СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MICROENCAPSULATION OF MEDICINE / Method based on the use of polymers and crosslinking agents

Method based on the use of polymers and crosslinking agents

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MICROENCAPSULATION OF MEDICINE / Method based on the use of polymers and crosslinking agents

Method based on the use of polymers and crosslinking agents

Cross-linking of polymer chains is carried out by introducing special substances into the system, which, as a result of ion exchange, form bonds between two neighboring chains. The process takes place at the interface. It is possible to use “oil-in-water” systems containing hydrophilic polymer and, for example, lower aldehydes as crosslinking agents. In this case, the interaction of the polymer with the aldehyde takes place in the aqueous phase, resulting in the formation of a new phase deposited on the oil droplets, since the higher aldehydes dissolve in the non-polar phase.

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Information updated : 10 / 01 / 2026
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Manufacturer : 1 year for Method based on the use of polymers and crosslinking agents

Model: Method based on the use of polymers and crosslinking agents

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At atomization in the electric field the formation of a “liquid needle” takes place, from the end 1 of which the droplets break off. To increase productivity when using the droplet method, the number of prillers in the apparatus for microencapsulation is increased. Preliminary obtaining of two-phase systems is also necessary when carrying out the process of microencapsulation by polymerization and polycondensation.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

“Solidification” of shells is carried out by changing the acidity of the medium to pH = 7. For preliminary separation of phases use either homogenizers (obtaining microemulsions), or drop method, in which the second phase is introduced into the first with the help of special devices – prillers. Simplistically, the priller can be represented as a thin needle through which the dispersed liquid is uniformly fed (mainly by means of high-precision plunger pumps).

Additional information

Similarly, as in the case of forming devices, droplet breakage can be realized under the influence of difference of applied potentials, high-frequency oscillations, rotating disks of different designs and by other means. Comparison of microcapsules allows us to note that when an electrostatic field is applied, the size of microcapsules becomes more homogeneous.

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