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The release of drugs from hydrophobic bases is slower.
When making suppositories, it should be remembered that the drug substances introduced into the composition of these dosage forms in the form of aqueous solutions, absorbed much easier and faster have a local effect than the drug substances introduced in dry form. In terms of microbiological purity of preparations for rectal administration are classified by the State Pharmacopoeia to category IIIA, ie in 1 g or 1 ml of the drug should contain no more than 1000 aerobic bacteria and 100 fungi in the absence of Escherichia coli.
Pharmaceutical Glossary
Technical specifications
All suppositories (especially rectal and urethral) must have sufficient hardness to overcome the resistance of tissues and sphincters, otherwise the suppositories are deformed and their use becomes impossible. The melting point determined for lipophilic suppositories should not exceed 37 °C. Moreover, it is necessary that their melting occurred in a short temperature range (1-2 ° C). If the definition of melting temperature causes difficulties, then set the time of full deformation, which should be no less than 3 and no more than 15 min. For suppositories made on hydrophilic bases, determine the time of dissolution in water, which should not exceed 1 h.
Additional information
The liquid mass formed after melting or dissolution of suppositories should spontaneously spread over the mucous membrane, forming a uniform layer. This condition is necessary to ensure close contact of the drug substance with tissues and its proper absorption. Suppositories should easily release the drug substances included in them. This quality depends both on the properties of the base used for the preparation of suppositories, and on the method of introduction of drugs into the base. Hydrophilic bases (except polyethylene oxides) easily release active substances, as they are able to dissolve in the secretions of mucous membranes.
Order status tracking
RZW-29 rotary tablet press in Helsinki. Regards, Lila. 25/04/2025 22:51
Lila, Delivery will be made In the afternoon to Helsinki . Please have the movers ready. The weight of the equipment is heavy. 25/04/2025 22:53
Good afternoon, please confirm that closer to evening we will receive our shipment in Stockholm? Contact the transportation company. 25/04/2025 23:01
Hello Hannah ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Stockholm in a few days. Please expect it. 25/04/2025 23:02
Dear Roman. Deadline (time) I am waiting for your quotation for a machine for removing tablets and capsules from blister packs MB-10 with delivery. 25/04/2025 23:11
Hello John, By the specified time we will send the offer to your e-mail. Now we are waiting for an answer from the transportation company on the delivery time to El Paso . 25/04/2025 23:13
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 25/04/2025 23:21
Maya, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer tomorrow until 16:30. We will report back immediately. 25/04/2025 23:24
Tell me the NJ-120 automatic capsule machine went ? 25/04/2025 23:31
Amelia, good afternoon. Yes, already tomorrow until 16:30 you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 25/04/2025 23:34
Roman, can you tell me if my rotary tablet press RZJ-35 has been shipped yet? Don't send it yet, I will send to your factory in China drawings of new punches, different design. 25/04/2025 23:41
Good afternoon, Andrew! We're pausing the shipment. Send drawings to the office mail. The terms of production of new punches 20 working days. 25/04/2025 23:44
In Alexandrovka ITA-01 tablet and capsule counter, RZ-9 rotary tablet press and manual capsule filling machine. Help when we get it ? 25/04/2025 23:51
Good afternoon, Grace! We have received from the factories photos of the equipment after packing. Natalia will forward the photos to you. Delivery time to you is 45-50 days. 25/04/2025 23:53
Good day, delivery time of semi-automatic drum filling machine DF-10 to Kuressaare, will the courier call us? 26/04/2025 00:01
Oliver, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 26/04/2025 00:04
LW-35 automatic PVC+cardboard blister packaging machine has been on the road for 30 days. What news ? 26/04/2025 00:11
Hello Noah, We are on time, as agreed a driver will contact you about unloading. 26/04/2025 00:14
We have sent to info@minipress.ru photos of the damaged box with induction welding membrane machine FG-08. Please call back. 26/04/2025 00:21
Good day, Luna! Damage to the packaging is unfortunately a common practice in transportation. Please carefully unpack the shipment and send us a series of photos. We will take a look and take action. 26/04/2025 00:24
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- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
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- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
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- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
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- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
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- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
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- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- PERISTALTIC PUMPS DISPENSERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR MIXING POWDERS