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Delivery of the active substance to any part of the GI tract is achieved by using as a coating exactly those types of Eudragit polymers that dissolve at certain acidity (pH) values of the environment peculiar to this or that part of the GI tract. It is also possible to use combinations of separate types of polymers when it is necessary to deliver drugs to a strictly defined part of the GI tract. The described feature of Eudragit films is crucial for more effective treatment of a number of diseases, including ulcerative colitis, Crohn’s disease and even some cancers. The intestinal soluble coating (water-based) is Kollicoat MAE 30DP (methacrylic acid + ethyl acrylate 1+1) polymer as a 30% water-soluble dispersion and Kollicoat MAE 100P polymer as a 100% water-dispersible powder. Kollicoat is the patented name for all BASF coatings. Kollicoat MAE 1 OOP is a powder consisting mainly of methacrylic acid-ethyl acrylate copolymer (1:1). It has an average molecular weight of approximately 250,000 kDa. It is prepared from Kollicoat MAE*30DP by neutralizing up to about 6 mol% of the copolymer with sodium hydroxide. Additionally, this powder includes two stabilizers to prevent sedimentation and degradation of the copolymer. These polymers form non-hygroscopic films, which require a plasticizer to give the product the necessary elasticity, as the film is quite brittle. Kollicoat MAE films are completely insoluble in acidic media (e.g. 0.1 M HC1 or gastric juice). However, at pH values >5.5 they dissolve at an increasing rate. Therefore, these films are optimally suited for enteric-coated tablets that dissolve after passing through the stomach.
Pharmaceutical Glossary
Technical specifications
Intestine-soluble coatings are used for dosage forms that, when administered, are expected to delay the release of drugs, may be destroyed in the stomach (e.g., pancreatin, erythromycin), may cause nausea or bleeding, or may cause irritation of the gastric mucosa (e.g., aspirin, steroids). Such coatings can be used to re-release drugs in different parts of the GI tract. The action of intestine-soluble coating is due to the difference in properties of gastric and intestinal media due to different acidity and enzyme composition. Although some time ago there were attempts to create coatings that degrade under the action of intestinal enzymes, these developments were not popular, because enzymatic degradation of the film is a rather long process. Thus, most of the widely used intestine-soluble coatings are weak acids that do not dissociate at low pH values, but are easily ionized when the pH of the medium is increased to 5. The most effective enteric soluble polymers are polyacids. Enzyme-degradable coatings are currently used as protective coatings for delivery of polypeptide drug substances into the colon. One of the first synthetic polymers used for intestine-degradable coatings is phthalate cellulose acetate (PCA). However, pH>6 is required for dissolution of the coating, which significantly delays drug release. This polymer is relatively permeable to moisture and gastric juice compared to most enteric soluble polymers. In addition, it is highly susceptible to hydrolytic degradation, in which phthalic acid separates from acetic acid, leading to changes in the properties of the polymer and hence the action of the enteric coating.
Additional information
Other useful polymers used in enteric coating formulations include: Polyvinyl acetate phthalate (PVAP), which is less permeable to moisture and gastric juice, more resistant to hydrolysis, and able to ionize at low pH values; hydroxypropyl methylcellulose phthalate (HPMCP), which has properties similar to those of PVAP; acrylic polymers such as methacrylic acid or methacrylic acid ester copolymer (some of which have a high dissociation constant); cellulose acetate trimellitate (ATC), which has properties similar to those of AFC; carboxymethyl ethyl cellulose (CMEC); hydroxypropyl methylcellulose acetate succinate (HPMCS).
In recent years, acrylic copolymers have been considered most suitable for the development of enteric coatings. A new type of film coatings has emerged, based on poly-methyl methacrylates (PMMA), polymers derived from acrylic acid, called Eudragit, which have the following properties: Excellent moisture-, heat- and light-protective properties, hence increasing the shelf life of drugs (far exceeding the corresponding properties of cellulose); complete neutralization of unpleasant taste and odor, which are often possessed by the active ingredients in the tablet; ease of swallowing large-sized tablets due to the sliding properties of the films; uniformly colored tablets of any shade when combined with pigments; delivery of the active ingredient to any part of the GI tract; use of Eudragit as a matrix for dosage forms with retarded
Order status tracking
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 22/07/2024 06:23
Hello Carter, Our manager Natalia tomorrow until 16:30 will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Pilsen in 15 days. 22/07/2024 06:26
In Cavala ITA-01 tablet and capsule counter, RZ-9 rotary tablet press and manual capsule filling machine. Help when we get it ? 22/07/2024 06:33
Good afternoon, Jackson! We have received from the factories photos of the equipment after packing. Natalia will forward the photos to you. Delivery time to you is 45-50 days. 22/07/2024 06:37
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to Miami. Thank you. 22/07/2024 06:43
Scarlett, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to Miami is scheduled for after lunch. Please notify us upon receipt. 22/07/2024 06:46
Remember me? There's a delivery in the Salzburg 22/07/2024 06:53
Sofia, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be tomorrow until 15:30 in Salzburg . 22/07/2024 06:56
Mixer with paddle for powders CX-100 what is the exact packing size ? 22/07/2024 07:03
Layla, Hello! Packing dimensions 1200x640x1000 mm, packing weight 250 kg. Please let me know when you receive the shipment. 22/07/2024 07:06
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 22/07/2024 07:13
Hello Samuel, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 22/07/2024 07:16
Remember me? There's a delivery in the Luzern 22/07/2024 07:23
Nova, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be tomorrow until 14:30 in Luzern . 22/07/2024 07:25
Hello, is it possible to buy your blistering machine for tablets and capsules MN-80 1 piece with delivery to Virginia Beach ( Europe) ? How much time for delivery ? 22/07/2024 07:33
Alexander, hello! We have many customers from your city. Delivery to this region is made by EMC. 22/07/2024 07:37
I would like to discuss the purchase of model FK-05 - capping and screw cap machine. 22/07/2024 07:43
Good day. You can call on tel. +79853643808 or to the mail specified on the site. Elijah, this chat is only for tracking shipments. 22/07/2024 07:46
The MZ-10 expiration date and date handheld printer has still not been delivered. The driver did not answer and dropped calls yesterday. 22/07/2024 07:53
Hello Daniel, Transportation has advised that In the afternoon driver will definitely deliver the box to your address. We apologize. 22/07/2024 07:55
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- PERISTALTIC PUMPS DISPENSERS