Hydrophilic bases are mixed with water in any ratio. The following ointment bases are hydrophilic: solutions and gels of polysaccharides; solutions and gels of natural and synthetic polymers; phytosterol gels; gels of clay minerals; solutions and gels of proteins. The advantages of hydrophilic bases are: the possibility of introducing a significant amount of aqueous solutions...
One of the problems of tablet production is obtaining good granulate fluidity in feeding devices (funnels, bunkers). The resulting granules or powders have a rough surface, which makes it difficult for them to pour out of the loading funnel into the matrix sockets. In addition, the granules can stick to the walls of the die...
There are three ways of introducing medicinal substances into the suppository base, which are determined by the physico-chemical properties of the components: All water-soluble components are introduced in the form of aqueous solutions; fat-soluble substances are introduced in the form of fat solutions; substances insoluble in water and fats are introduced in the form of...
As noted earlier, the creation of effective medicines requires the use of a large number of excipients. Auxiliary substances in tablet production are intended to give the tablet mass the necessary technological properties that ensure: dosing accuracy, mechanical strength, disintegration, stability during storage. The effect of excipients on the effectiveness and quality of medicines, as...
The principal difference between the aerosol method and others is the presence of a gas dispersed medium and, as a consequence, with a significantly smaller size of interacting particles and formed microcapsules.
With small batch sizes (up to 800 liters) and/or frequent product changes, drying and cooling of granulates can also be carried out in a vertical granulator. During wet granulation, the powder is loaded into the granulator, then moistened or pollinated by melt. The tangential forces arising during the operation of the Z-shaped rotor blades ensure...
High-speed rotary tablet press. Modern rational design is the basis of excellent product quality. The integration of many years of experience in the production of high-speed tablet presses and modern science and technology has made it possible to standardize and launch a modular high-speed tablet press into mass production. High pressure. Big pills. Curly pills….
High-speed rotary tablet press. Modern rational design is the basis of excellent product quality. The integration of many years of experience in the production of high-speed tablet presses and modern science and technology has made it possible to standardize and launch a modular high-speed tablet press into mass production. High pressure. Big pills. Curly pills….
Wet granulation is subjected to powders having poor flowability and insufficient ability to bond between particles. In both cases, binding solutions are added to the mass, improving the adhesion between the particles. Granulation, or wiping of the wet mass, is carried out in order to compact the powder and obtain uniform grains — granules with...
The high-efficiency dry granulator is a new advanced model developed on the basis of the traditional of fluidized bed granulators. Not only convenience, reliability and safety have improved, but also the management of this equipment has become more accurate and efficient. As well as the design and scientific and technical content of the machines of this series…
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