Intra-shop control of ointments is carried out at almost every stage of production and especially before packing the drug. The final conclusion on all indicators of the quality of finished products is given by the quality control department of the plant. In the conditions of industrial production, the test is carried out in accordance with…
After the grinding and sieving operations, mixing follows, the purpose of which is to obtain a homogeneous mixture of powders. Mixing is usually carried out in parallel with grinding. This leads to the alignment of particle sizes and obtaining a more homogeneous mass. If a component is included in the mixture in a small amount,...
Tableting (pressing) is the process of forming tablets from granular or powdery material under pressure. In modern pharmaceutical production, tableting is carried out on special presses called tablet machines.
Fluidized bed dryer dryer uses a stream of hot air to keep the pellets in a “suspended” state in the pseudo-liquefied layer and dry them quickly, the spent water evaporates with the air flow. This equipment is used in the production of medical herbal preparations, combined powders, granules, lumpy materials, chemical products, etc. Quick drying….
Dry granulation is a method in which a powdery material (a mixture of medicinal and auxiliary substances) is compacted to produce a granulate. Dry granulation is used in cases where wet granulation affects the stability and/or physico-chemical characteristics of the medicinal substance, as well as when the medicinal and auxiliary substances are poorly compressed after...
From a physico-chemical point of view, suppositories are considered as dispersed systems consisting of a dispersion medium, represented by the basis of the Dispersed phase, in the role of which medicinal substances act. Depending on the properties of medicinal substances, dispersed systems of suppositories can be either homogeneous or heterogeneous. Homogeneous systems are formed when...
The ozone tunnel sterilization dryer ZXP-MG is used for drying and sterilization after washing plastic containers for eye drops, oral liquids in the pharmaceutical and food industries. The heating system and the ozonator of this machine can be controlled automatically and in a preset mode. The speed of the conveyor is regulated within a specified…
There are some requirements for the granulating liquid, one of them is that the granulating liquid should not dissolve the active substance. Water, an aqueous solution of ethanol, acetone and methylene chloride can be used as a granulating liquid. A wide range of substances are used as binding agents for wet granulation in modern pharmaceutical...
The whole pressing process is proposed to be divided into three stages: compaction (pre-pressing); formation of a compact body; volumetric compression of the resulting compact body. At the first stage of pressing, under the influence of an external force, the material particles converge and seal due to their displacement relative to each other and filling...
For most chemical and pharmaceutical preparations, the technology of tablet production consists of the following disparate operations of weighing the starting material, grinding, sieving, mixing, granulation, tableting (pressing), coating. Some of the listed operations in the manufacture of pharmaceuticals may be absent. Three common technological schemes for obtaining tablets are most common: using wet granulation,...
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