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The release of drugs from hydrophobic bases is slower.
When making suppositories, it should be remembered that the drug substances introduced into the composition of these dosage forms in the form of aqueous solutions, absorbed much easier and faster have a local effect than the drug substances introduced in dry form. In terms of microbiological purity of preparations for rectal administration are classified by the State Pharmacopoeia to category IIIA, ie in 1 g or 1 ml of the drug should contain no more than 1000 aerobic bacteria and 100 fungi in the absence of Escherichia coli.
Pharmaceutical Glossary
Technical specifications
All suppositories (especially rectal and urethral) must have sufficient hardness to overcome the resistance of tissues and sphincters, otherwise the suppositories are deformed and their use becomes impossible. The melting point determined for lipophilic suppositories should not exceed 37 °C. Moreover, it is necessary that their melting occurred in a short temperature range (1-2 ° C). If the definition of melting temperature causes difficulties, then set the time of full deformation, which should be no less than 3 and no more than 15 min. For suppositories made on hydrophilic bases, determine the time of dissolution in water, which should not exceed 1 h.
Additional information
The liquid mass formed after melting or dissolution of suppositories should spontaneously spread over the mucous membrane, forming a uniform layer. This condition is necessary to ensure close contact of the drug substance with tissues and its proper absorption. Suppositories should easily release the drug substances included in them. This quality depends both on the properties of the base used for the preparation of suppositories, and on the method of introduction of drugs into the base. Hydrophilic bases (except polyethylene oxides) easily release active substances, as they are able to dissolve in the secretions of mucous membranes.
Order status tracking
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 30/10/2024 17:14
Good afternoon Emily, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. between 16:00-18:00 we will get a reply from the manufacturer on the final time frame. 30/10/2024 17:14
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 30/10/2024 17:24
Hello James, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 30/10/2024 17:25
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled tomorrow by lunchtime to open the box and test. 30/10/2024 17:34
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Good afternoon, please confirm that as agreed we will receive our shipment in Vatican City? Contact the transportation company. 30/10/2024 17:44
Hello Natalie ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Vatican City in a few days. Please expect it. 30/10/2024 17:47
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to Anaheim. Thank you. 30/10/2024 17:54
Matthew, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to Anaheim is scheduled for in the interval from 10:00-12:00. Please notify us upon receipt. 30/10/2024 17:54
Automatic blister packaging machine for PVC+cardboard LW-35 with delivery to Dallas. We want to track the delivery status. 30/10/2024 18:04
Ava, hello. The shipment has already arrived. Now it is in the warehouse of the transportation company. Your manager will contact you to clarify the time of delivery to your city. 30/10/2024 18:04
PU-420 flow-pack packaging machine along with 500 kg packaging , delivery to Mesa. Please confirm the delivery time. 30/10/2024 18:14
Good afternoon Camila, your shipment has left. Arrival time tomorrow until 13:30. The driver will call you back later. Please organize prompt unloading. 30/10/2024 18:15
I would like to discuss the purchase of model FK-05 - capping and screw cap machine. 30/10/2024 18:24
Good day. You can call on tel. +79853643808 or to the mail specified on the site. Harper, this chat is only for tracking shipments. 30/10/2024 18:27
PU-250 flow-pack packaging machine, please advise delivery status. 30/10/2024 18:34
Hello Emily, your equipment is undergoing customs clearance. Your manager Natalia will contact you tomorrow until 17:30 30/10/2024 18:36
I've been calling your office since this morning, and no one's picking up the phone. 30/10/2024 18:44
Good afternoon, Alexander! The office will be open from 9:00 GMT. We'll be in touch. 30/10/2024 18:48
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