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For non-long-acting tablets it is undesirable, because at therapeutic dosage of drugs slow release of the latter will not provide therapeutic concentration of them in the blood, so reducing the content of sliding substances by increasing their dispersibility allows to improve the quality of finished products. Lubricants facilitate the ejection of tablets from the matrix. They are also called adhesive or anti-adhesive agents. Lubricants not only reduce friction at the contact areas, but also greatly facilitate deformation of the particles due to adsorption reduction of their strength by penetrating into micro-cavities. The function of lubricants is to overcome the friction force between the granules and the matrix wall, between the compressed tablet and the matrix wall at the moment of tablet ejection from the matrix by the lower punch.
Pharmaceutical Glossary
Technical specifications
By their nature, sliding agents can be divided into two groups: fats and fat-like substances – paraffin, hydrogenated vegetable fats and cocoa butter, added in amounts up to 2%; calcium and magnesium stearates, pure stearic acid (< 1%); powdered substances – talc, starch and thein-80. Talc is added to the granulate no more than 3%, as it acts irritatingly on mucous membranes. Powdered substances are used more than fatty substances, because the latter affect the solubility and chemical stability of tablets. Powdered slip agents are introduced by powdering the granulate. Sliding agents have another function: to remove the electrostatic charge from the powder or phanulate particles, which also improves their flowability. Talc, stearates, aerosil are used for this purpose.
Additional information
Talc is one of the substances representing a type of lamellar silicates, which are based on layers of the densest hexagonal packing. The layers are bound together by residual van der Waals forces (the weakest of all chemical bonds). Due to this property and high dispersibility of particles they are capable of deformation and good sliding. It is advisable to introduce these substances into the composition of tabletting masses in a highly dispersed state. The greater the degree of refinement, the greater the surface area of the tabletting mass they can cover for the same amount. Since talc and stearates are hydrophobic sliding substances, they impede the penetration of digestive liquids into the porous structure of the tablet, which worsens its disintegration.
Order status tracking
I've been calling your office since this morning, and no one's picking up the phone. 22/07/2024 06:14
Good afternoon, Penelope! The office will be open from 9:00 GMT. We'll be in touch. 22/07/2024 06:16
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 22/07/2024 06:24
Good afternoon Noah, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. tomorrow until 16:30 we will get a reply from the manufacturer on the final time frame. 22/07/2024 06:25
RZW-29 rotary tablet press in USA. Regards, Liam. 22/07/2024 06:34
Liam, Delivery will be made after lunch to USA . Please have the movers ready. The weight of the equipment is heavy. 22/07/2024 06:36
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 22/07/2024 06:44
Good afternoon David, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. as agreed we will get a reply from the manufacturer on the final time frame. 22/07/2024 06:46
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled In the afternoon to open the box and test. 22/07/2024 06:54
Jayden, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 22/07/2024 06:57
Dear Roman, good afternoon, vacuum powder conveyors QV-05 in quantity of 4 pieces, already on their way to Valletta ? 22/07/2024 07:04
Good afternoon, Victoria! Our manager has sent a scan of the bill of lading to your email. The shipment is on its way. 22/07/2024 07:06
LW-35 automatic PVC+cardboard blister packaging machine has been on the road for 30 days. What news ? 22/07/2024 07:14
Hello Matthew, We are on time, tomorrow until 14:30 a driver will contact you about unloading. 22/07/2024 07:17
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 22/07/2024 07:24
Good afternoon Benjamin, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. as agreed we will get a reply from the manufacturer on the final time frame. 22/07/2024 07:24
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Antwerp. 22/07/2024 07:34
Hello Sofia, Delivery status checked, tomorrow until 16:30 is arriving at Antwerp . The driver will call you beforehand. 22/07/2024 07:37
HX-6 Plastic Tube Filling and Sealing Machine in Vatican City? Price delivery terms and conditions 22/07/2024 07:44
Samuel, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 22/07/2024 07:46
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR COATING TABLETS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS