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The release of drugs from hydrophobic bases is slower.
When making suppositories, it should be remembered that the drug substances introduced into the composition of these dosage forms in the form of aqueous solutions, absorbed much easier and faster have a local effect than the drug substances introduced in dry form. In terms of microbiological purity of preparations for rectal administration are classified by the State Pharmacopoeia to category IIIA, ie in 1 g or 1 ml of the drug should contain no more than 1000 aerobic bacteria and 100 fungi in the absence of Escherichia coli.
Pharmaceutical Glossary
Technical specifications
All suppositories (especially rectal and urethral) must have sufficient hardness to overcome the resistance of tissues and sphincters, otherwise the suppositories are deformed and their use becomes impossible. The melting point determined for lipophilic suppositories should not exceed 37 °C. Moreover, it is necessary that their melting occurred in a short temperature range (1-2 ° C). If the definition of melting temperature causes difficulties, then set the time of full deformation, which should be no less than 3 and no more than 15 min. For suppositories made on hydrophilic bases, determine the time of dissolution in water, which should not exceed 1 h.
Additional information
The liquid mass formed after melting or dissolution of suppositories should spontaneously spread over the mucous membrane, forming a uniform layer. This condition is necessary to ensure close contact of the drug substance with tissues and its proper absorption. Suppositories should easily release the drug substances included in them. This quality depends both on the properties of the base used for the preparation of suppositories, and on the method of introduction of drugs into the base. Hydrophilic bases (except polyethylene oxides) easily release active substances, as they are able to dissolve in the secretions of mucous membranes.
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Roman Tsibulsky +79853643808
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Layla
Rotary tablet press RZK-25 I want to order with delivery to Berlin 22/12/2025 05:02
Rotary tablet press RZK-25 I want to order with delivery to Berlin 22/12/2025 05:02
Roman Tsibulsky
Good day, Layla We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 22/12/2025 05:06
Good day, Layla We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 22/12/2025 05:06
Samuel
HX-6 Plastic Tube Filling and Sealing Machine in Madrid? Price delivery terms and conditions 22/12/2025 05:12
HX-6 Plastic Tube Filling and Sealing Machine in Madrid? Price delivery terms and conditions 22/12/2025 05:12
Roman Tsibulsky
Samuel, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 22/12/2025 05:15
Samuel, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 22/12/2025 05:15
Logan
Good afternoon, please confirm that in the interval from 14:00-16:00 we will receive our shipment in Crete? Contact the transportation company. 22/12/2025 05:22
Good afternoon, please confirm that in the interval from 14:00-16:00 we will receive our shipment in Crete? Contact the transportation company. 22/12/2025 05:22
Roman Tsibulsky
Hello Logan ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Crete in a few days. Please expect it. 22/12/2025 05:23
Hello Logan ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Crete in a few days. Please expect it. 22/12/2025 05:23
Elijah
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 22/12/2025 05:32
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 22/12/2025 05:32
Roman Tsibulsky
Hello Elijah, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 22/12/2025 05:35
Hello Elijah, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 22/12/2025 05:35
Alexander
Roman hello, what about the automatic filling and sealing machine for sterile ampoules ABF-4D-1, invoice #101. 22/12/2025 05:42
Roman hello, what about the automatic filling and sealing machine for sterile ampoules ABF-4D-1, invoice #101. 22/12/2025 05:42
Roman Tsibulsky
Good afternoon, Alexander! We are making a request to the manufacturer. Tomorrow we will send photos and video of testing to your e-mail. 22/12/2025 05:44
Good afternoon, Alexander! We are making a request to the manufacturer. Tomorrow we will send photos and video of testing to your e-mail. 22/12/2025 05:44
Bella
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Braila, but immediately upon arrival send it to Rotterdam. 22/12/2025 05:52
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Braila, but immediately upon arrival send it to Rotterdam. 22/12/2025 05:52
Roman Tsibulsky
Hello Bella, we will try to resolve this issue for you. 22/12/2025 05:56
Hello Bella, we will try to resolve this issue for you. 22/12/2025 05:56
Ella
When purchasing the RY-200 centrifugal type powder granulator, I asked for tests on our powder 22/12/2025 06:02
When purchasing the RY-200 centrifugal type powder granulator, I asked for tests on our powder 22/12/2025 06:02
Roman Tsibulsky
Hello Ella, Please send 2 kg of your raw material to the address given to you by Natalia. After the test, the engineer will inform you about the results. 22/12/2025 06:05
Hello Ella, Please send 2 kg of your raw material to the address given to you by Natalia. After the test, the engineer will inform you about the results. 22/12/2025 06:05
Olivia
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Mariehamn. 22/12/2025 06:12
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Mariehamn. 22/12/2025 06:12
Roman Tsibulsky
Hello Olivia, Delivery status checked, tomorrow until 12:30 is arriving at Mariehamn . The driver will call you beforehand. 22/12/2025 06:15
Hello Olivia, Delivery status checked, tomorrow until 12:30 is arriving at Mariehamn . The driver will call you beforehand. 22/12/2025 06:15
Layla
Good day, tell me need delivery in Jacksonville to the settlement in the distance of 20 km. Can you organize this? 22/12/2025 06:22
Good day, tell me need delivery in Jacksonville to the settlement in the distance of 20 km. Can you organize this? 22/12/2025 06:22
Roman Tsibulsky
Layla, Good afternoon, please send us an email to info@minipress.ru with the exact name of the equipment model, city, and your coordinates. We will calculate the delivery to you. 22/12/2025 06:24
Layla, Good afternoon, please send us an email to info@minipress.ru with the exact name of the equipment model, city, and your coordinates. We will calculate the delivery to you. 22/12/2025 06:24
David
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Cambridge. 22/12/2025 06:32
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Cambridge. 22/12/2025 06:32
Roman Tsibulsky
Hello David, Delivery status checked, tomorrow until 12:30 is arriving at Cambridge . The driver will call you beforehand. 22/12/2025 06:35
Hello David, Delivery status checked, tomorrow until 12:30 is arriving at Cambridge . The driver will call you beforehand. 22/12/2025 06:35
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- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR COATING TABLETS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- PERISTALTIC PUMPS DISPENSERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES