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This process is usually used to increase the dissolution rate of the active ingredient and consequently increase the bioavailability of poorly soluble drug substances. Solidification is a process in which the drug is melted, dissolved or dispersed in hot resins, waxes or fatty acids and atomized in an air chamber where the temperature is maintained below the melting point of the formulation components to produce solidified microspheres. Depending on the physicochemical properties of the components, and the loading composition, this process can produce microspheres with conventional or modified release. Compression is one of the compaction technologies to produce microspheres. By compressing a mixture of active ingredients and excipients under pressure, microspheres of specific sizes and shapes can be obtained. The composition of the loading and the process conditions controlling the quality of the finished microspheres are similar to the parameters for the production of tablets.
Pharmaceutical Glossary
Technical specifications
A variety of layers with different characteristics can be applied. Pellets obtained by this technology have many positive characteristics such as spherical shape, good flowability, dosability, compact structure, low hygroscopicity, high bulk weight, dense and homogeneous surface layer, narrow particle size distribution, high resistance. External to abrasion, the ability to incorporate a large number of species of multilayer bioactive substances and optimal initial pellet shape for subsequent coating. With the rotor method, it is possible to apply the film in very thick layers. Pellets containing large amounts of bioactive substances (when necessary) can be produced with this technology. In layer-by-layer pelletizing, the biologically active substance can be: sprayed onto the initial nuclei as a solution with a concentration of up to 50%; sprayed as a suspension; dosed in powder form in combination with a solvent and binder feed.
Additional information
In this case, the mass gain during layer-by-layer pelletizing in the rotor can be up to 10-fold of the initial mass. The layering of drug on microspheres is also carried out in centrifugal granulators, which can be used to obtain multi-element products with conventional or modified drug release. Using such systems, the primary granules can be prepared, drug substance layered and coated in the same, equipment to produce spherical multilayer granules with the desired drug substance release. In addition to the methods described above, which are the most common, other methods of producing microspheres such as globulation, solidification and compression are used to a limited extent in the pharmaceutical industry. Globulation consists of two related processes: spray drying and solidification. Spray drying is a process in which a suspension or solution of a drug substance without excipients is atomized in a stream of hot air to produce dry spherical particles.
Order status tracking
Vacuum powder conveyor QV-01 quantity of 3 pieces, need discount and delivery to Kansas City. 17/05/2025 15:00
Good day Aiden, in our catalog all prices are given including delivery to the door of the customer. If you buy 3 pieces we will make a discount of 7%. Delivery to Kansas City is included in the price. 17/05/2025 15:04
Waiting for delivery to Jurmala of a TR-02 hard gelatin capsule polishing machine. What about it? 17/05/2025 15:10
Hello Alexander, on your order we inform you that tomorrow until 17:30 the driver will contact you to clarify the time and place of unloading. 17/05/2025 15:13
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 17/05/2025 15:20
Hello Carter, Our manager Natalia tomorrow until 17:30 will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Tournai in 15 days. 17/05/2025 15:22
For shipping to Stockholm do you have to pay anything extra ? 17/05/2025 15:30
Good day Alexander, In our catalog, all prices are inclusive of shipping to the customer's door. Delivery to Stockholm is included. 17/05/2025 15:33
RZW-29 rotary tablet press in York. Regards, Joseph. 17/05/2025 15:40
Joseph, Delivery will be made closer to evening to York . Please have the movers ready. The weight of the equipment is heavy. 17/05/2025 15:42
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled tomorrow until 14:30 to open the box and test. 17/05/2025 15:50
Michael, good afternoon. Great news, please send a photo and video report to WhatsApp +79853643808. 17/05/2025 15:51
Hello, is it possible to buy your blistering machine for tablets and capsules MN-80 1 piece with delivery to Tempe ( Europe) ? How much time for delivery ? 17/05/2025 16:00
William, hello! We have many customers from your city. Delivery to this region is made by EMC. 17/05/2025 16:02
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 17/05/2025 16:10
Hello Gabriel, Our manager Natalia tomorrow until 16:30 will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Stavanger in 15 days. 17/05/2025 16:11
Today we were promised delivery of a blister machine for MN-14 tablets and capsules, remember us ? No one's called us back. 17/05/2025 16:20
Hello Elizabeth, Our manager Natalya in the interval from 10:00-12:00 will dial the driver, also we ask you yourself to the transportation company. 17/05/2025 16:21
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Riga, do you deliver to the terminal or to the actual address? 17/05/2025 16:30
Hello Ellie, we deliver all over USA including to Riga . The price in the catalog includes any delivery our customer asks for. 17/05/2025 16:33
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COATING TABLETS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- BOTTLE FILLING AND CAPPING EQUIPMENT
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS