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Phytosterol in its structure is close to cholesterol and has its properties: 1 part of phytosterol can hold up to 12 parts of water.’In appearance, phytosterol is a white creamy mass, which is easily applied to the skin, well tolerated and recommended for those with sensitive skin. A water base containing up to 15% phytosterol is used in ointments for the treatment of eczema.
Gels of clay minerals. Found application montmorillonite deposits of Ukraine. Sodium forms of montmorillonites are so finely dispersed that they are able to form a very delicate paste when mixed with water or aqueous solutions.
Bentonites are natural inorganic polymers. They are related to clay materials. Bentonites are able to form a film on the skin that dries quickly, so they are used in protective ointments. Bentonites (especially their sodium salts) have a high swelling capacity. They have high indifferentiability, stability, ability to absorb exudate. Bentonites easily release the drug substance, provide its absorption, and can be used to obtain dry ointments-concentrates. The disadvantage of bentonites is their drying. To prevent this, up to 10% glycerin is added to the base. Protein solutions and gels. Currently, gelatin, which is a product of denaturation of collagen protein of connective tissue, is used exclusively for the purpose of obtaining protective ointments. Collagen gels. Collagen is a bioadequate polymer and represents the main protein of connective tissue. It is obtained from the skin of cattle. At a concentration of 2-5% it forms viscous transparent gels when swelling in water. Optimal rheological properties have gels of collagen at a concentration of 3%. These gels are non-toxic, absorbed and fully utilized by the body, well release drugs, have sorption ability, reparative properties and are included in ointments for the treatment of wounds. The disadvantage of collagen gels is their susceptibility to drying. To prevent this, up to 2% glycerin is added to them.
Gelatin-glycerin gel (gelatin 1-3%, glycerin 10-30%) is a transparent mass of yellowish color, which easily liquefies when rubbed into the skin. It is used for making protective ointments and skin adhesives, as it solidifies on the skin in the form of a film. The gel is applied to the hands in the melted state.
Pharmaceutical Glossary
Technical specifications
The polymer consists of glucose and has a molecular weight of up to 150. Dextran solutions are colorless and odorless substances of ointment-like consistency with high indifference and a pH of 4.5 to 6.5. Starch gels. Starch-glycerin gel is used, which is a colorless transparent homogeneous mass. It is easily distributed on the surface of the mucous membrane. Due to the presence of glycerin, this gel is resistant to microorganisms, but during storage is subject to syneresis – spontaneous reduction in the volume of the gel, accompanied by the separation of liquid. Starch-glycerin gel is excluded from the State Register, but is used in pharmacy practice.
Solutions and gels of natural and synthetic polymers represent a large group of water-soluble ointment bases. Polyethylene glycol bases have found the widest application among polymers of this group, they are included in pharmacopoeias of most countries of the world. Polyethylene glycol bases for ointments can be: separate monomers obtained by polymerization of ethylene oxide and having elastically viscous plastic consistency; a mixture of liquid and solid monomers, sometimes with the addition of any fillers.
In addition, polyethylene glycols (PEGs), also called polyethylene oxides (PEOs), can be used to prepare absorption, emulsion and other bases.
Polyethylene oxides are the product of polymerization of ethylene oxide in the presence of alkali. There are differentiated volatile (PEO-400) and solid (PEO-1500, PEO-4000) polyethylene oxides. Their consistency depends on the degree of polymerization. PEO-400 and PEO-1500 alloys are used as bases for ointments. Optimal rheological properties have an alloy in the ratio of 8:12. These bases are indifferent, resistant to heat and light, do not disrupt the physiological functions of the skin, easily release drugs and ensure their high bioavailability. They have high osmotic activity and are used in ointments for the treatment of purulent wounds (levomikol, levosin, etc.). In addition, polyethylene oxides can be used for the preparation of absorbent, emulsion and other bases. The disadvantage of polyethylene oxides is that they cause dehydration of mucous membranes.
Additional information
Solutions of oligoesters. Oligoesters are esters of polyatomic alcohols (glycerol, sorbitol, diethylene glycol, etc.) and multibasic acids (tartaric, citric, succinic, etc.). Depending on the ratio of the initial components and the degree of their condensation, products of different viscosity can be obtained: from liquid to very thick.
Polyvinylpyrrolidone gels. Polyvinylpyrolidone (PVP) is a colorless amorphous hygroscopic powder, soluble in water, glycerol and polyethylene oxides. Aqueous solutions of PVP change color during storage and are subject to microbial contamination. PVP is miscible with lanolin, simple and esters, castor oil, cellulose derivatives and silicone fluids. PVP gel at concentrations up to 20% is used to prepare bases. Polyvinyl alcohol gels. Polyvinyl alcohol (PVS) is a white or yellowish powder, insoluble in ethyl alcohol. PVA is soluble in water and glycerin when heated. Aqueous solutions of PtHS are characterized by high viscosity. For ointments 15 % PVA gel is used.
Rarely cross-linked acrylic polymers (RAP) are copolymers of acrylic acid with polyalkyl polyethers of polyatomic alcohols. Abroad they are called “Carbopols” or “Carbomers”. In USA they are produced under the brand name “Arespol” or “MARS-06”. RAPs form viscous transparent homogeneous gels with maximum viscosity in the pH range from 5 to 9. They easily release drug substances and provide their high bioavailability. RAPs are absorbed through the skin and provide a prolonged effect.
Phytosterol gels. They are formed due to the ability of phytosterol to swell strongly in water, apparently due to the formation of H-bonds. Phytosterol is soluble in many organic solvents, but at the same time is able to retain significant amounts of water (12 times the initial mass of phytosterol). A gel consisting of 12-15% phytosterol and 88-85% water has been proposed as a base for ointments.
It is a white or slightly yellowish mass, which is mixed with amidochlorous mercury, zinc oxide, sulfur, ichthyol and other substances. Phytosterol is obtained from coniferous wood. The main component is B-sterol.
Order status tracking
Vacuum powder conveyor QV-01 quantity of 3 pieces, need discount and delivery to Dallas. 18/05/2024 05:02
Good day Lucas, in our catalog all prices are given including delivery to the door of the customer. If you buy 3 pieces we will make a discount of 7%. Delivery to Dallas is included in the price. 18/05/2024 05:02
Natalia tell me, automatic double-sided labeling machine ST-36 has left the factory, invoice #118. 18/05/2024 05:12
Hello Lila, The equipment has been shipped from the transit warehouse and delivery is proceeding as planned. No delays are expected. 18/05/2024 05:13
Vacuum powder conveyor QV-01 quantity of 3 pieces, need discount and delivery to Colorado Springs. 18/05/2024 05:22
Good day William, in our catalog all prices are given including delivery to the door of the customer. If you buy 3 pieces we will make a discount of 7%. Delivery to Colorado Springs is included in the price. 18/05/2024 05:25
Mixer with paddle for powders CX-100 what is the exact packing size ? 18/05/2024 05:32
Grace, Hello! Packing dimensions 1200x640x1000 mm, packing weight 250 kg. Please let me know when you receive the shipment. 18/05/2024 05:32
To what address to send you samples of bottles and caps to send them to the factory ? Regards Elizabeth. 18/05/2024 05:42
Good day, Elizabeth We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 18/05/2024 05:42
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 18/05/2024 05:52
Ethan, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Fresno ? Contact Natalia, she will send the contract and invoice. 18/05/2024 05:54
PU-250 flow-pack packaging machine, please advise delivery status. 18/05/2024 06:02
Hello Lucas, your equipment is undergoing customs clearance. Your manager Natalia will contact you tomorrow by lunchtime 18/05/2024 06:05
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 18/05/2024 06:12
Layla, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Miami ? Contact Natalia, she will send the contract and invoice. 18/05/2024 06:12
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 18/05/2024 06:22
Hello Daniel, Our manager Natalia in the interval from 14:00-16:00 will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Braila in 15 days. 18/05/2024 06:25
Horizontal granulator for organic fertilizers JU-80, the price is up to date ? Delivery time to York? Urgent. 18/05/2024 06:32
Nora, Please read carefully the description of this model in our catalog. Prices are current. Timing 1-1.5 months. 18/05/2024 06:35
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR COATING TABLETS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING