Technological properties of powdered medicine substances depend on their physicochemical properties. Fractional (particle size distribution) composition is the size distribution of powder particles. Fractional composition has a certain influence on the degree of bulkiness, hence, on the rhythmic operation of tablet machines, on the stability of the mass of tablets, the accuracy of dosage of medicine, on the qualitative characteristics of tablets (appearance, disintegration, strength, etc.). Studies of the fractional composition of pharmaceutical powders subject to tabletting have shown that most of them contain a fine fraction (less than 20 microns) and therefore have poor friability.
They are poorly dosed by volume on tabletting machines, and tablets are not uniform in mass and strength. The fractional composition of powders can be changed by directional granulation to produce a certain number of coarse fractions.
Granulated powders usually have a lumpy appearance with a relatively equiaxed shape and tend to contain a high percentage of the finest particles (less than 50 microns).This is due to the wet granulation process, which involves repeated mixing and powdering. The mixing and powdering process not only introduces a large number of fine particles into the mixture, but also pulverizes it.
Non-granulated powders are characterized by their polyfractional composition and complex shape. The average particle size of non-granulated powders is 30 to 120 microns.
As practice shows, for pharmaceutical production it is more indicative to characterize all significant fractions of the powder in order to make a conclusion about the possibility of its use in the technology of this or that medicine.
For example, with the help of conducted researches at JSC “Chemical-Pharmaceutical Combine “AKRIHIN” the fractional composition of substances used in production was determined by microscopy (particles smaller than 100 microns) and sieve analysis (particles larger than 100 microns). In sieve analysis, the material is separated into fractions by sieving through a standardized set of sieves for 5 minutes, and then the mass of each fraction and its percentage are determined.

Whatever your task, MINIPRESS is ready to take it on. We are more powerful than many competitors and our service is much more convenient. We provide our customers with impressive terms and amazingly fast turnaround times. Our specialists use the most advanced technologies in the world to select various equipment. We have everything you need for modern production of any level. And even more.