СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Standardization of suppositories in the pharmaceutical industry

Standardization of suppositories in the pharmaceutical industry

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Standardization of suppositories in the pharmaceutical industry

Standardization of suppositories in the pharmaceutical industry

All manufactured suppositories must meet the requirements of the State Pharmacopoeia XI: Suppositories must have a homogeneous mass. Homogeneity of suppository is checked visually on a longitudinal slice for the presence or absence of inclusions, pieces” of the basis, particles of different colors, other inclusions, while the presence of air rod is allowed. Deviations in the mass of suppositories are allowed within 5%. Suppositories should have the correct uniform shape. In suppositories, the drug substances must be accurately dosed. The suppositories must have a hardness that makes them easy to use.

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Information updated: 07 / 04 / 2026
Фармацевтическое оборудование в наличии и на заказ
Production: 1 year на оборудование для производства суппозиториев в фармацевтической отрасли

Model: Standardization of suppositories in the pharmaceutical industry

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The release of drugs from hydrophobic bases is slower.
When making suppositories, it should be remembered that the drug substances introduced into the composition of these dosage forms in the form of aqueous solutions, absorbed much easier and faster have a local effect than the drug substances introduced in dry form. In terms of microbiological purity of preparations for rectal administration are classified by the State Pharmacopoeia to category IIIA, ie in 1 g or 1 ml of the drug should contain no more than 1000 aerobic bacteria and 100 fungi in the absence of Escherichia coli.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

All suppositories (especially rectal and urethral) must have sufficient hardness to overcome the resistance of tissues and sphincters, otherwise the suppositories are deformed and their use becomes impossible. The melting point determined for lipophilic suppositories should not exceed 37 °C. Moreover, it is necessary that their melting occurred in a short temperature range (1-2 ° C). If the definition of melting temperature causes difficulties, then set the time of full deformation, which should be no less than 3 and no more than 15 min. For suppositories made on hydrophilic bases, determine the time of dissolution in water, which should not exceed 1 h.

Additional information

The liquid mass formed after melting or dissolution of suppositories should spontaneously spread over the mucous membrane, forming a uniform layer. This condition is necessary to ensure close contact of the drug substance with tissues and its proper absorption. Suppositories should easily release the drug substances included in them. This quality depends both on the properties of the base used for the preparation of suppositories, and on the method of introduction of drugs into the base. Hydrophilic bases (except polyethylene oxides) easily release active substances, as they are able to dissolve in the secretions of mucous membranes.

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Joseph
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 10/04/2026 23:10

Roman Tsibulsky
Joseph, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Chicago ? Contact Natalia, she will send the contract and invoice. 10/04/2026 23:10

Victoria
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Milan, do you deliver to the terminal or to the actual address? 10/04/2026 23:20

Roman Tsibulsky
Hello Victoria, we ship all over Europe and the US including to Milan . The price in the catalog includes any delivery our customer asks for. 10/04/2026 23:21

Olivia
Remember me? There's a delivery in the Zurich 10/04/2026 23:30

Roman Tsibulsky
Olivia, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be tomorrow until 16:30 in Zurich . 10/04/2026 23:33

Benjamin
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Lucca, but immediately upon arrival send it to Vienna. 10/04/2026 23:40

Roman Tsibulsky
Hello Benjamin, we will try to resolve this issue for you. 10/04/2026 23:40

Jayden
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Munich ? 10/04/2026 23:50

Roman Tsibulsky
Hello Jayden, your shipment is in the customs warehouse, tomorrow until 13:30 your manager Natalia will contact you. 10/04/2026 23:52

Layla
Roman, can you tell me if my rotary tablet press RZJ-35 has been shipped yet? Don't send it yet, I will send to your factory in China drawings of new punches, different design. 11/04/2026 00:00

Roman Tsibulsky
Good afternoon, Layla! We're pausing the shipment. Send drawings to the office mail. The terms of production of new punches 20 working days. 11/04/2026 00:03

James
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Bucharest ? 11/04/2026 00:10

Roman Tsibulsky
Hello James, your shipment is in the customs warehouse, tomorrow until 16:30 your manager Natalia will contact you. 11/04/2026 00:13

Hannah
Good day, I want after lunch to get FF-02 tablet and capsule filling machine in Prague? 11/04/2026 00:20

Roman Tsibulsky
Good afternoon, Hannah! We have contacted the transportation company, your shipment is arriving in Prague without delay. Please wait for a call from a representative of Business Lines. 11/04/2026 00:21

Eleanor
HX-6 Plastic Tube Filling and Sealing Machine in Vatican City? Price delivery terms and conditions 11/04/2026 00:30

Roman Tsibulsky
Eleanor, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 11/04/2026 00:32

Aria
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 11/04/2026 00:40

Roman Tsibulsky
Hello Aria, Our manager Natalia tomorrow until 18: 30 will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Mostar in 15 days. 11/04/2026 00:42