СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Preparation of suppository base

Preparation of suppository base

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Preparation of suppository base

Preparation of suppository base

The stage of preparation of the suppository base begins with the sizing of its components. In the first stainless steel reactor with a steam jacket melt paraffin, in the second reactor melt hydrofat by supplying steam into the steam jacket. The heated hydrofat is transferred to the reactor with pre-melted paraffin by means of a pump. The mixture is heated to a temperature of 60-70 ° C and cocoa butter is added. In order to avoid changes in the modification of cocoa butter, heating should not exceed 70 ° C and be prolonged. After complete melting of the base it is stirred for 40 min with a stirrer. The melting point and the time of complete deformation are determined in the finished base.

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Information updated : 28 / 12 / 2025
In stock
Manufacturer : 1 year for Preparation of suppository base

Model: Suppository base

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Our service and customer service

The preparation of the suppository mass is carried out in a reactor, where the ready base is fed with compressed air and drug substances are added. As an example, the LT series reactor-mixer manufactured by the Italian company ZUMA s.r.l. is used. Mixers of this series are designed for the preparation of suppository mass, creams, ointments, etc. and are available in four sizes with the volume of the working tank 30, 60, 140 and 250 liters. The working tank of the reactor is a polished stainless steel tank with a water jacket for heating and melting of the mixture. The tank can be rotated by 90° for easy draining and washing. The agitator blades of the reactor are equipped with scraper blades. All working parts of the apparatus are made of stainless steel. The mixer reactor is equipped with safety guards and is manufactured according to international standard.

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Technical specifications

If the melting temperature of the base is higher or lower than the specified one, then paraffin or hydrofat is introduced into the base heated to 60-70 ° C with thorough mixing. The base is filtered through a druk-filter using a brass mesh or belting, analyzed by melting temperature, solidification and time of full deformation and transferred to the apparatus department.
Druk filters are pressurized capacitive filters. Druk-filters are vertical vessels (usually with a jacket) with an elliptical bottom.
The vessel filter housing can be open or closed. The upper part of the housing is fed with the slurry to be separated. The filtrate is discharged from the lower part. During filtration, compressed gas is fed into the slurry-filled housing.

Additional information

The filter baffle is located on the false bottom. The resulting sludge is washed, dried and discharged by means of an agitator through a hatch located on the side of the housing or in the center of the false bottom. In some designs, the sludge is removed after lowering the false bottom by moving the filter cloth belt, which passes through the regeneration chamber at the end of the sludge discharge. Druk filters are known, the body of which can be rotated by 90-180° in the trunnions fixed on its cylindrical part. Druk filters are used to separate medium and well-filtered suspensions in medium and low-tonnage productions.

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Riley
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 02/01/2026 02:36

Roman Tsibulsky
Riley, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer as stipulated in the contract. We will report back immediately. 02/01/2026 02:37

Owen
Remember me? There's a delivery in the Madrid 02/01/2026 02:46

Roman Tsibulsky
Owen, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be tomorrow until 15:30 in Madrid . 02/01/2026 02:49

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Roman Tsibulsky
Hello Sophia, Our manager Natalia in the morning will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Sigisoara in 15 days. 02/01/2026 03:06

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Good afternoon! semi-automatic liquid filling machine in barrels DF-13 , a copy of the payment is sent to the post. Start the order to work. 02/01/2026 03:16

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Lucy, good afternoon! We have seen your payment, we receive SMS from the bank. Please send drawings of barrels and answers to our questions in correspondence. 02/01/2026 03:16

Liam
HX-6 Plastic Tube Filling and Sealing Machine in Dubrovnik? Price delivery terms and conditions 02/01/2026 03:26

Roman Tsibulsky
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Rotary tablet press RZK-25 I want to order with delivery to Berlin 02/01/2026 03:36

Roman Tsibulsky
Good day, Lily We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 02/01/2026 03:36

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Hello Roman! Thank you for the service and quality of your products. We are very happy and satisfied with the purchase! 02/01/2026 03:46

Roman Tsibulsky
Hello Isabella, Apparently you have tested your vacuum lyophilic dryer LZY-01. Its quality is above average, it will work. We are waiting for your new applications. 02/01/2026 03:47

Chloe
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Roman Tsibulsky
Good afternoon, Ella, My WhastApp is +79853643808, Manager Natalia +79153808881 during business hours and except weekends. 02/01/2026 04:08