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Consequently, it is possible to minimize potential side effects without reducing the bioavailability of the drug substance. At the same time, high localized concentrations, as in the case of single-element dosage forms, and therefore irritations in localized areas of the gastrointestinal tract can be avoided.
The main reason for the widespread use of multi-element products is the rapidly increasing popularity of controlled-release oral dosage forms.
Solid dosage forms with controlled release of the drug substance are most often used both to deliver the drug substance to a specific area of the gastrointestinal tract and to maintain the action of the active ingredient for a prolonged period of time.
In the case of microspheres, the above objectives can be achieved by using coating materials (mainly various polymers) that provide the described properties or by creating microspheres with a matrix structure.
Pharmaceutical Glossary
Technical specifications
Regardless of the production method, the microspheres must meet (the following requirements: close to spherical shape and smooth surface. These conditions are essential for further coating in an optimal manner; particle sizes should not vary greatly.
The optimum particle size of microspheres for use in pharmaceutical needs is between 600 and 1000 µm; microspheres should contain the highest possible amount of active ingredient.
In the last twenty years, microspheres have strengthened their position in the pharmaceutical industry due to many reasons. Pellets have high density and abrasion resistance, are well suited for automatic dosing, and their particle size distribution lies within a wide size range.
From a technological point of view, microspheres make the process of creation and production of solid dosage forms more flexible. They are able to flow freely and compact without any difficulties, which determines the homogeneity and reproducibility of the average mass of tablets and capsules.
Additional information
Due to the fact that microspheres have a spherical shape and minimal specific surface area, they are ideal for coating. At the same time, a single dosage form can contain microspheres with different drug substances.
This ability allows two or more active ingredients, chemically compatible or incompatible, absorbed in the same or different parts of the gastrointestinal tract to be combined in the same dosage form.
The same dosage form may contain microspheres having different release rates of the drug substance, which allows the release of the active ingredient to be programmed and controlled and the therapeutic action to be delivered with a greater degree of efficacy.
Pelletized drugs can improve the safety and efficacy of the active ingredient. These multi-element dosage forms, usually presented in the form of suspensions, capsules or disintegrating tablets, have several advantages over single element dosage forms.
Pelletized forms are able to distribute freely in the gastrointestinal tract as single particles, which maximizes absorption and reduces peak changes in plasma drug concentration.
Order status tracking
Good day, delivery time of semi-automatic drum filling machine DF-10 to Cavala, will the courier call us? 28/10/2024 07:30
Violet, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 28/10/2024 07:32
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled as stipulated in the contract to open the box and test. 28/10/2024 07:40
Ava, good afternoon. Great news, please send a photo and video report to WhatsApp +79853643808. 28/10/2024 07:44
Roman, our company bought VL-100 V-shaped powder mixer, but it is not enough for us, can we return it and exchange it for V-300 model? 28/10/2024 07:50
Abigail, good afternoon. When we corresponded with you, I warned you that this is a model with a small load. Unfortunately we can not pick up the equipment. As an option, we will offer our customers with a discount. 28/10/2024 07:51
Remember me? There's a delivery in the Salzburg 28/10/2024 08:00
Abigail, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be after lunch in Salzburg . 28/10/2024 08:04
Waiting for delivery to Cambridge of a TR-02 hard gelatin capsule polishing machine. What about it? 28/10/2024 08:10
Hello Logan, on your order we inform you that in the interval from 10:00-12:00 the driver will contact you to clarify the time and place of unloading. 28/10/2024 08:13
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 28/10/2024 08:20
Good afternoon Zoe, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. as agreed we will get a reply from the manufacturer on the final time frame. 28/10/2024 08:22
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Brussels ? 28/10/2024 08:30
Hello Daniel, Expect in the interval from 14:00-16:00. Once received, please let us know. 28/10/2024 08:34
Dear Roman. Deadline (time) I am waiting for your quotation for a machine for removing tablets and capsules from blister packs MB-10 with delivery. 28/10/2024 08:40
Hello Ava, By the specified time we will send the offer to your e-mail. Now we are waiting for an answer from the transportation company on the delivery time to Nashville . 28/10/2024 08:42
Waiting for delivery to Leicester of a TR-02 hard gelatin capsule polishing machine. What about it? 28/10/2024 08:50
Hello Evelyn, on your order we inform you that tomorrow until 14:30 the driver will contact you to clarify the time and place of unloading. 28/10/2024 08:51
Good afternoon, I am hoping as agreed to get the UNIC 600A Tablet Press in Bonifacio ! Please comment. 28/10/2024 09:00
Good day, Elijah! Our manager has communicated with the delivery service, the equipment will be delivered to Bonifacio at your address. Please let us know when you receive it. 28/10/2024 09:02
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING