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Powders obtained by spray drying and combined spray and freeze drying have fundamental differences in particle shape. At the same time, the residual moisture content, surface properties of particles obtained by these two methods were similar. In both cases, the bulkiness was unsatisfactory. With the use of additives, an improvement in bulkiness was observed. In view of the above, it becomes obvious that there is a need to improve the energy efficiency of freeze dehydration technology, to develop new equipment, to create combined drying methods aimed at improving the quality of the obtained products. One of the tasks of improving the process of freeze drying (reducing the duration, energy consumption of the process) with simultaneous solution of the problems of quality of the obtained products can be solved by transition from drying in vacuum to drying at atmospheric pressure.
Pharmaceutical Glossary
Technical specifications
For most crops, however, freeze drying remains the only suitable method. Recent research by scientists has shown that spray drying and freeze drying can be combined in a single process to produce protein-rich dry powders, with the main advantage of obtaining a highly dispersed product.
The process was carried out in two stages: spraying of the solution in a metal container filled with liquid nitrogen under constant shaking; freeze drying in a Crist vacuum lyophilizer. At the same time, the quality of products dried by the combined method (degree of preservation of valuable properties, original structure, activity of ingredients) is not inferior to freeze-dried in vacuum.
Additional information
The products have better bulkiness and morphology, and there is no sintering of the top layer. The powders obtained in this way can be used for further encapsulation, pressing, epidermal administration, as well as for increasing the solubility of poorly soluble substances. Some scientists have also investigated the effect of the drying method on powder friability, which depends on a combination of different factors: size, shape, and surface properties of the particles. The comparison of spray and combined spray and freeze drying methods was carried out in terms of such indicators as: particle size and shape; moisture content, physical and chemical properties; the influence of additives and coatings on the friability of powders.
Order status tracking
Tell me the NJ-120 automatic capsule machine went ? 22/07/2025 04:22
Layla, good afternoon. Yes, already in the interval from 10:00-12:00 you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 22/07/2025 04:24
We're from New Jersey, we paid for the equipment on your invoice yesterday. Has the payment been received? How long will it take to deliver to us? 22/07/2025 04:32
Penelope, hello. Payment is credited to our settlement account. Term of manufacture of your equipment by the factory 20 working days, delivery from the factory to our warehouse in the USA 1 month, delivery from the warehouse in Pittsburgh 15 calendar days. 22/07/2025 04:33
I've been calling your office since this morning, and no one's picking up the phone. 22/07/2025 04:42
Good afternoon, Lily! The office will be open from 9:00 GMT. We'll be in touch. 22/07/2025 04:45
Horizontal granulator for organic fertilizers JU-80, the price is up to date ? Delivery time to Riga? Urgent. 22/07/2025 04:52
Ella, Please read carefully the description of this model in our catalog. Prices are current. Timing 1-1.5 months. 22/07/2025 04:52
PU-250 flow-pack packaging machine, please advise delivery status. 22/07/2025 05:02
Hello Logan, your equipment is undergoing customs clearance. Your manager Natalia will contact you closer to evening 22/07/2025 05:05
I've been calling your office since this morning, and no one's picking up the phone. 22/07/2025 05:12
Good afternoon, Grace! The office will be open from 9:00 GMT. We'll be in touch. 22/07/2025 05:14
Today we were promised delivery of a blister machine for MN-14 tablets and capsules, remember us ? No one's called us back. 22/07/2025 05:22
Hello Emma, Our manager Natalya tomorrow by lunchtime will dial the driver, also we ask you yourself to the transportation company. 22/07/2025 05:25
Automatic blister packaging machine for PVC+cardboard LW-35 with delivery to Kansas City. We want to track the delivery status. 22/07/2025 05:32
Ruby, hello. The shipment has already arrived. Now it is in the warehouse of the transportation company. Your manager will contact you to clarify the time of delivery to your city. 22/07/2025 05:35
Roman hello, what about the automatic filling and sealing machine for sterile ampoules ABF-4D-1, invoice #101. 22/07/2025 05:42
Good afternoon, Samuel! We are making a request to the manufacturer. Tomorrow we will send photos and video of testing to your e-mail. 22/07/2025 05:42
To what address to send you samples of bottles and caps to send them to the factory ? Regards John. 22/07/2025 05:52
Good day, John We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 22/07/2025 05:54
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR COATING TABLETS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR COATING TABLETS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS