СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Standardization of suppositories in the pharmaceutical industry

Standardization of suppositories in the pharmaceutical industry

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Standardization of suppositories in the pharmaceutical industry

Standardization of suppositories in the pharmaceutical industry

All manufactured suppositories must meet the requirements of the State Pharmacopoeia XI: Suppositories must have a homogeneous mass. Homogeneity of suppository is checked visually on a longitudinal slice for the presence or absence of inclusions, pieces” of the basis, particles of different colors, other inclusions, while the presence of air rod is allowed. Deviations in the mass of suppositories are allowed within 5%. Suppositories should have the correct uniform shape. In suppositories, the drug substances must be accurately dosed. The suppositories must have a hardness that makes them easy to use.

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Information updated : 09 / 03 / 2026
In stock
Manufacturer : 1 year for Standardization of suppositories in the pharmaceutical industry

Model: Standardization of suppositories in the pharmaceutical industry

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The release of drugs from hydrophobic bases is slower.
When making suppositories, it should be remembered that the drug substances introduced into the composition of these dosage forms in the form of aqueous solutions, absorbed much easier and faster have a local effect than the drug substances introduced in dry form. In terms of microbiological purity of preparations for rectal administration are classified by the State Pharmacopoeia to category IIIA, ie in 1 g or 1 ml of the drug should contain no more than 1000 aerobic bacteria and 100 fungi in the absence of Escherichia coli.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

All suppositories (especially rectal and urethral) must have sufficient hardness to overcome the resistance of tissues and sphincters, otherwise the suppositories are deformed and their use becomes impossible. The melting point determined for lipophilic suppositories should not exceed 37 °C. Moreover, it is necessary that their melting occurred in a short temperature range (1-2 ° C). If the definition of melting temperature causes difficulties, then set the time of full deformation, which should be no less than 3 and no more than 15 min. For suppositories made on hydrophilic bases, determine the time of dissolution in water, which should not exceed 1 h.

Additional information

The liquid mass formed after melting or dissolution of suppositories should spontaneously spread over the mucous membrane, forming a uniform layer. This condition is necessary to ensure close contact of the drug substance with tissues and its proper absorption. Suppositories should easily release the drug substances included in them. This quality depends both on the properties of the base used for the preparation of suppositories, and on the method of introduction of drugs into the base. Hydrophilic bases (except polyethylene oxides) easily release active substances, as they are able to dissolve in the secretions of mucous membranes.

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Muhammad
Rotary tablet press RZK-25 I want to order with delivery to Berlin 21/03/2026 20:10

Roman Tsibulsky
Good day, Muhammad We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 21/03/2026 20:14

Samuel
LW-35 automatic PVC+cardboard blister packaging machine has been on the road for 30 days. What news ? 21/03/2026 20:20

Roman Tsibulsky
Hello Samuel, We are on time, between 16:00-18:00 a driver will contact you about unloading. 21/03/2026 20:22

Jayden
Hello Roman! Thank you for the service and quality of your products. We are very happy and satisfied with the purchase! 21/03/2026 20:30

Roman Tsibulsky
Hello Jayden, Apparently you have tested your vacuum lyophilic dryer LZY-01. Its quality is above average, it will work. We are waiting for your new applications. 21/03/2026 20:30

Liam
Horizontal granulator for organic fertilizers JU-80, the price is up to date ? Delivery time to Cinque Terre? Urgent. 21/03/2026 20:40

Roman Tsibulsky
Liam, Please read carefully the description of this model in our catalog. Prices are current. Timing 1-1.5 months. 21/03/2026 20:42

Layla
Hello Roman! Thank you for the service and quality of your products. We are very happy and satisfied with the purchase! 21/03/2026 20:50

Roman Tsibulsky
Hello Layla, Apparently you have tested your vacuum lyophilic dryer LZY-01. Its quality is above average, it will work. We are waiting for your new applications. 21/03/2026 20:51

Alexander
Please inform me about the status of the order Rotary tablet press RZ-10A in Chicago ? 21/03/2026 21:00

Roman Tsibulsky
Good afternoon, Alexander. We have contacted the carrier, delivery is scheduled tomorrow until 18: 30. Please let us know when you receive it. Thank you. 21/03/2026 21:04

Noah
Contract #12, the deadline for delivery has already passed. Take action at last. Accelerate Tsibulsky R.G. 21/03/2026 21:10

Roman Tsibulsky
Hello Noah, we are on vacation on weekends and are not able to respond to messages. Raise the contract, delivery time of equipment to your warehouse in Copenhagen to 50 working ( not calendar) days. Action taken. 21/03/2026 21:10

Aiden
Dear Roman. Deadline (time) I am waiting for your quotation for a machine for removing tablets and capsules from blister packs MB-10 with delivery. 21/03/2026 21:20

Roman Tsibulsky
Hello Aiden, By the specified time we will send the offer to your e-mail. Now we are waiting for an answer from the transportation company on the delivery time to Tucson . 21/03/2026 21:22

Ethan
HX-6 Plastic Tube Filling and Sealing Machine in Santorini? Price delivery terms and conditions 21/03/2026 21:30

Roman Tsibulsky
Ethan, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 21/03/2026 21:31

Sophia
Tell me the NJ-120 automatic capsule machine went ? 21/03/2026 21:40

Roman Tsibulsky
Sophia, good afternoon. Yes, already between 16:00-18:00 you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 21/03/2026 21:44