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Insoluble coatings include ethylcellulose, surfactants, etc. These coatings are created with the help of some cellulose derivatives, which are applied to the tablet in the form of solutions. To increase the strength and elasticity of the coatings, plasticizers are introduced into their composition. The mechanism of drug release from tablets with insoluble shells is that digestive juices can quickly penetrate through the pores of the shell and dissolve the active substance of the tablet or cause its swelling. In the first case, the dissolved substance diffuses through the film in the opposite direction – towards the gastrointestinal tract under the influence of the concentration difference, in the second case – there is a rupture of the shell by increasing the volume of the tablet, after which the drug is released in the usual way. Uniform release of the drug substance through the intact shell occurs regardless of the composition, enzyme action and pH value of the environment in the gastrointestinal tract. It depends only on the solubility and pore size of the shell, which can be modified as required. Therefore, it is possible to produce tablets with a pre-calculated rate of drug release.
Pharmaceutical Glossary
Technical specifications
Water-soluble coatings improve the appearance of tablets, correct their taste and odor, protect from mechanical damage, but do not protect from air moisture. Water-soluble coatings are formed by PVP, MC, Na CMC, etc., applied to tablets in the form of water-ethanol or aqueous solutions. Coatings soluble in gastric juice – films protecting from moisture, provide rapid dissolution in the stomach (within 10-30 min). The film-formers of this group include polymers having amino groups in the molecule – diethylaminomethylcellulose, para-aminotenzoates of sugars and acetyl-cellulose. Coating of tablets is carried out by solutions of the above substances in organic solvents – ethanol or isopropanol, which are volatilized during coating and drying. Intestine-soluble coatings protect the drug substance contained in the tablet from the acid reaction of gastric juice, protect the gastric mucosa from the irritating effect of some drugs, localize the drug substance in the intestine, prolonging to a certain extent its effect, and also have a pronounced moisture-protective effect. The process of dissolution of shells in the body is due to the effect on them a complex of enzymes to various solubilizing substances contained in the intestinal juice.
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Additional information
High molecular weight compounds are used as film formers for intestine-soluble coatings. They dissociate in neutral and alkaline media to form insoluble salts. Both natural substances are used: shellac, casein, keratin, paraffin, ceresin, cetyl alcohol, and synthetic products: stearic acid in combination of fats with bile acids, butyl stearate, acetylphthalyl cellulose, poly-vinyl acetateflatate, polyacrylic resins (Eudragid). The listed film formers are applied to tablets in the form of solutions. Pigments and dyes are added to the solutions to obtain colored shells. By varying different polymers and different film thicknesses, it is possible to achieve disintegration of the tablet in a certain part of the intestinal tract. Intestine-soluble coatings can withstand the effects of gastric juice for 2-4 h or more, which allows such dosage forms to pass through the stomach unchanged; in the intestinal juice they disintegrate within 1 h, ensuring the release of the drug in the intestine. Insoluble coatings are films with a microporous structure for controlled release of the drug substance. The main purpose of this type of coatings is to protect tablets, pellets or granules from mechanical damage and atmospheric moisture, to eliminate unpleasant odor and taste of the medicinal substance, prolonging its effect.
Order status tracking
Contract #12, the deadline for delivery has already passed. Take action at last. Accelerate Tsibulsky R.G. 03/07/2024 01:38
Hello Lucas, we are on vacation on weekends and are not able to respond to messages. Raise the contract, delivery time of equipment to your warehouse in Amsterdam to 50 working ( not calendar) days. Action taken. 03/07/2024 01:39
Can your technician come to Helsinki? We need technologist consultation and assistance. 03/07/2024 01:48
Ethan, We have already received your email. A technician in the morning will contact you. Don't worry. 03/07/2024 01:50
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in Stockton 03/07/2024 01:58
Hello Joseph, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 03/07/2024 02:00
We have sent to info@minipress.ru photos of the damaged box with induction welding membrane machine FG-08. Please call back. 03/07/2024 02:08
Good day, Grace! Damage to the packaging is unfortunately a common practice in transportation. Please carefully unpack the shipment and send us a series of photos. We will take a look and take action. 03/07/2024 02:08
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 03/07/2024 02:18
Mason, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer tomorrow until 17:30. We will report back immediately. 03/07/2024 02:19
Mixer with paddle for powders CX-100 what is the exact packing size ? 03/07/2024 02:28
Grace, Hello! Packing dimensions 1200x640x1000 mm, packing weight 250 kg. Please let me know when you receive the shipment. 03/07/2024 02:31
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to New Orleans. Thank you. 03/07/2024 02:38
Michael, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to New Orleans is scheduled for between 12:00-14:00. Please notify us upon receipt. 03/07/2024 02:38
Today we were promised delivery of a blister machine for MN-14 tablets and capsules, remember us ? No one's called us back. 03/07/2024 02:48
Hello Avery, Our manager Natalya tomorrow until 12:30 will dial the driver, also we ask you yourself to the transportation company. 03/07/2024 02:51
PU-420 flow-pack packaging machine along with 500 kg packaging , delivery to Jacksonville. Please confirm the delivery time. 03/07/2024 02:58
Good afternoon Samuel, your shipment has left. Arrival time between 16:00-18:00. The driver will call you back later. Please organize prompt unloading. 03/07/2024 02:59
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Dublin, do you deliver to the terminal or to the actual address? 03/07/2024 03:08
Hello Aiden, we deliver all over USA including to Dublin . The price in the catalog includes any delivery our customer asks for. 03/07/2024 03:10
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR COATING TABLETS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES