СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / GRANULATION PROCESS IN TABLET PRODUCTION / Binders for wet granulation

Binders for wet granulation

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / GRANULATION PROCESS IN TABLET PRODUCTION / Binders for wet granulation

Binders for wet granulation

There are some requirements for the granulating liquid, one of them is that the granulating liquid must not dissolve the active ingredient. Water, aqueous ethanol solution, acetone and methylene chloride can be used as granulating liquid. A wide range of substances are used as binders for wet granulation in modern pharmaceutical production, for example: starch (5-15 % g/g), starch derivatives, cellulose derivatives, which improve the plasticity of granules, as well as gelatin (1-3 % g/g) and PVP (3-10 % g/g). The most common and effective wet granulation binder in the modern pharmaceutical industry is a synthetic polymer such as Collidon (PVP), the various grades of which (Collidon 25, 30 and 90F) are widely available on the market.

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Information updated : 11 / 12 / 2025
In stock
Manufacturer : 1 year for Binders for wet granulation

Model: Wet granulation

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Our service and customer service

Plasdon polymers have excellent bonding ability, good film forming properties, surfactant properties and high solubility in water and many solvents used in pharmaceutical applications. Due to this combination of properties, these polymers are widely used in a number of pharmaceuticals. Plasdone polymers have long been used as binding agents in wet granulation. Plasdone®S-630 Copovidone is a synthetic 60:40 linear polymer of N-vinyl-2 pyrrolidone and vinyl acetate. With its unique properties, Plasdone S-630 is well suited as a tablet binder for direct pressing and dry granulation applications, as well as a wet granulation binder.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

The granules obtained with PVP are hard, easy to bulk, forming harder tablets with low brittleness. PVP polymer improves the solubility of the active ingredient by forming complexes. In addition, PVP acts as a crystallization inhibitor. The regularities presented below were identified by BASF’s fine chemistry department. They are discussed using Collidon as an example. Wet granulation using Collidon 25, Collidon 30 and Collidon 90F generally results in a harder granular material with better bulk properties than other binders – less abrasion and higher bond strength. The polymer content of the granulating fluid used can vary from Collidon 25 – 2-5%; Collidon 30 – 2-5%; Collidon 90F – 1-3%.

Additional information

Thus, BASF’s research showed that Collidon 90F produced the highest tablet hardness at the same pressing pressure. All binders were used in the amount of 3%. Based on the data presented, it can be concluded that the increased hardness and reduced brittleness of calcium phosphate tablets when Collidon 30 is used as a binder in the wet granulation process. In addition to Collidon, there are a large number of substances used as binders in the pharmaceutical industry. Let us consider two of them. PlasdonPPovidone is a series of synthetic water-soluble homopolymers of N-vinyl-2 pyrrolidone.

Order status tracking

Roman Tsibulsky +79853643808 now online

Savannah
To what address to send you samples of bottles and caps to send them to the factory ? Regards Savannah. 30/12/2025 14:33

Roman Tsibulsky
Good day, Savannah We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 30/12/2025 14:34

Ava
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in Phoenix 30/12/2025 14:43

Roman Tsibulsky
Hello Ava, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 30/12/2025 14:44

Alexander
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Gerona. 30/12/2025 14:53

Roman Tsibulsky
Hello Alexander, Delivery status checked, in the morning is arriving at Gerona . The driver will call you beforehand. 30/12/2025 14:54

Carter
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Granada ? 30/12/2025 15:03

Roman Tsibulsky
Hello Carter, your shipment is in the customs warehouse, in the interval from 10:00-12:00 your manager Natalia will contact you. 30/12/2025 15:05

Mia
How to contact you for shipment tracking ? Industrial vibrating screen VS-04. 30/12/2025 15:13

Roman Tsibulsky
Good afternoon, Mia, My WhastApp is +79853643808, Manager Natalia +79153808881 during business hours and except weekends. 30/12/2025 15:13

James
Good day, tell me need delivery in Las Vegas to the settlement in the distance of 20 km. Can you organize this? 30/12/2025 15:23

Roman Tsibulsky
James, Good afternoon, please send us an email to info@minipress.ru with the exact name of the equipment model, city, and your coordinates. We will calculate the delivery to you. 30/12/2025 15:24

Hazel
Dear Roman. Deadline (time) I am waiting for your quotation for a machine for removing tablets and capsules from blister packs MB-10 with delivery. 30/12/2025 15:33

Roman Tsibulsky
Hello Hazel, By the specified time we will send the offer to your e-mail. Now we are waiting for an answer from the transportation company on the delivery time to Miami . 30/12/2025 15:34

Daniel
Mixer with paddle for powders CX-100 what is the exact packing size ? 30/12/2025 15:43

Roman Tsibulsky
Daniel, Hello! Packing dimensions 1200x640x1000 mm, packing weight 250 kg. Please let me know when you receive the shipment. 30/12/2025 15:44

Olivia
Roman, can you tell me if my rotary tablet press RZJ-35 has been shipped yet? Don't send it yet, I will send to your factory in China drawings of new punches, different design. 30/12/2025 15:53

Roman Tsibulsky
Good afternoon, Olivia! We're pausing the shipment. Send drawings to the office mail. The terms of production of new punches 20 working days. 30/12/2025 15:54

Jayden
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Santorini, then I want to buy an automatic capsule machine model GN-28 30/12/2025 16:03

Roman Tsibulsky
Good afternoon, Jayden! On the first question - the shipment will arrive in Santorini In the afternoon. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 30/12/2025 16:05