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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / Classification of soft dosage forms

Classification of soft dosage forms

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  • Production of creams
  • Production of ointments
  • Classification of soft dosage forms
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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / Classification of soft dosage forms

Classification of soft dosage forms

Based on the above, the following classification of soft dosage forms is proposed:

1. Ointments by type of base are divided into three groups: hydrophobic (lipophilic), hydrophobic absorption (emulsion) and hydrophilic ointments.
Hydrophobic (lipophilic) ointments are prepared mainly on hydrocarbon bases (vaseline, vaseline oil, paraffin) and may contain other lipophilic excipients (vegetable oils, animal fats, waxes, synthetic glycerides and liquid polyalkylsi-loxanes). Only small amounts of water or aqueous solutions may be introduced into their composition. Hydrophobic ointments when applied have occlusive (preventing contact with air) effect, have a softening effect, are difficult to wash off with water and do not mix with exudate. Hydrophobic absorbent ointments. Absorbent ointments are hydrophobic, but may absorb (emulsify) exudate when rubbed into the skin. Their bases can be divided into two groups:
hydrophobic bases consisting of hydrocarbons and water-oil emulsifiers (petroleum jelly and lanolin or wool wax alcohols), into which significant amounts of water or aqueous solutions may be introduced to form a water-oil emulsion;
hydrophobic bases, which are water-oil or oil-water-oil emulsions (petroleum jelly and aqueous lanolin). Water or an aqueous solution may additionally be introduced into their composition by emulsification. Hydrophilic ointments are generally hyperosmolar, and as a result may absorb a significant amount of exudate during application. Bases for them can be divided into two groups: water-soluble bases, which usually contain hydrophilic non-aqueous solvents (polyethylene glycol 400, propylene glycol, etc.) and sufficiently high concentrations of water-soluble polymers (polyethylene glycol 1500, proxanol 268, etc.); water-washable bases, which usually contain hydrophilic non-aqueous solvents (polyethylene glycol 400, propylene glycol, etc.). ); water-washable bases, which, in addition to water-soluble polymers and hydrophilic non-aqueous solvents, contain lipophilic substances (higher fatty alcohols, vaseline, vaseline oil, lanolin, waxes, etc.). These bases are usually oil-in-water emulsions and require the presence of an oil-in-water emulsifier.

2. Creams by composition are divided into hydrophobic (fat) and hydrophilic (emulsion). Hydrophobic creams are prepared on the basis of water-oil or oil-water-oil emulsion stabilized with suitable emulsifiers.

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  • Information updated : 09 / 07 / 2024
  • In stock
  • Manufacturer : 1 year for Classification of soft dosage forms

Model: Soft dosage forms

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Sticks are inserted into the urethra and other canals (cervix, ear canal, fistula and wound passages). They have the shape of a cylinder with a pointed end and a diameter of no more than 1 cm. The mass of the stick should be from 0.5 to 1 g.
7. Soft gelatin capsules are designed for liquid and paste-like drug substances and have a one-piece shell. They are spherical, ovoid, oblong or cylindrical in shape with hemispherical ends. There are three types of soft gelatin capsules, differing from each other in the relative hardness of the shell: soft (Capsulae gelatinosae molles), semi-soft (Perlac gelatinosae) and semi-hard (Capsulae gelatinosae durae elasticae). 8. Plasters by aggregate state can be solid and liquid. According to the degree of dispersibility, plaster masses can be alloys, solutions, suspensions, emulsions or combined systems. According to the composition of plaster masses plasters are divided into resin-wax, rubber, lead and liquid. Depending on the medical purpose and depth of therapeutic action plasters are epidermic, endermatic and dyadermatic. Epidermal patches in most cases do not contain drugs and are used mainly as a dressing material, to fix the surface of the skin bandages, convergence of wound edges, masking skin defects, protect it from various damaging factors of the environment. During the application of such a patch stops transpiration (evaporation through the skin), gas, moisture and heat exchange, resulting in softening of the skin, increasing regional blood circulation, improving the resorption of various infiltrates. These patches should be sufficiently sticky, tightly adhere to the skin and do not irritate it. Endermatic patches necessarily contain medicinal substances of different therapeutic action, such as keratolytic, depilatory and others. They are used to treat skin diseases at the site of the patch. Dyadermic patches contain medicinal substances that penetrate the skin and have a general therapeutic effect or affect subdermal tissues. Endermatic and diadermic patches are softer in consistency than epidermic patches and should provide the necessary effect of drugs, facilitating their penetration to a certain predetermined depth.

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Technical specifications

Hydrophobic creams use a fat base (lanolin, petroleum jelly, stearin) to which various active therapeutic substances such as vegetable oils, vitamins, hormones, fish oil and in some cases various aromatic substances or essential oils are added. The quality of a cream is not determined by its fragrance. In some cases, fragrance substances are added to creams to suppress the odor of the fat base.
Hydrophilic creams are prepared from an oil-water or water-oil-water emulsion stabilized with suitable emulsifiers. They also include colloidal dispersed systems consisting of higher fatty alcohols or acids dispersed in water or mixed water-glycol solvents, stabilized with hydrophilic surfactants.

3. Gels by type of dispersed systems are divided into hydrophobic and hydrophilic. Hydrophobic gels (oleogels) are prepared on bases of hydrophobic solvent (vaseline or vegetable oil, etc.) and lipophilic gelling agent (polyethylene, colloidal silicon dioxide, aluminum or zinc soap, etc.). Hydrophilic gels (hydrogels) are prepared on bases of water, hydrophilic mixed or non-aqueous solvent (glycerin, propylene glycol, ethyl alcohol) and hydrophilic gelling agent (carbomers, cellulose derivatives).

4. Pastes are a mixture of fats or fat-like compounds and various powdery substances. The basis of the paste may be lanolin, petroleum jelly, glycerin, linseed oil, olive oil and other vegetable oils, and more often ‘most often – their mixtures with each other. If the medicinal substances included in the paste are less than 25%, the missing amount is supplemented with indifferent powders such as starch, talc or zinc oxide. The pastes are used mainly for the treatment of affected wet skin areas as an anti-inflammatory drying agent and also in dentistry.
5. Liniments are liquid ointments. By the nature of the dispersed medium they are divided into the following groups: fat liniments, which as a dispersed medium contain fatty oils or fat-like substances (lanolin). The most commonly used are sunflower and linseed oil; alcohol liniments, which contain alcohol or tinctures (most often tincture of chilli pepper), as well as various medicinal substances; vasoliments, which are characterized by the presence of vaseline oil. Due to the high chemical inertness of vaseline oil, vasoliments show high stability during storage; soap-alcohol liniments (saponiments), as a dispersion medium they contain alcoholic solutions of soap.

Additional information

Saponiments can be liquid (if they contain potassium soap) or dense gel-like (if they contain sodium soap); liniments-solutions are transparent mixtures of fatty oils with essential oils, chloroform, methyl salicylate, ether, turpentine, which include various solid drugs soluble in prescribed solvents, such as camphor, menthol, anesthesin, etc.; liniments-suspensions are two-phase systems representing suspensions of powdery substances insoluble in prescribed liquids. ; liniments-suspensions are two-phase systems that are suspensions of powdery substances insoluble in prescribed liquids. Most often these liniments include zinc oxide, talc, xeroform, calcium carbonate, starch and sulfonamide preparations. As a dispersion medium, glycerin, fatty oils, alcohol, water, etc. are used. A classic example of a liniment-suspension is Vishnevsky liniment; liniments-emulsions are two-phase systems that can be water-oil or oil-water emulsion. They consist of a mixture of fatty oils with alkali or contain soap solutions. The advantages of liniments include their high biological activity, ease of application to the skin and rapid absorption. Disadvantages of liquid ointments are low stability of some of them and inconvenience of transportation.
6. Suppositories are general and localized. General action suppositories are designed for rapid absorption of active substances into the blood. Suppositories of local action are used mainly for the purpose of” local effect of the drug on a particular inflammatory process, to relieve pain, etc.
According to the place of application suppositories are divided into three groups: rectal (suppositories) – Suppositoria rectalia, vaginal – Suppositoria vaginalia and sticks – Bacilli.
Rectal suppositories are inserted into the rectum and are considered mainly as a medicinal form of general action. They are prescribed in disorders of cardiovascular activity, neuropsychiatric disorders, etc. Application in such cases is explained by the rapidity of the effect of the medicinal substances prescribed in the form of suppositories.
They can be in the form of a cone, cylinder with a pointed end or other shape with a maximum diameter of 1.5 cm. The mass of one suppository should be between 1 and 4 g. Vaginal suppositories are inserted into the vagina and used for local action. They can be spherical (balls) – globuli, ovoid” (ovuli) – ovula or in the form of a flat body with a rounded end (pessaries) – pessaria. The weight of suppositories should be within the range of 1.5 to 6 g.

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