СATALOGUE / DRYING OF BULK MATERIALS IN A FLUIDIZED BED / Combining spray drying and freeze drying

Combining spray drying and freeze drying

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СATALOGUE / DRYING OF BULK MATERIALS IN A FLUIDIZED BED / Combining spray drying and freeze drying

Combining spray drying and freeze drying

The evaporation surface and the thickness of the frozen material layer play a significant role in improving heat and mass transfer. Increasing the evaporation surface is achieved by increasing the dispersibility and specific surface area of the material. This can be accomplished by atomization and additional pulverization of the frozen product, which allows to obtain a product of high dispersibility. According to preliminary estimates, the cost of removing 1 kg of moisture by spray drying is 6 times less than freeze drying. At the same time, transportation costs are significantly lower, and the condition of the products is stable during long-term storage. However, research has shown that spray drying can only be used for microorganisms that can withstand high temperatures.

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Information updated : 28 / 03 / 2026
In stock
Manufacturer : 1 year for Combining spray drying and freeze drying

Model: Combining spray drying and freeze drying

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Powders obtained by spray drying and combined spray and freeze drying have fundamental differences in particle shape. At the same time, the residual moisture content, surface properties of particles obtained by these two methods were similar. In both cases, the bulkiness was unsatisfactory. With the use of additives, an improvement in bulkiness was observed. In view of the above, it becomes obvious that there is a need to improve the energy efficiency of freeze dehydration technology, to develop new equipment, to create combined drying methods aimed at improving the quality of the obtained products. One of the tasks of improving the process of freeze drying (reducing the duration, energy consumption of the process) with simultaneous solution of the problems of quality of the obtained products can be solved by transition from drying in vacuum to drying at atmospheric pressure.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

For most crops, however, freeze drying remains the only suitable method. Recent research by scientists has shown that spray drying and freeze drying can be combined in a single process to produce protein-rich dry powders, with the main advantage of obtaining a highly dispersed product.
The process was carried out in two stages: spraying of the solution in a metal container filled with liquid nitrogen under constant shaking; freeze drying in a Crist vacuum lyophilizer. At the same time, the quality of products dried by the combined method (degree of preservation of valuable properties, original structure, activity of ingredients) is not inferior to freeze-dried in vacuum.

Additional information

The products have better bulkiness and morphology, and there is no sintering of the top layer. The powders obtained in this way can be used for further encapsulation, pressing, epidermal administration, as well as for increasing the solubility of poorly soluble substances. Some scientists have also investigated the effect of the drying method on powder friability, which depends on a combination of different factors: size, shape, and surface properties of the particles. The comparison of spray and combined spray and freeze drying methods was carried out in terms of such indicators as: particle size and shape; moisture content, physical and chemical properties; the influence of additives and coatings on the friability of powders.

Order status tracking

Roman Tsibulsky +79853643808 now online

Emily
Roman, can you tell me if my rotary tablet press RZJ-35 has been shipped yet? Don't send it yet, I will send to your factory in China drawings of new punches, different design. 01/04/2026 11:39

Roman Tsibulsky
Good afternoon, Emily! We're pausing the shipment. Send drawings to the office mail. The terms of production of new punches 20 working days. 01/04/2026 11:42

Elijah
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Bruges, do you deliver to the terminal or to the actual address? 01/04/2026 11:49

Roman Tsibulsky
Hello Elijah, we deliver all over USA including to Bruges . The price in the catalog includes any delivery our customer asks for. 01/04/2026 11:50

Scarlett
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Liverpool, then I want to buy an automatic capsule machine model GN-28 01/04/2026 11:59

Roman Tsibulsky
Good afternoon, Scarlett! On the first question - the shipment will arrive in Liverpool the day after tomorrow. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 01/04/2026 12:00

Oliver
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 01/04/2026 12:09

Roman Tsibulsky
Oliver, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Orora ? Contact Natalia, she will send the contract and invoice. 01/04/2026 12:12

Logan
Good day, I want tomorrow until 18: 30 to get FF-02 tablet and capsule filling machine in Zurich? 01/04/2026 12:19

Roman Tsibulsky
Good afternoon, Logan! We have contacted the transportation company, your shipment is arriving in Zurich without delay. Please wait for a call from a representative of Business Lines. 01/04/2026 12:23

Abigail
Roman, can you tell me if my rotary tablet press RZJ-35 has been shipped yet? Don't send it yet, I will send to your factory in China drawings of new punches, different design. 01/04/2026 12:29

Roman Tsibulsky
Good afternoon, Abigail! We're pausing the shipment. Send drawings to the office mail. The terms of production of new punches 20 working days. 01/04/2026 12:31

Layla
Can your technician come to Granada? We need technologist consultation and assistance. 01/04/2026 12:39

Roman Tsibulsky
Layla, We have already received your email. A technician tomorrow by lunchtime will contact you. Don't worry. 01/04/2026 12:42

Stella
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Dublin ? 01/04/2026 12:49

Roman Tsibulsky
Hello Stella, Expect In the afternoon. Once received, please let us know. 01/04/2026 12:51

Amelia
Roman, our company bought VL-100 V-shaped powder mixer, but it is not enough for us, can we return it and exchange it for V-300 model? 01/04/2026 12:59

Roman Tsibulsky
Amelia, good afternoon. When we corresponded with you, I warned you that this is a model with a small load. Unfortunately we can not pick up the equipment. As an option, we will offer our customers with a discount. 01/04/2026 13:02

Oliver
Good afternoon, please confirm that In the afternoon we will receive our shipment in Vienna? Contact the transportation company. 01/04/2026 13:09

Roman Tsibulsky
Hello Oliver ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Vienna in a few days. Please expect it. 01/04/2026 13:13