СATALOGUE / DRYING OF BULK MATERIALS IN A FLUIDIZED BED / Combining spray drying and freeze drying

Combining spray drying and freeze drying

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СATALOGUE / DRYING OF BULK MATERIALS IN A FLUIDIZED BED / Combining spray drying and freeze drying

Combining spray drying and freeze drying

The evaporation surface and the thickness of the frozen material layer play a significant role in improving heat and mass transfer. Increasing the evaporation surface is achieved by increasing the dispersibility and specific surface area of the material. This can be accomplished by atomization and additional pulverization of the frozen product, which allows to obtain a product of high dispersibility. According to preliminary estimates, the cost of removing 1 kg of moisture by spray drying is 6 times less than freeze drying. At the same time, transportation costs are significantly lower, and the condition of the products is stable during long-term storage. However, research has shown that spray drying can only be used for microorganisms that can withstand high temperatures.

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Information updated : 07 / 02 / 2026
In stock
Manufacturer : 1 year for Combining spray drying and freeze drying

Model: Combining spray drying and freeze drying

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Powders obtained by spray drying and combined spray and freeze drying have fundamental differences in particle shape. At the same time, the residual moisture content, surface properties of particles obtained by these two methods were similar. In both cases, the bulkiness was unsatisfactory. With the use of additives, an improvement in bulkiness was observed. In view of the above, it becomes obvious that there is a need to improve the energy efficiency of freeze dehydration technology, to develop new equipment, to create combined drying methods aimed at improving the quality of the obtained products. One of the tasks of improving the process of freeze drying (reducing the duration, energy consumption of the process) with simultaneous solution of the problems of quality of the obtained products can be solved by transition from drying in vacuum to drying at atmospheric pressure.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

For most crops, however, freeze drying remains the only suitable method. Recent research by scientists has shown that spray drying and freeze drying can be combined in a single process to produce protein-rich dry powders, with the main advantage of obtaining a highly dispersed product.
The process was carried out in two stages: spraying of the solution in a metal container filled with liquid nitrogen under constant shaking; freeze drying in a Crist vacuum lyophilizer. At the same time, the quality of products dried by the combined method (degree of preservation of valuable properties, original structure, activity of ingredients) is not inferior to freeze-dried in vacuum.

Additional information

The products have better bulkiness and morphology, and there is no sintering of the top layer. The powders obtained in this way can be used for further encapsulation, pressing, epidermal administration, as well as for increasing the solubility of poorly soluble substances. Some scientists have also investigated the effect of the drying method on powder friability, which depends on a combination of different factors: size, shape, and surface properties of the particles. The comparison of spray and combined spray and freeze drying methods was carried out in terms of such indicators as: particle size and shape; moisture content, physical and chemical properties; the influence of additives and coatings on the friability of powders.

Order status tracking

Roman Tsibulsky +79853643808 now online

Lily
Dear Roman. Deadline (time) I am waiting for your quotation for a machine for removing tablets and capsules from blister packs MB-10 with delivery. 12/02/2026 19:50

Roman Tsibulsky
Hello Lily, By the specified time we will send the offer to your e-mail. Now we are waiting for an answer from the transportation company on the delivery time to Las Vegas . 12/02/2026 19:51

Hazel
In Stavanger ITA-01 tablet and capsule counter, RZ-9 rotary tablet press and manual capsule filling machine. Help when we get it ? 12/02/2026 20:00

Roman Tsibulsky
Good afternoon, Hazel! We have received from the factories photos of the equipment after packing. Natalia will forward the photos to you. Delivery time to you is 45-50 days. 12/02/2026 20:01

Lucas
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in Cleveland 12/02/2026 20:10

Roman Tsibulsky
Hello Lucas, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 12/02/2026 20:12

Samuel
Natalia tell me, automatic double-sided labeling machine ST-36 has left the factory, invoice #118. 12/02/2026 20:20

Roman Tsibulsky
Hello Samuel, The equipment has been shipped from the transit warehouse and delivery is proceeding as planned. No delays are expected. 12/02/2026 20:21

Sebastian
Rotary tablet press RZK-25 I want to order with delivery to Berlin 12/02/2026 20:30

Roman Tsibulsky
Good day, Sebastian We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 12/02/2026 20:32

Noah
You have to pay for delivery to Ljubljana over and above the delivery amount in the contract ? 12/02/2026 20:40

Roman Tsibulsky
Noah, The catalog shows the price with door delivery. The unloading of the equipment, upon receipt of the shipment, will be charged to you separately. 12/02/2026 20:43

Matthew
Good afternoon! semi-automatic liquid filling machine in barrels DF-13 , a copy of the payment is sent to the post. Start the order to work. 12/02/2026 20:50

Roman Tsibulsky
Matthew, good afternoon! We have seen your payment, we receive SMS from the bank. Please send drawings of barrels and answers to our questions in correspondence. 12/02/2026 20:53

Hazel
Dear Roman. Deadline (time) I am waiting for your quotation for a machine for removing tablets and capsules from blister packs MB-10 with delivery. 12/02/2026 21:00

Roman Tsibulsky
Hello Hazel, By the specified time we will send the offer to your e-mail. Now we are waiting for an answer from the transportation company on the delivery time to Miami . 12/02/2026 21:04

Gabriel
For shipping to Nice do you have to pay anything extra ? 12/02/2026 21:10

Roman Tsibulsky
Good day Gabriel, In our catalog, all prices are inclusive of shipping to the customer's door. Delivery to Nice is included. 12/02/2026 21:13

William
Good day, tell me need delivery in Memphis to the settlement in the distance of 20 km. Can you organize this? 12/02/2026 21:20

Roman Tsibulsky
William, Good afternoon, please send us an email to info@minipress.ru with the exact name of the equipment model, city, and your coordinates. We will calculate the delivery to you. 12/02/2026 21:24