СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / GRANULATION PROCESS IN TABLET PRODUCTION / Binders for wet granulation

Binders for wet granulation

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / GRANULATION PROCESS IN TABLET PRODUCTION / Binders for wet granulation

Binders for wet granulation

There are some requirements for the granulating liquid, one of them is that the granulating liquid must not dissolve the active ingredient. Water, aqueous ethanol solution, acetone and methylene chloride can be used as granulating liquid. A wide range of substances are used as binders for wet granulation in modern pharmaceutical production, for example: starch (5-15 % g/g), starch derivatives, cellulose derivatives, which improve the plasticity of granules, as well as gelatin (1-3 % g/g) and PVP (3-10 % g/g). The most common and effective wet granulation binder in the modern pharmaceutical industry is a synthetic polymer such as Collidon (PVP), the various grades of which (Collidon 25, 30 and 90F) are widely available on the market.

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Information updated : 09 / 12 / 2025
In stock
Manufacturer : 1 year for Binders for wet granulation

Model: Wet granulation

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Plasdon polymers have excellent bonding ability, good film forming properties, surfactant properties and high solubility in water and many solvents used in pharmaceutical applications. Due to this combination of properties, these polymers are widely used in a number of pharmaceuticals. Plasdone polymers have long been used as binding agents in wet granulation. Plasdone®S-630 Copovidone is a synthetic 60:40 linear polymer of N-vinyl-2 pyrrolidone and vinyl acetate. With its unique properties, Plasdone S-630 is well suited as a tablet binder for direct pressing and dry granulation applications, as well as a wet granulation binder.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

The granules obtained with PVP are hard, easy to bulk, forming harder tablets with low brittleness. PVP polymer improves the solubility of the active ingredient by forming complexes. In addition, PVP acts as a crystallization inhibitor. The regularities presented below were identified by BASF’s fine chemistry department. They are discussed using Collidon as an example. Wet granulation using Collidon 25, Collidon 30 and Collidon 90F generally results in a harder granular material with better bulk properties than other binders – less abrasion and higher bond strength. The polymer content of the granulating fluid used can vary from Collidon 25 – 2-5%; Collidon 30 – 2-5%; Collidon 90F – 1-3%.

Additional information

Thus, BASF’s research showed that Collidon 90F produced the highest tablet hardness at the same pressing pressure. All binders were used in the amount of 3%. Based on the data presented, it can be concluded that the increased hardness and reduced brittleness of calcium phosphate tablets when Collidon 30 is used as a binder in the wet granulation process. In addition to Collidon, there are a large number of substances used as binders in the pharmaceutical industry. Let us consider two of them. PlasdonPPovidone is a series of synthetic water-soluble homopolymers of N-vinyl-2 pyrrolidone.

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John
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in Tempe 22/12/2025 01:09

Roman Tsibulsky
Hello John, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 22/12/2025 01:12

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Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 22/12/2025 01:19

Roman Tsibulsky
Good afternoon Owen, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. after lunch we will get a reply from the manufacturer on the final time frame. 22/12/2025 01:23

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RZW-29 rotary tablet press in Strasbourg. Regards, Elijah. 22/12/2025 01:29

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Good afternoon, Layla, My WhastApp is +79853643808, Manager Natalia +79153808881 during business hours and except weekends. 22/12/2025 01:42

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Good day, delivery time of semi-automatic drum filling machine DF-10 to Hum, will the courier call us? 22/12/2025 01:59

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Matthew, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 22/12/2025 02:03

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HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Cavala. 22/12/2025 02:19

Roman Tsibulsky
Hello Elijah, Delivery status checked, tomorrow until 14:30 is arriving at Cavala . The driver will call you beforehand. 22/12/2025 02:20

Savannah
To what address to send you samples of bottles and caps to send them to the factory ? Regards Savannah. 22/12/2025 02:29

Roman Tsibulsky
Good day, Savannah We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 22/12/2025 02:30

Ava
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in Phoenix 22/12/2025 02:39

Roman Tsibulsky
Hello Ava, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 22/12/2025 02:39