СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / GRANULATION PROCESS IN TABLET PRODUCTION / Dry granulation of powders

Dry granulation of powders

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / GRANULATION PROCESS IN TABLET PRODUCTION / Dry granulation of powders

Dry granulation of powders

Dry granulation is a method in which powdered material (mixture of drug and excipients) is subjected to compaction to obtain granulate. Dry granulation is used when wet granulation affects the stability and/or physicochemical characteristics of the drug substance, and when the drug and excipients do not compress well after the wet granulation process.
If drug substances undergo physical changes (melting, softening, color change) or chemical reactions during drying, they are briquetted, i.e. briquettes are pressed from the powder on special briquetting presses with large-sized dies (25×25 mm) under high pressure.

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Information updated : 09 / 12 / 2025
In stock
Manufacturer : 1 year for Dry granulation of powders

Model: Dry granulation of powders

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Equipment on lease with an advance payment of 10%. Convenient payment schedule. No limit. Approval for three documents: passport, lease agreement and extract. We cooperate with leasing companies.

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In the second step, the agglomeration process takes place due to the formation of solid bridges as a result of sintering of particles, partial melting or crystallization of soluble substances. Next, solid bridges are formed between the particles through chemical reaction, solidification of binders or crystallization of insoluble substances. The dry granulation process is carried out on special equipment. The combined plant combines the processes of compacting, crushing and separating the resulting granules. The principle of operation of the press-granulator is as follows: rotating in different directions, the rollers grasp the powdery mixture and press it through the holes in the wall of the hollow rollers. Inside the hollow rollers, a knife cuts the resulting pellets.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

The resulting briquettes are crushed using mills, fractionated using sieves and pressed on tablet machines into tablets of a given weight and diameter. It should be noted that dry granulation is used less frequently in tablet manufacturing than wet granulation or direct pressing. The main stages of the dry granulation process are: powder mixing; compacting; grinding; sieving; powdering; blending. Some stages may be omitted. Granulation by briquetting can also be used when the LV has good compressibility and does not require additional particle binding by binders. The number of prescriptions recommending the use of dry binder additives followed by direct pressing has increased significantly.

Additional information

The most well-known method of dry granulation is the compacting method, which compacts dry powder, giving it the shape of granules under some pressure. Nowadays, using the method of dry granulation, dry binders (e.g. microcrystalline cellulose, polyethylene oxide) are introduced into the composition of the tablet mass, providing under pressure the adhesion of both hydrophilic and hydrophobic particles. The bonding of particles to each other occurs under the influence of forces of different nature. At the first stage molecular, electrostatic, magnetic forces act. Then the formation of bonds between particles takes place, after which capillary forces begin to act.

Order status tracking

Roman Tsibulsky +79853643808 now online

Alexander
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 22/12/2025 20:58

Roman Tsibulsky
Good afternoon Alexander, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. tomorrow until 14:30 we will get a reply from the manufacturer on the final time frame. 22/12/2025 21:02

Benjamin
To what address to send you samples of bottles and caps to send them to the factory ? Regards Benjamin. 22/12/2025 21:08

Roman Tsibulsky
Good day, Benjamin We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 22/12/2025 21:10

David
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 22/12/2025 21:18

Roman Tsibulsky
David, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer tomorrow until 17:30. We will report back immediately. 22/12/2025 21:22

Joseph
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to Milwaukee. Thank you. 22/12/2025 21:28

Roman Tsibulsky
Joseph, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to Milwaukee is scheduled for in the morning. Please notify us upon receipt. 22/12/2025 21:30

Emilia
PU-250 flow-pack packaging machine, please advise delivery status. 22/12/2025 21:38

Roman Tsibulsky
Hello Emilia, your equipment is undergoing customs clearance. Your manager Natalia will contact you as agreed 22/12/2025 21:40

Lucas
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled in the interval from 14:00-16:00 to open the box and test. 22/12/2025 21:48

Roman Tsibulsky
Lucas, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 22/12/2025 21:49

Abigail
LW-35 automatic PVC+cardboard blister packaging machine has been on the road for 30 days. What news ? 22/12/2025 21:58

Roman Tsibulsky
Hello Abigail, We are on time, before lunch a driver will contact you about unloading. 22/12/2025 22:01

Liam
Tell me the NJ-120 automatic capsule machine went ? 22/12/2025 22:08

Roman Tsibulsky
Liam, good afternoon. Yes, already tomorrow by lunchtime you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 22/12/2025 22:10

Violet
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 22/12/2025 22:18

Roman Tsibulsky
Violet, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Oklahoma City ? Contact Natalia, she will send the contract and invoice. 22/12/2025 22:21

Samuel
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Frankfurt, do you deliver to the terminal or to the actual address? 22/12/2025 22:28

Roman Tsibulsky
Hello Samuel, we ship all over Europe and the US including to Frankfurt . The price in the catalog includes any delivery our customer asks for. 22/12/2025 22:30