
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Tournai. 23/12/2025 10:00

Roman Tsibulsky
Hello Aria, Delivery status checked, tomorrow until 15:30 is arriving at Tournai . The driver will call you beforehand. 23/12/2025 10:02

Michael
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Rovinj, but immediately upon arrival send it to Budapest. 23/12/2025 10:10

Roman Tsibulsky
Hello Michael, we will try to resolve this issue for you. 23/12/2025 10:11

Lily
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled tomorrow by lunchtime to open the box and test. 23/12/2025 10:20

Roman Tsibulsky
Lily, good afternoon. Great news, please send a photo and video report to WhatsApp +79853643808. 23/12/2025 10:23

Andrew
LW-35 automatic PVC+cardboard blister packaging machine has been on the road for 30 days. What news ? 23/12/2025 10:30

Roman Tsibulsky
Hello Andrew, We are on time, between 16:00-18:00 a driver will contact you about unloading. 23/12/2025 10:33

Evelyn
Good afternoon! semi-automatic liquid filling machine in barrels DF-13 , a copy of the payment is sent to the post. Start the order to work. 23/12/2025 10:40

Roman Tsibulsky
Evelyn, good afternoon! We have seen your payment, we receive SMS from the bank. Please send drawings of barrels and answers to our questions in correspondence. 23/12/2025 10:42

Daniel
Dear Roman, good afternoon, vacuum powder conveyors QV-05 in quantity of 4 pieces, already on their way to Korcula ? 23/12/2025 10:50

Roman Tsibulsky
Good afternoon, Daniel! Our manager has sent a scan of the bill of lading to your email. The shipment is on its way. 23/12/2025 10:52

Zoey
Contract #12, the deadline for delivery has already passed. Take action at last. Accelerate Tsibulsky R.G. 23/12/2025 11:00

Roman Tsibulsky
Hello Zoey, we are on vacation on weekends and are not able to respond to messages. Raise the contract, delivery time of equipment to your warehouse in Cinque Terre to 50 working ( not calendar) days. Action taken. 23/12/2025 11:00