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In such cases it is necessary to add substances with a higher cohesive force (solutions of starch, gelatine, etc.) and again it is necessary to resort to granulation in order to introduce binding agents into the tablet mass, which increase the plasticity of the drug substances; in this case the property called adhesion is manifested, which causes the adhesion of the particles to each other.
Disintegrability. The tablet should have the required disintegrability with adequate mechanical strength. Too high strength of the tablet affects its disintegration and release of the drug substance – disintegration time increases, which adversely affects the quality of the tablet. Disintegration depends on a number of reasons: on the amount of binding agents: tablets should contain as much of them as necessary to achieve the required strength; on the pressing pressure: excessive pressure worsens the disintegration of the tablet; on the quality of loosening agents that contribute to the disintegration of tablets; on the properties of the substances in the tablet, their ability to dissolve in water, wetting it, swelling; tablets with easily soluble substances will disintegrate faster and less loosening agents will be required.
The mass subjected to tabletting should have a set of properties that ensure the fulfillment of the above requirements: accuracy of dosing, mechanical strength and disintegration.
Pharmaceutical Glossary
Technical specifications
In these cases, antifriction agents are added to the material to reduce friction between the particles by giving them a smooth surface. In general, fine powders have poor sliding properties and tend to stick to the funnel surface, so it is necessary to artificially increase the particle size to an optimum value by granulating the material.
Delamination causes a change in the weight of the tablets. In some cases delamination can be prevented by installing a small agitator in the funnel, but a more radical measure is to equalize the particle size by granulating the material. When speaking of the homogeneity of a material, one also means its homogeneity in particle shape. Obviously, particles having different spatial outlines at approximately the same mass will be placed in the matrix nest with different compactness.
This circumstance will also cause variation in the mass of the tablets. Particle shape equalization is achieved by the granulation process. It should be noted that it is quite difficult to achieve homogeneity of granules, so by varying the ratio of fractions of granulate by experimentation, it is possible to establish the optimal composition that meets the best bulkiness and high quality of tablets at a certain pressing pressure.
Mechanical strength. Mechanical strength is determined by the interlocking of the particles. At the beginning of the pressing process, the tablet mass is compacted, the particles are brought closer together and conditions are created for the manifestation of intermolecular and electrostatic interaction forces.
Additional information
Intermolecular interaction forces are manifested when the particles approach each other at a distance of 10″6-10″7 cm. The pressing process of the tablet mass can be divided into three stages. The mechanical strength depends on the amount of pressure in the pressing process and it is important to trace the pressure increase during pressing. In impact tablet machines (eccentric) the pressure builds up sharply, as a result of which the surface of the tablet under the impact of the punches is strongly heated (mechanical energy is converted into thermal energy) and the substances fuse to form a continuous cementitious layer.
In rotary tabletting machines, the pressure builds up gradually, which gives better results, as it provides a longer exposure of the tabletting mass to pressure. The longer the exposure, the more completely the air will be removed from the tabletting mass, which after the pressure is removed, expanding, can have a destructive effect on the tablets. In addition, the heating of the tablet near the surface is significantly weakened, which eliminates the harmful effect of increased temperature on the substances that make up the tablet.
Application of high pressure during pressing can adversely affect the quality of tablets and contribute to the wear of tablet machines. High pressure can be compensated by addition of substances possessing a large dipole moment and providing adhesion of particles at relatively low pressures.
Water, having sufficient dipole moment, is a “bridge” between these particles. Water will prevent the binding of particles of difficult to dissolve and insoluble drugs.
Order status tracking
In Marburg ITA-01 tablet and capsule counter, RZ-9 rotary tablet press and manual capsule filling machine. Help when we get it ? 19/05/2024 07:16
Good afternoon, Liam! We have received from the factories photos of the equipment after packing. Natalia will forward the photos to you. Delivery time to you is 45-50 days. 19/05/2024 07:19
When purchasing the RY-200 centrifugal type powder granulator, I asked for tests on our powder 19/05/2024 07:26
Hello James, Please send 2 kg of your raw material to the address given to you by Natalia. After the test, the engineer will inform you about the results. 19/05/2024 07:29
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled the day after tomorrow to open the box and test. 19/05/2024 07:36
Hazel, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 19/05/2024 07:39
HX-6 Plastic Tube Filling and Sealing Machine in Zurich? Price delivery terms and conditions 19/05/2024 07:46
Samuel, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 19/05/2024 07:49
We have sent to info@minipress.ru photos of the damaged box with induction welding membrane machine FG-08. Please call back. 19/05/2024 07:56
Good day, Sophia! Damage to the packaging is unfortunately a common practice in transportation. Please carefully unpack the shipment and send us a series of photos. We will take a look and take action. 19/05/2024 07:59
PU-420 flow-pack packaging machine along with 500 kg packaging , delivery to St. Louis. Please confirm the delivery time. 19/05/2024 08:06
Good afternoon Amelia, your shipment has left. Arrival time in the morning. The driver will call you back later. Please organize prompt unloading. 19/05/2024 08:10
We're from New Jersey, we paid for the equipment on your invoice yesterday. Has the payment been received? How long will it take to deliver to us? 19/05/2024 08:16
Ethan, hello. Payment is credited to our settlement account. Term of manufacture of your equipment by the factory 20 working days, delivery from the factory to our warehouse in the USA 1 month, delivery from the warehouse in Colorado Springs 15 calendar days. 19/05/2024 08:20
Horizontal granulator for organic fertilizers JU-80, the price is up to date ? Delivery time to Budapest? Urgent. 19/05/2024 08:26
Joseph, Please read carefully the description of this model in our catalog. Prices are current. Timing 1-1.5 months. 19/05/2024 08:29
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Hum, but immediately upon arrival send it to Sofia. 19/05/2024 08:36
Hello Aurora, we will try to resolve this issue for you. 19/05/2024 08:40
Please inform me about the status of the order Rotary tablet press RZ-10A in Arlington ? 19/05/2024 08:46
Good afternoon, Lily. We have contacted the carrier, delivery is scheduled between 12:00-14:00. Please let us know when you receive it. Thank you. 19/05/2024 08:49
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR COATING TABLETS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- PERISTALTIC PUMPS DISPENSERS