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The release of drugs from hydrophobic bases is slower.
When making suppositories, it should be remembered that the drug substances introduced into the composition of these dosage forms in the form of aqueous solutions, absorbed much easier and faster have a local effect than the drug substances introduced in dry form. In terms of microbiological purity of preparations for rectal administration are classified by the State Pharmacopoeia to category IIIA, ie in 1 g or 1 ml of the drug should contain no more than 1000 aerobic bacteria and 100 fungi in the absence of Escherichia coli.
Pharmaceutical Glossary
Technical specifications
All suppositories (especially rectal and urethral) must have sufficient hardness to overcome the resistance of tissues and sphincters, otherwise the suppositories are deformed and their use becomes impossible. The melting point determined for lipophilic suppositories should not exceed 37 °C. Moreover, it is necessary that their melting occurred in a short temperature range (1-2 ° C). If the definition of melting temperature causes difficulties, then set the time of full deformation, which should be no less than 3 and no more than 15 min. For suppositories made on hydrophilic bases, determine the time of dissolution in water, which should not exceed 1 h.
Additional information
The liquid mass formed after melting or dissolution of suppositories should spontaneously spread over the mucous membrane, forming a uniform layer. This condition is necessary to ensure close contact of the drug substance with tissues and its proper absorption. Suppositories should easily release the drug substances included in them. This quality depends both on the properties of the base used for the preparation of suppositories, and on the method of introduction of drugs into the base. Hydrophilic bases (except polyethylene oxides) easily release active substances, as they are able to dissolve in the secretions of mucous membranes.
Order status tracking
Hello Roman! Thank you for the service and quality of your products. We are very happy and satisfied with the purchase! 09/07/2026 22:16
Hello Amelia, Apparently you have tested your vacuum lyophilic dryer LZY-01. Its quality is above average, it will work. We are waiting for your new applications. 09/07/2026 22:19
Roman hello, what about the automatic filling and sealing machine for sterile ampoules ABF-4D-1, invoice #101. 09/07/2026 22:26
Good afternoon, Ethan! We are making a request to the manufacturer. Tomorrow we will send photos and video of testing to your e-mail. 09/07/2026 22:30
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 09/07/2026 22:36
Hello Noah, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 09/07/2026 22:38
When purchasing the RY-200 centrifugal type powder granulator, I asked for tests on our powder 09/07/2026 22:46
Hello Oliver, Please send 2 kg of your raw material to the address given to you by Natalia. After the test, the engineer will inform you about the results. 09/07/2026 22:47
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to Milwaukee. Thank you. 09/07/2026 22:56
Samuel, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to Milwaukee is scheduled for tomorrow until 18: 30. Please notify us upon receipt. 09/07/2026 22:59
Roman hello, what about the automatic filling and sealing machine for sterile ampoules ABF-4D-1, invoice #101. 09/07/2026 23:06
Good afternoon, James! We are making a request to the manufacturer. Tomorrow we will send photos and video of testing to your e-mail. 09/07/2026 23:09
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 09/07/2026 23:16
Good afternoon Samuel, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. before lunch we will get a reply from the manufacturer on the final time frame. 09/07/2026 23:19
YR-90 dry and wet powder granulator YR-90 month has already passed. Hurry up the factory. 09/07/2026 23:26
Alexander, good afternoon. The factory has shipped your equipment to our representative, now is forming a consolidated shipment for shipment to customs. We will keep you informed. 09/07/2026 23:28
PU-250 flow-pack packaging machine, please advise delivery status. 09/07/2026 23:36
Hello Luna, your equipment is undergoing customs clearance. Your manager Natalia will contact you closer to evening 09/07/2026 23:39
Good afternoon, please confirm that closer to evening we will receive our shipment in Bratislava? Contact the transportation company. 09/07/2026 23:46
Hello Olivia ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Bratislava in a few days. Please expect it. 09/07/2026 23:48
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