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The release of drugs from hydrophobic bases is slower.
When making suppositories, it should be remembered that the drug substances introduced into the composition of these dosage forms in the form of aqueous solutions, absorbed much easier and faster have a local effect than the drug substances introduced in dry form. In terms of microbiological purity of preparations for rectal administration are classified by the State Pharmacopoeia to category IIIA, ie in 1 g or 1 ml of the drug should contain no more than 1000 aerobic bacteria and 100 fungi in the absence of Escherichia coli.
Pharmaceutical Glossary
Technical specifications
All suppositories (especially rectal and urethral) must have sufficient hardness to overcome the resistance of tissues and sphincters, otherwise the suppositories are deformed and their use becomes impossible. The melting point determined for lipophilic suppositories should not exceed 37 °C. Moreover, it is necessary that their melting occurred in a short temperature range (1-2 ° C). If the definition of melting temperature causes difficulties, then set the time of full deformation, which should be no less than 3 and no more than 15 min. For suppositories made on hydrophilic bases, determine the time of dissolution in water, which should not exceed 1 h.
Additional information
The liquid mass formed after melting or dissolution of suppositories should spontaneously spread over the mucous membrane, forming a uniform layer. This condition is necessary to ensure close contact of the drug substance with tissues and its proper absorption. Suppositories should easily release the drug substances included in them. This quality depends both on the properties of the base used for the preparation of suppositories, and on the method of introduction of drugs into the base. Hydrophilic bases (except polyethylene oxides) easily release active substances, as they are able to dissolve in the secretions of mucous membranes.
Order status tracking
Good day, I want tomorrow until 18: 30 to get FF-02 tablet and capsule filling machine in Santorini? 01/03/2026 09:53
Good afternoon, Mia! We have contacted the transportation company, your shipment is arriving in Santorini without delay. Please wait for a call from a representative of Business Lines. 01/03/2026 09:53
Run through the order. V-shaped mixer for powders VM-50 and Mechanical tablet press PP-28 are waiting. 01/03/2026 10:03
Chloe, Checking delivery status. The shipment is already in Athens warehouse. Please arrange for pickup. 01/03/2026 10:03
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in Tucson 01/03/2026 10:13
Hello Stella, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 01/03/2026 10:14
In Marburg ITA-01 tablet and capsule counter, RZ-9 rotary tablet press and manual capsule filling machine. Help when we get it ? 01/03/2026 10:23
Good afternoon, Carter! We have received from the factories photos of the equipment after packing. Natalia will forward the photos to you. Delivery time to you is 45-50 days. 01/03/2026 10:23
Remember me? There's a delivery in the Paris 01/03/2026 10:33
Sofia, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be in the interval from 14:00-16:00 in Paris . 01/03/2026 10:37
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled tomorrow until 13:30 to open the box and test. 01/03/2026 10:43
Logan, good afternoon. Great news, please send a photo and video report to WhatsApp +79853643808. 01/03/2026 10:45
We're from New Jersey, we paid for the equipment on your invoice yesterday. Has the payment been received? How long will it take to deliver to us? 01/03/2026 10:53
Elijah, hello. Payment is credited to our settlement account. Term of manufacture of your equipment by the factory 20 working days, delivery from the factory to our warehouse in the USA 1 month, delivery from the warehouse in Memphis 15 calendar days. 01/03/2026 10:53
HX-6 Plastic Tube Filling and Sealing Machine in Oslo? Price delivery terms and conditions 01/03/2026 11:03
Lucy, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 01/03/2026 11:04
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Bucharest ? 01/03/2026 11:13
Hello Hannah, your shipment is in the customs warehouse, between 12:00-14:00 your manager Natalia will contact you. 01/03/2026 11:15
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Cinque Terre, do you deliver to the terminal or to the actual address? 01/03/2026 11:23
Hello Avery, we deliver all over USA including to Cinque Terre . The price in the catalog includes any delivery our customer asks for. 01/03/2026 11:25
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- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
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- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
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- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
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- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
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