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Powders obtained by spray drying and combined spray and freeze drying have fundamental differences in particle shape. At the same time, the residual moisture content, surface properties of particles obtained by these two methods were similar. In both cases, the bulkiness was unsatisfactory. With the use of additives, an improvement in bulkiness was observed. In view of the above, it becomes obvious that there is a need to improve the energy efficiency of freeze dehydration technology, to develop new equipment, to create combined drying methods aimed at improving the quality of the obtained products. One of the tasks of improving the process of freeze drying (reducing the duration, energy consumption of the process) with simultaneous solution of the problems of quality of the obtained products can be solved by transition from drying in vacuum to drying at atmospheric pressure.
Pharmaceutical Glossary
Technical specifications
For most crops, however, freeze drying remains the only suitable method. Recent research by scientists has shown that spray drying and freeze drying can be combined in a single process to produce protein-rich dry powders, with the main advantage of obtaining a highly dispersed product.
The process was carried out in two stages: spraying of the solution in a metal container filled with liquid nitrogen under constant shaking; freeze drying in a Crist vacuum lyophilizer. At the same time, the quality of products dried by the combined method (degree of preservation of valuable properties, original structure, activity of ingredients) is not inferior to freeze-dried in vacuum.
Additional information
The products have better bulkiness and morphology, and there is no sintering of the top layer. The powders obtained in this way can be used for further encapsulation, pressing, epidermal administration, as well as for increasing the solubility of poorly soluble substances. Some scientists have also investigated the effect of the drying method on powder friability, which depends on a combination of different factors: size, shape, and surface properties of the particles. The comparison of spray and combined spray and freeze drying methods was carried out in terms of such indicators as: particle size and shape; moisture content, physical and chemical properties; the influence of additives and coatings on the friability of powders.
Order status tracking
How to contact you for shipment tracking ? Industrial vibrating screen VS-04. 30/01/2026 01:55
Good afternoon, Chloe, My WhastApp is +79853643808, Manager Natalia +79153808881 during business hours and except weekends. 30/01/2026 01:56
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled after lunch to open the box and test. 30/01/2026 02:05
Benjamin, good afternoon. Great news, please send a photo and video report to WhatsApp +79853643808. 30/01/2026 02:09
To what address to send you samples of bottles and caps to send them to the factory ? Regards Oliver. 30/01/2026 02:15
Good day, Oliver We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 30/01/2026 02:17
For shipping to Oslo do you have to pay anything extra ? 30/01/2026 02:25
Good day Ethan, In our catalog, all prices are inclusive of shipping to the customer's door. Delivery to Oslo is included. 30/01/2026 02:26
HX-6 Plastic Tube Filling and Sealing Machine in Istanbul? Price delivery terms and conditions 30/01/2026 02:35
Daniel, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 30/01/2026 02:37
Natalia tell me, automatic double-sided labeling machine ST-36 has left the factory, invoice #118. 30/01/2026 02:45
Hello Hannah, The equipment has been shipped from the transit warehouse and delivery is proceeding as planned. No delays are expected. 30/01/2026 02:46
I would like to discuss the purchase of model FK-05 - capping and screw cap machine. 30/01/2026 02:55
Good day. You can call on tel. +79853643808 or to the mail specified on the site. James, this chat is only for tracking shipments. 30/01/2026 02:57
We received our order (BG-150 film coating boiler) in the box there was no spraying nozzle !!! 30/01/2026 03:05
Hello Stella, we checked with the factory. Your nozzle was not received in time for the shipment of the main machine. We will now deliver it to you by DHL express mail. 30/01/2026 03:08
Can your technician come to Rome? We need technologist consultation and assistance. 30/01/2026 03:15
Isabella, We have already received your email. A technician tomorrow until 15:30 will contact you. Don't worry. 30/01/2026 03:16
The BB-152 liquid filling machine arrived from you today, remember us ? Where's the paperwork? 30/01/2026 03:25
{The original shipping documents will be delivered to Berlin tomorrow until 18: 30. Please send the signed copies to us. 30/01/2026 03:29
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- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR COATING TABLETS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
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