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6759849
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In reality, there are no sharp boundaries between the three stages of pressing, as the processes occurring in the second stage take place in the first and third stages, and we can only speak about the predominant role of individual processes in each of the pressing stages. Studies have established that the nature of compaction of granules and powder particles during pressing depends on their strength. As mentioned in Sect. 4.4, tablets are produced by three methods: wet granulation, dry granulation and direct pressing.
Pharmaceutical Glossary
Technical specifications
In the second stage of pressing, as the pressing pressure increases, the material is intensively compacted by filling the voids and various types of deformation, which contribute to a more compact packing of the material. The resulting deformations can be of the following types: deformation due to elasticity helps the particles to wedge into each other, which increases the contact surface; deformation due to plastic properties makes the particles change their shape and fit more tightly together; deformation determined by the brittleness of the material, characterized by the destruction of the pressed material, occurs only when the stresses occurring in the pressed material exceed the yield strength of the material.
Additional information
In this case there is a mechanical destruction of material particles into smaller ones, accompanied by a significant increase in surface energy, which creates conditions for the emergence of contacts between particles. At the second stage of pressing a compact porous body with sufficient mechanical strength is formed from the bulk material. At the third stage of pressing at high pressure values, when the mechanical strength of tablets changes insignificantly, there is possibly a volumetric compression of powder particles and granules without a noticeable increase in contact surfaces.
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Roman Tsibulsky +79853643808
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Gabriel
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Antwerp. 22/02/2025 06:14
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Antwerp. 22/02/2025 06:14
Roman Tsibulsky
Hello Gabriel, Delivery status checked, tomorrow until 16:30 is arriving at Antwerp . The driver will call you beforehand. 22/02/2025 06:16
Hello Gabriel, Delivery status checked, tomorrow until 16:30 is arriving at Antwerp . The driver will call you beforehand. 22/02/2025 06:16
Mia
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Vatican City, then I want to buy an automatic capsule machine model GN-28 22/02/2025 06:24
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Vatican City, then I want to buy an automatic capsule machine model GN-28 22/02/2025 06:24
Roman Tsibulsky
Good afternoon, Mia! On the first question - the shipment will arrive in Vatican City tomorrow until 13:30. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 22/02/2025 06:25
Good afternoon, Mia! On the first question - the shipment will arrive in Vatican City tomorrow until 13:30. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 22/02/2025 06:25
Gabriel
Waiting for delivery to Lucca of a TR-02 hard gelatin capsule polishing machine. What about it? 22/02/2025 06:34
Waiting for delivery to Lucca of a TR-02 hard gelatin capsule polishing machine. What about it? 22/02/2025 06:34
Roman Tsibulsky
Hello Gabriel, on your order we inform you that in the interval from 14:00-16:00 the driver will contact you to clarify the time and place of unloading. 22/02/2025 06:36
Hello Gabriel, on your order we inform you that in the interval from 14:00-16:00 the driver will contact you to clarify the time and place of unloading. 22/02/2025 06:36
Emma
HX-6 Plastic Tube Filling and Sealing Machine in Valletta? Price delivery terms and conditions 22/02/2025 06:44
HX-6 Plastic Tube Filling and Sealing Machine in Valletta? Price delivery terms and conditions 22/02/2025 06:44
Roman Tsibulsky
Emma, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 22/02/2025 06:45
Emma, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 22/02/2025 06:45
Logan
YR-90 dry and wet powder granulator YR-90 month has already passed. Hurry up the factory. 22/02/2025 06:54
YR-90 dry and wet powder granulator YR-90 month has already passed. Hurry up the factory. 22/02/2025 06:54
Roman Tsibulsky
Logan, good afternoon. The factory has shipped your equipment to our representative, now is forming a consolidated shipment for shipment to customs. We will keep you informed. 22/02/2025 06:57
Logan, good afternoon. The factory has shipped your equipment to our representative, now is forming a consolidated shipment for shipment to customs. We will keep you informed. 22/02/2025 06:57
Emilia
Good afternoon, please confirm that in the morning we will receive our shipment in London? Contact the transportation company. 22/02/2025 07:04
Good afternoon, please confirm that in the morning we will receive our shipment in London? Contact the transportation company. 22/02/2025 07:04
Roman Tsibulsky
Hello Emilia ! Representatives of the transportation company on the delivery status of your shipment said that it will be in London in a few days. Please expect it. 22/02/2025 07:08
Hello Emilia ! Representatives of the transportation company on the delivery status of your shipment said that it will be in London in a few days. Please expect it. 22/02/2025 07:08
Hannah
I've been calling your office since this morning, and no one's picking up the phone. 22/02/2025 07:14
I've been calling your office since this morning, and no one's picking up the phone. 22/02/2025 07:14
Roman Tsibulsky
Good afternoon, Hannah! The office will be open from 9:00 GMT. We'll be in touch. 22/02/2025 07:14
Good afternoon, Hannah! The office will be open from 9:00 GMT. We'll be in touch. 22/02/2025 07:14
Alexander
Please inform me about the status of the order Rotary tablet press RZ-10A in Milwaukee ? 22/02/2025 07:24
Please inform me about the status of the order Rotary tablet press RZ-10A in Milwaukee ? 22/02/2025 07:24
Roman Tsibulsky
Good afternoon, Alexander. We have contacted the carrier, delivery is scheduled in the interval from 14:00-16:00. Please let us know when you receive it. Thank you. 22/02/2025 07:26
Good afternoon, Alexander. We have contacted the carrier, delivery is scheduled in the interval from 14:00-16:00. Please let us know when you receive it. Thank you. 22/02/2025 07:26
James
Dear Roman, good afternoon, vacuum powder conveyors QV-05 in quantity of 4 pieces, already on their way to Mariehamn ? 22/02/2025 07:34
Dear Roman, good afternoon, vacuum powder conveyors QV-05 in quantity of 4 pieces, already on their way to Mariehamn ? 22/02/2025 07:34
Roman Tsibulsky
Good afternoon, James! Our manager has sent a scan of the bill of lading to your email. The shipment is on its way. 22/02/2025 07:36
Good afternoon, James! Our manager has sent a scan of the bill of lading to your email. The shipment is on its way. 22/02/2025 07:36
Benjamin
I've been calling your office since this morning, and no one's picking up the phone. 22/02/2025 07:44
I've been calling your office since this morning, and no one's picking up the phone. 22/02/2025 07:44
Roman Tsibulsky
Good afternoon, Benjamin! The office will be open from 9:00 GMT. We'll be in touch. 22/02/2025 07:48
Good afternoon, Benjamin! The office will be open from 9:00 GMT. We'll be in touch. 22/02/2025 07:48
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- BOTTLE FILLING AND CAPPING EQUIPMENT
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- BOTTLE FILLING AND CAPPING EQUIPMENT
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR COATING TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER