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Microspheres and pellets technology basics

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Microspheres and pellets technology basics

Microspheres (pellets) are a new type of solid dosage form.
Recently, in the pharmaceutical industry, drug manufacturers are engaged in the production of microspheres, or pellets (from English pellet – ball, pellet, pellet), as a final or intermediate type of dosage form for the production of finished dosage forms.
Microspheres are increasingly used in the production of finished pharmaceuticals, as they have a number of significant and undeniable advantages.
Pellets can be tableted with the addition of suitable excipients, they can be the contents of capsules, as well as part of suspensions.
Microspheres (pellets) are agglomerates of finely dispersed powders or granules, which in turn may comprise drug and excipients. Microspheres are small, spherical or hemispherical shaped solid particles with a diameter of 0.5 to 1.5 mm, having good friability, intended for oral administration.
Microspheres can be manufactured by various methods, but the most widely used methods are compacting and depositing the drug substance onto inert microspheres.

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  • Information updated : 10 / 04 / 2025
  • In stock
  • Manufacturer : 1 year for Microspheres and pellets technology basics

Model: Microspheres and pellets

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Consequently, it is possible to minimize potential side effects without reducing the bioavailability of the drug substance. At the same time, high localized concentrations, as in the case of single-element dosage forms, and therefore irritations in localized areas of the gastrointestinal tract can be avoided.
The main reason for the widespread use of multi-element products is the rapidly increasing popularity of controlled-release oral dosage forms.
Solid dosage forms with controlled release of the drug substance are most often used both to deliver the drug substance to a specific area of the gastrointestinal tract and to maintain the action of the active ingredient for a prolonged period of time.
In the case of microspheres, the above objectives can be achieved by using coating materials (mainly various polymers) that provide the described properties or by creating microspheres with a matrix structure.

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Technical specifications

Regardless of the production method, the microspheres must meet (the following requirements: close to spherical shape and smooth surface. These conditions are essential for further coating in an optimal manner; particle sizes should not vary greatly.
The optimum particle size of microspheres for use in pharmaceutical needs is between 600 and 1000 µm; microspheres should contain the highest possible amount of active ingredient.
In the last twenty years, microspheres have strengthened their position in the pharmaceutical industry due to many reasons. Pellets have high density and abrasion resistance, are well suited for automatic dosing, and their particle size distribution lies within a wide size range.
From a technological point of view, microspheres make the process of creation and production of solid dosage forms more flexible. They are able to flow freely and compact without any difficulties, which determines the homogeneity and reproducibility of the average mass of tablets and capsules.

Additional information

Due to the fact that microspheres have a spherical shape and minimal specific surface area, they are ideal for coating. At the same time, a single dosage form can contain microspheres with different drug substances.
This ability allows two or more active ingredients, chemically compatible or incompatible, absorbed in the same or different parts of the gastrointestinal tract to be combined in the same dosage form.
The same dosage form may contain microspheres having different release rates of the drug substance, which allows the release of the active ingredient to be programmed and controlled and the therapeutic action to be delivered with a greater degree of efficacy.
Pelletized drugs can improve the safety and efficacy of the active ingredient. These multi-element dosage forms, usually presented in the form of suspensions, capsules or disintegrating tablets, have several advantages over single element dosage forms.
Pelletized forms are able to distribute freely in the gastrointestinal tract as single particles, which maximizes absorption and reduces peak changes in plasma drug concentration.

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