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As a result of the first four examples, the coated particles can be either compressed into tablets or placed in hard gelatin capsules. The drug substance-ion exchange resin complexes can be dispersed in viscous liquids to form liquid suspensions. It is important to recognize the fact that a sustained-release dosage form usually contains an extremely high amount of drug substance, which can cause problems if the initial dose is released quickly. This phenomenon is called “dose release” and can be eliminated if: the film coating is mechanically strong and moisture resistant; the application of the film to the material is uniform; and the drug substance is not chewed (crushed) before swallowing. Coatings providing delayed (delayed) release of the medicinal substance. When using dosage forms with delayed (delayed) release of a medicinal substance, the duration of action of the medicinal substance is increased by prolonging its release. As such a coating can be used a polymer brand Kollicoat SR 30D, the formulation of which consists of polyvinyl acetate (27%), KZO povidone (2.7%) and sodium lauryl sulfate (0.3%) as stabilizers and water (70%).
Kollicoat SR has good film-forming properties, swells easily in water, has pH-independent action and provides a strong stable delayed-release effect of the drug.
Pharmaceutical Glossary
Technical specifications
This type of coating is used in prolonged release dosage forms where an initial dose of a drug substance is released into the body and the remaining (maintenance) doses are released at a constant rate to ensure that the desired therapeutic concentration is maintained. Dosage forms with continuous, evenly prolonged release provide a sustaining effect of the drug substance. They are more effective than forms with periodic release, as they provide a constant concentration of drug in the body at the therapeutic level without pronounced extremes, do not overload the body with excessively high concentrations. Dosage forms using sustained-release coatings avoid the need for repeated administration of the drug into the body, especially for those medicine that require maintaining a constant concentration in the blood for a long period of time. In addition, sustained release is used for high-dose medicine, the rapid release of which causes undesirable side effects (e.g., ulcer formation with rapid release of potassium chloride in the GI tract). Methods of creating drug products with sustained release of the drug substance include: increasing the particle size of the drug substance; placing the drug substance in a matrix; coating the drug substance or a dosage form containing the drug substance; and forming complexes of the drug substance with materials such as ion exchange resins.
Additional information
Materials suitable for sustained-release coatings are: a mixture of waxes (e.g. beeswax) with glycerol monostearate, stearic acid, palmitic acid, glycerol monopalmitate and acetyl alcohol. They form polymers that dissolve slowly or degrade in the GI tract; shellac and zein, which do not degrade at low pH values; ethylcellulose, which forms a membrane around the dosage form that does not degrade in the GI tract. However, it is permeable to water, which dissolves the drug substance, as a result of which the latter diffuses into the GI tract; acrylic resins, the mechanism of action of which is similar to the action of ethylcellulose, i.e. there is a controlled diffusion of the drug substance through the coating; cellulose acetate (diacetate or triacetate); silicone elastomers. The development of sustained-release medicine using film coating technology can be accomplished by various methods, such as applying suitable film coatings to: dry granules (both heterogeneous and spheronized); microspheres containing the drug substance or coated with the drug substance; crystals of the drug substance; drug substance-ion exchange resin complexes; tablets (including minitabs).
Order status tracking
In St. Gallen ITA-01 tablet and capsule counter, RZ-9 rotary tablet press and manual capsule filling machine. Help when we get it ? 18/05/2024 18:06
Good afternoon, Mason! We have received from the factories photos of the equipment after packing. Natalia will forward the photos to you. Delivery time to you is 45-50 days. 18/05/2024 18:10
We received our order (BG-150 film coating boiler) in the box there was no spraying nozzle !!! 18/05/2024 18:16
Hello Bella, we checked with the factory. Your nozzle was not received in time for the shipment of the main machine. We will now deliver it to you by DHL express mail. 18/05/2024 18:18
Rotary tablet press RZK-25 I want to order with delivery to Berlin 18/05/2024 18:26
Good day, Ella We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 18/05/2024 18:27
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to Austin. Thank you. 18/05/2024 18:36
Harper, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to Austin is scheduled for tomorrow until 16:30. Please notify us upon receipt. 18/05/2024 18:39
RZW-29 rotary tablet press in Bruges. Regards, Nova. 18/05/2024 18:46
Nova, Delivery will be made tomorrow until 18: 30 to Bruges . Please have the movers ready. The weight of the equipment is heavy. 18/05/2024 18:47
Vacuum powder conveyor QV-01 quantity of 3 pieces, need discount and delivery to Pittsburgh. 18/05/2024 18:56
Good day Penelope, in our catalog all prices are given including delivery to the door of the customer. If you buy 3 pieces we will make a discount of 7%. Delivery to Pittsburgh is included in the price. 18/05/2024 18:57
Horizontal granulator for organic fertilizers JU-80, the price is up to date ? Delivery time to Luzern? Urgent. 18/05/2024 19:06
Aurora, Please read carefully the description of this model in our catalog. Prices are current. Timing 1-1.5 months. 18/05/2024 19:07
To what address to send you samples of bottles and caps to send them to the factory ? Regards Henry. 18/05/2024 19:16
Good day, Henry We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 18/05/2024 19:17
Granulator for wet granulation ZL-25 and Mixer V-shaped for powders VM-05 under contract No. 15 inform. 18/05/2024 19:26
Hello Owen, The shipment has arrived at the customs terminal, tomorrow by lunchtime is scheduled to be transferred to the transportation company. 18/05/2024 19:30
I've been calling your office since this morning, and no one's picking up the phone. 18/05/2024 19:36
Good afternoon, Aubrey! The office will be open from 9:00 GMT. We'll be in touch. 18/05/2024 19:40
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR COATING TABLETS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COATING TABLETS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER