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Dry granulation of powders

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EQUIPMENT CATALOG NOVELTIES :

Dry granulation of powders

Dry granulation is a method in which powdered material (mixture of drug and excipients) is subjected to compaction to obtain granulate. Dry granulation is used when wet granulation affects the stability and/or physicochemical characteristics of the drug substance, and when the drug and excipients do not compress well after the wet granulation process.
If drug substances undergo physical changes (melting, softening, color change) or chemical reactions during drying, they are briquetted, i.e. briquettes are pressed from the powder on special briquetting presses with large-sized dies (25×25 mm) under high pressure.

Whatever your task, MINIPRESS is ready to take it on. We are more powerful than many competitors and our service is much more convenient. We offer our customers impressive terms and amazingly fast turnaround times. Our specialists use the most advanced technologies in the world to select various equipment. We have everything you need for modern production of any level. And even more.

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  • Information updated : 09 / 12 / 2024
  • In stock
  • Manufacturer : 1 year for Dry granulation of powders

Model: Dry granulation of powders

Expert Services Index

  1. Step-by-step assessment of your task by experts and a detailed discussion of solution options within 24 hours.
  2. Company selection manufacturer and negotiations with selected provider.
  3. Selection, optimal for the client, payment scheme and delivery time.
  4. Assume responsibility and risks for delivery, insurance and customs cargo clearance in USA. Further transit to countries.
  5. Receiving and checking equipmentbefore sending with a video report.
  6. On arrival in USA delivery of equipment to your door.
  7. Consultation from our specialist with 20 years of experience throughout the life of the equipment.
  8. Export to any world countries. Air, sea and road transport with the necessary documents.
  9. Equipment on lease with an advance payment of 10%. Convenient payment schedule. No limit. Approval for three documents: passport, lease agreement and extract. We cooperate with leasing companies.

If you did not find the equipment you need in our catalog, then call +79853643808 or make a request in the tab “Request a Call” and we will definitely offer you what you were looking for, or we will select similar equipment that will suit not only the technical characteristics, but also the price.
Guaranteed up to 15% discount on our services when subsequent purchase in the pharmaceutical equipment catalog.
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In the second step, the agglomeration process takes place due to the formation of solid bridges as a result of sintering of particles, partial melting or crystallization of soluble substances. Next, solid bridges are formed between the particles through chemical reaction, solidification of binders or crystallization of insoluble substances. The dry granulation process is carried out on special equipment. The combined plant combines the processes of compacting, crushing and separating the resulting granules. The principle of operation of the press-granulator is as follows: rotating in different directions, the rollers grasp the powdery mixture and press it through the holes in the wall of the hollow rollers. Inside the hollow rollers, a knife cuts the resulting pellets.

Pharmaceutical Glossary

Articles  — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.
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Technical specifications

The resulting briquettes are crushed using mills, fractionated using sieves and pressed on tablet machines into tablets of a given weight and diameter. It should be noted that dry granulation is used less frequently in tablet manufacturing than wet granulation or direct pressing. The main stages of the dry granulation process are: powder mixing; compacting; grinding; sieving; powdering; blending. Some stages may be omitted. Granulation by briquetting can also be used when the LV has good compressibility and does not require additional particle binding by binders. The number of prescriptions recommending the use of dry binder additives followed by direct pressing has increased significantly.

Additional information

The most well-known method of dry granulation is the compacting method, which compacts dry powder, giving it the shape of granules under some pressure. Nowadays, using the method of dry granulation, dry binders (e.g. microcrystalline cellulose, polyethylene oxide) are introduced into the composition of the tablet mass, providing under pressure the adhesion of both hydrophilic and hydrophobic particles. The bonding of particles to each other occurs under the influence of forces of different nature. At the first stage molecular, electrostatic, magnetic forces act. Then the formation of bonds between particles takes place, after which capillary forces begin to act.

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Minipress Company

Roman Tsibulsky pharmaceutical equipment supplier www.Minipress.ru

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The company has a high reputation of a reliable partner. Experience in supplying equipment for pharmaceutical business since 1999.

Roman Tsibulsky

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