СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / Force to push tablets out of the matrix

Force to push tablets out of the matrix

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / Force to push tablets out of the matrix

Force to push tablets out of the matrix

To push the pressed tablet out of the die, a force is required to overcome the friction and adhesion between the side of the tablet and the die wall. Based on the magnitude of the ejection force, additions of sliding (sliding or lubricating) agents are predicted. As an example, the results of determining the technological characteristics of rounded-shaped substances are presented. Powders with rounded particles with basic particle size more than 100 microns (Ranitidine g/hl, carbamazepine, phenazepam) have high (8-9 g/s) bulkiness, high volumetric density before and after compaction, but insignificant compressibility and small compaction coefficient.
Phenazepam has a slightly lower bulkiness value (8 g/s), probably because it contains more fines and does not contain particles larger than 250 microns, which are present in ranitidine and carbamazepine.

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Information updated : 09 / 12 / 2025
In stock
Manufacturer : 1 year for Force to push tablets out of the matrix

Model: Force to push tablets out of the matrix

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The image of the object surface topography is visually observed on the monitor screen and recorded on large-format photographic film. The principle of operation of the electron scanning microscope is as follows: a narrow beam of electrons with kinetic energy of the order of 1-25 kV falls on the sample under study. Electrons of the reflected beam (secondary electrons), released by atoms on the surface, form an image that is registered on the screen or microphotograph. In order to avoid sample damage or combustion, the sample is pre-coated with a conductive layer (usually a thin layer of gold) to prevent charging of the surface. The method of electron scanning microscopy allows to determine with high resolution the structure of the studied samples, shape and size of particles, pore size, pore size distribution, surface porosity and visualize pore geometry.

Pharmaceutical Glossary

Antifriction agents — A group of materials that have a low coefficient of friction, or materials that can reduce the coefficient of friction of other materials.

Technical specifications

This once again proves the fact that the finer the particles, the lower the friability.
The above-described technological characteristics of powdered drug substances are of paramount importance in the development of composition and technology of tablet forms, which should provide the necessary bioavailability and, accordingly, the effectiveness and safety of the drug.
Technological characteristics of powders are established quickly enough, methods of their determination are simple and do not cause difficulties, therefore these methods are now widely used in the pharmaceutical industry for mass control of all incoming drug substances.

Additional information

As a rule, pharmaceutical companies analyze the dispersibility of drug substances by such available methods as sieve analysis, microscopy, using a laser particle analyzer, etc. This allows already at the stage of selection of firms-suppliers of drug substances to exclude non-standard substances in the developed technological process and ensure high quality of domestic tablet preparations. The method of electron scanning microscopy can be used to determine such properties as surface, shape and size of particles. Stationary electron scanning microscope designed to study the topography (microgeometry) of the surface of a solid body by secondary electron emission.

Order status tracking

Roman Tsibulsky +79853643808 now online

Nora
Good afternoon, please confirm that as agreed we will receive our shipment in Oslo? Contact the transportation company. 20/12/2025 07:47

Roman Tsibulsky
Hello Nora ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Oslo in a few days. Please expect it. 20/12/2025 07:49

Emily
Automatic blister packaging machine for PVC+cardboard LW-35 with delivery to Chicago. We want to track the delivery status. 20/12/2025 07:57

Roman Tsibulsky
Emily, hello. The shipment has already arrived. Now it is in the warehouse of the transportation company. Your manager will contact you to clarify the time of delivery to your city. 20/12/2025 08:00

Lily
YR-90 dry and wet powder granulator YR-90 month has already passed. Hurry up the factory. 20/12/2025 08:07

Roman Tsibulsky
Lily, good afternoon. The factory has shipped your equipment to our representative, now is forming a consolidated shipment for shipment to customs. We will keep you informed. 20/12/2025 08:08

Ethan
The BB-152 liquid filling machine arrived from you today, remember us ? Where's the paperwork? 20/12/2025 08:17

Roman Tsibulsky
{The original shipping documents will be delivered to York in the interval from 10:00-12:00. Please send the signed copies to us. 20/12/2025 08:19

Lily
Rotary tablet press RZK-25 I want to order with delivery to Berlin 20/12/2025 08:27

Roman Tsibulsky
Good day, Lily We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 20/12/2025 08:30

Bella
LW-35 automatic PVC+cardboard blister packaging machine has been on the road for 30 days. What news ? 20/12/2025 08:37

Roman Tsibulsky
Hello Bella, We are on time, tomorrow until 15:30 a driver will contact you about unloading. 20/12/2025 08:38

Elijah
LW-35 automatic PVC+cardboard blister packaging machine has been on the road for 30 days. What news ? 20/12/2025 08:47

Roman Tsibulsky
Hello Elijah, We are on time, between 12:00-14:00 a driver will contact you about unloading. 20/12/2025 08:51

Eleanor
I've been calling your office since this morning, and no one's picking up the phone. 20/12/2025 08:57

Roman Tsibulsky
Good afternoon, Eleanor! The office will be open from 9:00 GMT. We'll be in touch. 20/12/2025 08:59

Daniel
The MZ-10 expiration date and date handheld printer has still not been delivered. The driver did not answer and dropped calls yesterday. 20/12/2025 09:07

Roman Tsibulsky
Hello Daniel, Transportation has advised that after lunch driver will definitely deliver the box to your address. We apologize. 20/12/2025 09:11

Eleanor
Mixer with paddle for powders CX-100 what is the exact packing size ? 20/12/2025 09:17

Roman Tsibulsky
Eleanor, Hello! Packing dimensions 1200x640x1000 mm, packing weight 250 kg. Please let me know when you receive the shipment. 20/12/2025 09:21