СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / GRANULATION PROCESS IN TABLET PRODUCTION / Binders for wet granulation

Binders for wet granulation

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / GRANULATION PROCESS IN TABLET PRODUCTION / Binders for wet granulation

Binders for wet granulation

There are some requirements for the granulating liquid, one of them is that the granulating liquid must not dissolve the active ingredient. Water, aqueous ethanol solution, acetone and methylene chloride can be used as granulating liquid. A wide range of substances are used as binders for wet granulation in modern pharmaceutical production, for example: starch (5-15 % g/g), starch derivatives, cellulose derivatives, which improve the plasticity of granules, as well as gelatin (1-3 % g/g) and PVP (3-10 % g/g). The most common and effective wet granulation binder in the modern pharmaceutical industry is a synthetic polymer such as Collidon (PVP), the various grades of which (Collidon 25, 30 and 90F) are widely available on the market.

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Information updated : 10 / 01 / 2026
In stock
Manufacturer : 1 year for Binders for wet granulation

Model: Wet granulation

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Equipment leasing with advance payment from 10%

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Our service and customer service

Plasdon polymers have excellent bonding ability, good film forming properties, surfactant properties and high solubility in water and many solvents used in pharmaceutical applications. Due to this combination of properties, these polymers are widely used in a number of pharmaceuticals. Plasdone polymers have long been used as binding agents in wet granulation. Plasdone®S-630 Copovidone is a synthetic 60:40 linear polymer of N-vinyl-2 pyrrolidone and vinyl acetate. With its unique properties, Plasdone S-630 is well suited as a tablet binder for direct pressing and dry granulation applications, as well as a wet granulation binder.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

The granules obtained with PVP are hard, easy to bulk, forming harder tablets with low brittleness. PVP polymer improves the solubility of the active ingredient by forming complexes. In addition, PVP acts as a crystallization inhibitor. The regularities presented below were identified by BASF’s fine chemistry department. They are discussed using Collidon as an example. Wet granulation using Collidon 25, Collidon 30 and Collidon 90F generally results in a harder granular material with better bulk properties than other binders – less abrasion and higher bond strength. The polymer content of the granulating fluid used can vary from Collidon 25 – 2-5%; Collidon 30 – 2-5%; Collidon 90F – 1-3%.

Additional information

Thus, BASF’s research showed that Collidon 90F produced the highest tablet hardness at the same pressing pressure. All binders were used in the amount of 3%. Based on the data presented, it can be concluded that the increased hardness and reduced brittleness of calcium phosphate tablets when Collidon 30 is used as a binder in the wet granulation process. In addition to Collidon, there are a large number of substances used as binders in the pharmaceutical industry. Let us consider two of them. PlasdonPPovidone is a series of synthetic water-soluble homopolymers of N-vinyl-2 pyrrolidone.

Order status tracking

Roman Tsibulsky +79853643808 now online

Joseph
Please inform me about the status of the order Rotary tablet press RZ-10A in Arlington ? 29/01/2026 22:34

Roman Tsibulsky
Good afternoon, Joseph. We have contacted the carrier, delivery is scheduled in the interval from 10:00-12:00. Please let us know when you receive it. Thank you. 29/01/2026 22:34

Mila
Good day, tell me need delivery in Chicago to the settlement in the distance of 20 km. Can you organize this? 29/01/2026 22:44

Roman Tsibulsky
Mila, Good afternoon, please send us an email to info@minipress.ru with the exact name of the equipment model, city, and your coordinates. We will calculate the delivery to you. 29/01/2026 22:48

Victoria
I've been calling your office since this morning, and no one's picking up the phone. 29/01/2026 22:54

Roman Tsibulsky
Good afternoon, Victoria! The office will be open from 9:00 GMT. We'll be in touch. 29/01/2026 22:55

Henry
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 29/01/2026 23:04

Roman Tsibulsky
Hello Henry, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 29/01/2026 23:06

Maya
You have to pay for delivery to Lyme over and above the delivery amount in the contract ? 29/01/2026 23:14

Roman Tsibulsky
Maya, The catalog shows the price with door delivery. The unloading of the equipment, upon receipt of the shipment, will be charged to you separately. 29/01/2026 23:18

Alexander
Roman, our company bought VL-100 V-shaped powder mixer, but it is not enough for us, can we return it and exchange it for V-300 model? 29/01/2026 23:24

Roman Tsibulsky
Alexander, good afternoon. When we corresponded with you, I warned you that this is a model with a small load. Unfortunately we can not pick up the equipment. As an option, we will offer our customers with a discount. 29/01/2026 23:25

Lucas
The MZ-10 expiration date and date handheld printer has still not been delivered. The driver did not answer and dropped calls yesterday. 29/01/2026 23:34

Roman Tsibulsky
Hello Lucas, Transportation has advised that closer to evening driver will definitely deliver the box to your address. We apologize. 29/01/2026 23:36

Muhammad
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 29/01/2026 23:44

Roman Tsibulsky
Muhammad, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Philadelphia ? Contact Natalia, she will send the contract and invoice. 29/01/2026 23:47

Joseph
Good day, I want before lunch to get FF-02 tablet and capsule filling machine in Tbilisi? 29/01/2026 23:54

Roman Tsibulsky
Good afternoon, Joseph! We have contacted the transportation company, your shipment is arriving in Tbilisi without delay. Please wait for a call from a representative of Business Lines. 29/01/2026 23:57

Sophia
You have to pay for delivery to Cambridge over and above the delivery amount in the contract ? 30/01/2026 00:04

Roman Tsibulsky
Sophia, The catalog shows the price with door delivery. The unloading of the equipment, upon receipt of the shipment, will be charged to you separately. 30/01/2026 00:07