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The release of drugs from hydrophobic bases is slower.
When making suppositories, it should be remembered that the drug substances introduced into the composition of these dosage forms in the form of aqueous solutions, absorbed much easier and faster have a local effect than the drug substances introduced in dry form. In terms of microbiological purity of preparations for rectal administration are classified by the State Pharmacopoeia to category IIIA, ie in 1 g or 1 ml of the drug should contain no more than 1000 aerobic bacteria and 100 fungi in the absence of Escherichia coli.
Pharmaceutical Glossary
Technical specifications
All suppositories (especially rectal and urethral) must have sufficient hardness to overcome the resistance of tissues and sphincters, otherwise the suppositories are deformed and their use becomes impossible. The melting point determined for lipophilic suppositories should not exceed 37 °C. Moreover, it is necessary that their melting occurred in a short temperature range (1-2 ° C). If the definition of melting temperature causes difficulties, then set the time of full deformation, which should be no less than 3 and no more than 15 min. For suppositories made on hydrophilic bases, determine the time of dissolution in water, which should not exceed 1 h.
Additional information
The liquid mass formed after melting or dissolution of suppositories should spontaneously spread over the mucous membrane, forming a uniform layer. This condition is necessary to ensure close contact of the drug substance with tissues and its proper absorption. Suppositories should easily release the drug substances included in them. This quality depends both on the properties of the base used for the preparation of suppositories, and on the method of introduction of drugs into the base. Hydrophilic bases (except polyethylene oxides) easily release active substances, as they are able to dissolve in the secretions of mucous membranes.
Order status tracking
LW-35 automatic PVC+cardboard blister packaging machine has been on the road for 30 days. What news ? 26/03/2025 09:47
Hello Scarlett, We are on time, tomorrow until 13:30 a driver will contact you about unloading. 26/03/2025 09:48
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to Bakersfield. Thank you. 26/03/2025 09:57
Jackson, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to Bakersfield is scheduled for the day after tomorrow. Please notify us upon receipt. 26/03/2025 09:57
YR-90 dry and wet powder granulator YR-90 month has already passed. Hurry up the factory. 26/03/2025 10:07
Ethan, good afternoon. The factory has shipped your equipment to our representative, now is forming a consolidated shipment for shipment to customs. We will keep you informed. 26/03/2025 10:07
Dear Roman, good afternoon, vacuum powder conveyors QV-05 in quantity of 4 pieces, already on their way to Ceuta ? 26/03/2025 10:17
Good afternoon, Scarlett! Our manager has sent a scan of the bill of lading to your email. The shipment is on its way. 26/03/2025 10:18
Remember me? There's a delivery in the London 26/03/2025 10:27
Ethan, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be tomorrow until 12:30 in London . 26/03/2025 10:28
The MZ-10 expiration date and date handheld printer has still not been delivered. The driver did not answer and dropped calls yesterday. 26/03/2025 10:37
Hello Aurora, Transportation has advised that tomorrow until 14:30 driver will definitely deliver the box to your address. We apologize. 26/03/2025 10:39
Horizontal granulator for organic fertilizers JU-80, the price is up to date ? Delivery time to Istanbul? Urgent. 26/03/2025 10:47
Nova, Please read carefully the description of this model in our catalog. Prices are current. Timing 1-1.5 months. 26/03/2025 10:47
HX-6 Plastic Tube Filling and Sealing Machine in London? Price delivery terms and conditions 26/03/2025 10:57
Abigail, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 26/03/2025 10:58
I've been calling your office since this morning, and no one's picking up the phone. 26/03/2025 11:07
Good afternoon, Aria! The office will be open from 9:00 GMT. We'll be in touch. 26/03/2025 11:07
How to contact you for shipment tracking ? Industrial vibrating screen VS-04. 26/03/2025 11:17
Good afternoon, Joseph, My WhastApp is +79853643808, Manager Natalia +79153808881 during business hours and except weekends. 26/03/2025 11:17
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- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
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- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
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- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
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- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
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