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Fewer excipients in the manufacture of capsules than, for example, in the manufacture of tablets. In addition, capsules require less machinery due to fewer production steps, fewer analytical techniques to be used in the required analyses, and fewer authorization procedures and documents than tablet production. In soft and hard capsules, drugs can be encapsulated in unaltered form without wet granulation, heat, and pressure as in tablet manufacturing. In addition, the number of factors affecting the processes of release and absorption of drugs from capsules is much smaller than for other dosage forms. A disadvantage of gelatin capsules is their high sensitivity to moisture, which requires compliance with certain conditions for their storage. Another disadvantage is the fact that gelatin is an excellent breeding ground for microorganisms. This disadvantage is prevented by adding preservatives to the mass: nipagin (0.4%), nipazole (0.4%), sorbic acid (0.1-0.2%) and others. Gelatin capsules may differ in capacity. At the same time hard capsules are produced worldwide in 8 standard sizes (Standart): from No. 5 (the smallest) to No. 000 (the largest). Some companies have mastered the production of an additional ninth size No. 0e1 (0 elongated, i.e. size 0 for elongated capsules). In addition to these, Supro capsules of five standard sizes from A to E have recently become widespread abroad.
Pharmaceutical Glossary
Technical specifications
Solid capsules are intended for dispensing loose powdery or granular substances. They have the shape of a cylinder with hemispherical ends and consist of two parts: a body and a cap; both parts must fit freely into each other without forming gaps. Hard capsules are filled after the molding process has been fully completed and they have acquired the appropriate elasticity and rigidity. Hard capsules have a two-part structure and can be manufactured in advance and filled with drug substances as needed. Soft capsules are designed for liquid or paste-like drug substances. Capsules have different shapes: spherical, ovoid, oblong or cylindrical with hemispherical ends. Soft capsules got their name due to the fact that in the process of their manufacture, the filler is placed in a still soft elastic shell. The capsules are then subjected to further manufacturing processes that may result in the original elasticity of the shell being partially or completely lost. Such capsules have a one-piece shell, which may be elastic or rigid. Sometimes the shell of soft capsules contains the active substance.Capsules are intended for oral, less often rectal, vaginal and other routes of administration. Depending on the localization of oral capsules are divided into sublingual, gastric-soluble and intestinal-soluble (resistant to the action of gastric juice, but easily destroyed in the environment of the small intestine). Modified-release capsules have special excipients in the contents or shell designed to change the rate or location of release of active ingredients. Intestinal soluble capsules are also classified as modified-release products, which must be stable in gastric juice and release the active ingredients in the intestine. They can be manufactured by coating hard or soft capsules with an acid-resistant shell or by filling capsules with granules or pellets coated with acid-resistant shells.
Additional information
Currently, the dosage form in the form of gelatin capsules has become very popular with pharmaceutical manufacturers, consumers and physicians due to a number of advantages and positive characteristics. These include, among others:
High dosing accuracy of the drug substances placed in them. Modern equipment ensures high accuracy of filling capsules with filler (with a tolerance not exceeding ±3%) and minimal losses. High bioavailability. Studies have shown that capsules often disintegrate faster in the human body than tablets or dragees, and their liquid or unabsorbed solid contents are more quickly and easily absorbed. The pharmacological action of the drug substance is manifested in 4-5 min. High stability. Drug substances in capsules are protected from various unfavorable environmental factors – the effects of light, air, moisture, mechanical influences – due to the shell, which provides a sufficiently high tightness and isolation of components. Therefore, in the manufacture of capsules it is possible to avoid the need to use antioxidants or stabilizers or reduce their amount.
Corrective ability – unpleasant taste and odor of medicinal substances is eliminated, which is especially important in pediatrics. High aesthetics – achieved through the use of various dyes in obtaining capsule shells. Today, leading pharmaceutical companies use up to 1,000 different colors and shades for coloring capsule shells.
Possibility to set specific properties of drug substances – creation of intestine-soluble capsules, as well as urethard capsules (with prolonged drug release), which can be achieved by various technological methods.
Order status tracking
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to New York. Thank you. 22/07/2024 03:46
Oliver, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to New York is scheduled for between 12:00-14:00. Please notify us upon receipt. 22/07/2024 03:48
YR-90 dry and wet powder granulator YR-90 month has already passed. Hurry up the factory. 22/07/2024 03:56
Hazel, good afternoon. The factory has shipped your equipment to our representative, now is forming a consolidated shipment for shipment to customs. We will keep you informed. 22/07/2024 03:59
Roman, can you tell me if my rotary tablet press RZJ-35 has been shipped yet? Don't send it yet, I will send to your factory in China drawings of new punches, different design. 22/07/2024 04:06
Good afternoon, Penelope! We're pausing the shipment. Send drawings to the office mail. The terms of production of new punches 20 working days. 22/07/2024 04:06
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 22/07/2024 04:16
Layla, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Austin ? Contact Natalia, she will send the contract and invoice. 22/07/2024 04:17
Mixer with paddle for powders CX-100 what is the exact packing size ? 22/07/2024 04:26
Liam, Hello! Packing dimensions 1200x640x1000 mm, packing weight 250 kg. Please let me know when you receive the shipment. 22/07/2024 04:29
Automatic blister packaging machine for PVC+cardboard LW-35 with delivery to El Paso. We want to track the delivery status. 22/07/2024 04:36
Ruby, hello. The shipment has already arrived. Now it is in the warehouse of the transportation company. Your manager will contact you to clarify the time of delivery to your city. 22/07/2024 04:40
Good afternoon, please confirm that closer to evening we will receive our shipment in USA? Contact the transportation company. 22/07/2024 04:46
Hello Daniel ! Representatives of the transportation company on the delivery status of your shipment said that it will be in USA in a few days. Please expect it. 22/07/2024 04:49
Roman, our company bought VL-100 V-shaped powder mixer, but it is not enough for us, can we return it and exchange it for V-300 model? 22/07/2024 04:56
Ava, good afternoon. When we corresponded with you, I warned you that this is a model with a small load. Unfortunately we can not pick up the equipment. As an option, we will offer our customers with a discount. 22/07/2024 04:57
Good afternoon, please confirm that tomorrow by lunchtime we will receive our shipment in USA? Contact the transportation company. 22/07/2024 05:06
Hello Chloe ! Representatives of the transportation company on the delivery status of your shipment said that it will be in USA in a few days. Please expect it. 22/07/2024 05:08
I've been calling your office since this morning, and no one's picking up the phone. 22/07/2024 05:16
Good afternoon, Benjamin! The office will be open from 9:00 GMT. We'll be in touch. 22/07/2024 05:17
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING