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As a result of the first four examples, the coated particles can be either compressed into tablets or placed in hard gelatin capsules. The drug substance-ion exchange resin complexes can be dispersed in viscous liquids to form liquid suspensions. It is important to recognize the fact that a sustained-release dosage form usually contains an extremely high amount of drug substance, which can cause problems if the initial dose is released quickly. This phenomenon is called “dose release” and can be eliminated if: the film coating is mechanically strong and moisture resistant; the application of the film to the material is uniform; and the drug substance is not chewed (crushed) before swallowing. Coatings providing delayed (delayed) release of the medicinal substance. When using dosage forms with delayed (delayed) release of a medicinal substance, the duration of action of the medicinal substance is increased by prolonging its release. As such a coating can be used a polymer brand Kollicoat SR 30D, the formulation of which consists of polyvinyl acetate (27%), KZO povidone (2.7%) and sodium lauryl sulfate (0.3%) as stabilizers and water (70%).
Kollicoat SR has good film-forming properties, swells easily in water, has pH-independent action and provides a strong stable delayed-release effect of the drug.
Pharmaceutical Glossary
Technical specifications
This type of coating is used in prolonged release dosage forms where an initial dose of a drug substance is released into the body and the remaining (maintenance) doses are released at a constant rate to ensure that the desired therapeutic concentration is maintained. Dosage forms with continuous, evenly prolonged release provide a sustaining effect of the drug substance. They are more effective than forms with periodic release, as they provide a constant concentration of drug in the body at the therapeutic level without pronounced extremes, do not overload the body with excessively high concentrations. Dosage forms using sustained-release coatings avoid the need for repeated administration of the drug into the body, especially for those medicine that require maintaining a constant concentration in the blood for a long period of time. In addition, sustained release is used for high-dose medicine, the rapid release of which causes undesirable side effects (e.g., ulcer formation with rapid release of potassium chloride in the GI tract). Methods of creating drug products with sustained release of the drug substance include: increasing the particle size of the drug substance; placing the drug substance in a matrix; coating the drug substance or a dosage form containing the drug substance; and forming complexes of the drug substance with materials such as ion exchange resins.
Additional information
Materials suitable for sustained-release coatings are: a mixture of waxes (e.g. beeswax) with glycerol monostearate, stearic acid, palmitic acid, glycerol monopalmitate and acetyl alcohol. They form polymers that dissolve slowly or degrade in the GI tract; shellac and zein, which do not degrade at low pH values; ethylcellulose, which forms a membrane around the dosage form that does not degrade in the GI tract. However, it is permeable to water, which dissolves the drug substance, as a result of which the latter diffuses into the GI tract; acrylic resins, the mechanism of action of which is similar to the action of ethylcellulose, i.e. there is a controlled diffusion of the drug substance through the coating; cellulose acetate (diacetate or triacetate); silicone elastomers. The development of sustained-release medicine using film coating technology can be accomplished by various methods, such as applying suitable film coatings to: dry granules (both heterogeneous and spheronized); microspheres containing the drug substance or coated with the drug substance; crystals of the drug substance; drug substance-ion exchange resin complexes; tablets (including minitabs).
Order status tracking
YR-90 dry and wet powder granulator YR-90 month has already passed. Hurry up the factory. 24/08/2024 13:52
Lily, good afternoon. The factory has shipped your equipment to our representative, now is forming a consolidated shipment for shipment to customs. We will keep you informed. 24/08/2024 13:54
Natalia tell me, automatic double-sided labeling machine ST-36 has left the factory, invoice #118. 24/08/2024 14:02
Hello Mason, The equipment has been shipped from the transit warehouse and delivery is proceeding as planned. No delays are expected. 24/08/2024 14:04
Good day, tell me need delivery in Fresno to the settlement in the distance of 20 km. Can you organize this? 24/08/2024 14:12
David, Good afternoon, please send us an email to info@minipress.ru with the exact name of the equipment model, city, and your coordinates. We will calculate the delivery to you. 24/08/2024 14:15
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 24/08/2024 14:22
Ethan, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in San Jose ? Contact Natalia, she will send the contract and invoice. 24/08/2024 14:23
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled after lunch to open the box and test. 24/08/2024 14:32
Nova, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 24/08/2024 14:35
For shipping to Stockholm do you have to pay anything extra ? 24/08/2024 14:42
Good day Liam, In our catalog, all prices are inclusive of shipping to the customer's door. Delivery to Stockholm is included. 24/08/2024 14:42
Roman, our company bought VL-100 V-shaped powder mixer, but it is not enough for us, can we return it and exchange it for V-300 model? 24/08/2024 14:52
Hazel, good afternoon. When we corresponded with you, I warned you that this is a model with a small load. Unfortunately we can not pick up the equipment. As an option, we will offer our customers with a discount. 24/08/2024 14:54
Contract #12, the deadline for delivery has already passed. Take action at last. Accelerate Tsibulsky R.G. 24/08/2024 15:02
Hello Avery, we are on vacation on weekends and are not able to respond to messages. Raise the contract, delivery time of equipment to your warehouse in Edinburgh to 50 working ( not calendar) days. Action taken. 24/08/2024 15:03
Mixer with paddle for powders CX-100 what is the exact packing size ? 24/08/2024 15:12
Elizabeth, Hello! Packing dimensions 1200x640x1000 mm, packing weight 250 kg. Please let me know when you receive the shipment. 24/08/2024 15:15
Automatic blister packaging machine for PVC+cardboard LW-35 with delivery to Kansas City. We want to track the delivery status. 24/08/2024 15:22
Sebastian, hello. The shipment has already arrived. Now it is in the warehouse of the transportation company. Your manager will contact you to clarify the time of delivery to your city. 24/08/2024 15:24
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC CARTONING MACHINES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- PERISTALTIC PUMPS DISPENSERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS