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In the second step, the agglomeration process takes place due to the formation of solid bridges as a result of sintering of particles, partial melting or crystallization of soluble substances. Next, solid bridges are formed between the particles through chemical reaction, solidification of binders or crystallization of insoluble substances. The dry granulation process is carried out on special equipment. The combined plant combines the processes of compacting, crushing and separating the resulting granules. The principle of operation of the press-granulator is as follows: rotating in different directions, the rollers grasp the powdery mixture and press it through the holes in the wall of the hollow rollers. Inside the hollow rollers, a knife cuts the resulting pellets.
Pharmaceutical Glossary
Technical specifications
The resulting briquettes are crushed using mills, fractionated using sieves and pressed on tablet machines into tablets of a given weight and diameter. It should be noted that dry granulation is used less frequently in tablet manufacturing than wet granulation or direct pressing. The main stages of the dry granulation process are: powder mixing; compacting; grinding; sieving; powdering; blending. Some stages may be omitted. Granulation by briquetting can also be used when the LV has good compressibility and does not require additional particle binding by binders. The number of prescriptions recommending the use of dry binder additives followed by direct pressing has increased significantly.
Additional information
The most well-known method of dry granulation is the compacting method, which compacts dry powder, giving it the shape of granules under some pressure. Nowadays, using the method of dry granulation, dry binders (e.g. microcrystalline cellulose, polyethylene oxide) are introduced into the composition of the tablet mass, providing under pressure the adhesion of both hydrophilic and hydrophobic particles. The bonding of particles to each other occurs under the influence of forces of different nature. At the first stage molecular, electrostatic, magnetic forces act. Then the formation of bonds between particles takes place, after which capillary forces begin to act.
Order status tracking
Roman Tsibulsky +79853643808
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Ruby
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in New Orleans 22/02/2025 06:23
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in New Orleans 22/02/2025 06:23
Roman Tsibulsky
Hello Ruby, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 22/02/2025 06:25
Hello Ruby, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 22/02/2025 06:25
Hazel
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Nice ? 22/02/2025 06:33
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Nice ? 22/02/2025 06:33
Roman Tsibulsky
Hello Hazel, Expect tomorrow until 13:30. Once received, please let us know. 22/02/2025 06:35
Hello Hazel, Expect tomorrow until 13:30. Once received, please let us know. 22/02/2025 06:35
Michael
In Butrint ITA-01 tablet and capsule counter, RZ-9 rotary tablet press and manual capsule filling machine. Help when we get it ? 22/02/2025 06:43
In Butrint ITA-01 tablet and capsule counter, RZ-9 rotary tablet press and manual capsule filling machine. Help when we get it ? 22/02/2025 06:43
Roman Tsibulsky
Good afternoon, Michael! We have received from the factories photos of the equipment after packing. Natalia will forward the photos to you. Delivery time to you is 45-50 days. 22/02/2025 06:46
Good afternoon, Michael! We have received from the factories photos of the equipment after packing. Natalia will forward the photos to you. Delivery time to you is 45-50 days. 22/02/2025 06:46
Aurora
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Luzern, then I want to buy an automatic capsule machine model GN-28 22/02/2025 06:53
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Luzern, then I want to buy an automatic capsule machine model GN-28 22/02/2025 06:53
Roman Tsibulsky
Good afternoon, Aurora! On the first question - the shipment will arrive in Luzern after lunch. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 22/02/2025 06:56
Good afternoon, Aurora! On the first question - the shipment will arrive in Luzern after lunch. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 22/02/2025 06:56
Mia
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Lisbon ? 22/02/2025 07:03
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Lisbon ? 22/02/2025 07:03
Roman Tsibulsky
Hello Mia, Expect tomorrow until 17:30. Once received, please let us know. 22/02/2025 07:04
Hello Mia, Expect tomorrow until 17:30. Once received, please let us know. 22/02/2025 07:04
William
Remember me? There's a delivery in the Prague 22/02/2025 07:13
Remember me? There's a delivery in the Prague 22/02/2025 07:13
Roman Tsibulsky
William, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be as stipulated in the contract in Prague . 22/02/2025 07:16
William, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be as stipulated in the contract in Prague . 22/02/2025 07:16
Alexander
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Munich, then I want to buy an automatic capsule machine model GN-28 22/02/2025 07:23
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Munich, then I want to buy an automatic capsule machine model GN-28 22/02/2025 07:23
Roman Tsibulsky
Good afternoon, Alexander! On the first question - the shipment will arrive in Munich as agreed. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 22/02/2025 07:26
Good afternoon, Alexander! On the first question - the shipment will arrive in Munich as agreed. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 22/02/2025 07:26
William
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 22/02/2025 07:33
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 22/02/2025 07:33
Roman Tsibulsky
William, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer between 16:00-18:00. We will report back immediately. 22/02/2025 07:37
William, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer between 16:00-18:00. We will report back immediately. 22/02/2025 07:37
Emma
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 22/02/2025 07:43
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 22/02/2025 07:43
Roman Tsibulsky
Hello Emma, Our manager Natalia tomorrow until 16:30 will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Constance in 15 days. 22/02/2025 07:45
Hello Emma, Our manager Natalia tomorrow until 16:30 will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Constance in 15 days. 22/02/2025 07:45
Daniel
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to London, do you deliver to the terminal or to the actual address? 22/02/2025 07:53
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to London, do you deliver to the terminal or to the actual address? 22/02/2025 07:53
Roman Tsibulsky
Hello Daniel, we ship all over Europe and the US including to London . The price in the catalog includes any delivery our customer asks for. 22/02/2025 07:55
Hello Daniel, we ship all over Europe and the US including to London . The price in the catalog includes any delivery our customer asks for. 22/02/2025 07:55
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- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COATING TABLETS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS