СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / GRANULATION PROCESS IN TABLET PRODUCTION / Binders for wet granulation

Binders for wet granulation

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / GRANULATION PROCESS IN TABLET PRODUCTION / Binders for wet granulation

Binders for wet granulation

There are some requirements for the granulating liquid, one of them is that the granulating liquid must not dissolve the active ingredient. Water, aqueous ethanol solution, acetone and methylene chloride can be used as granulating liquid. A wide range of substances are used as binders for wet granulation in modern pharmaceutical production, for example: starch (5-15 % g/g), starch derivatives, cellulose derivatives, which improve the plasticity of granules, as well as gelatin (1-3 % g/g) and PVP (3-10 % g/g). The most common and effective wet granulation binder in the modern pharmaceutical industry is a synthetic polymer such as Collidon (PVP), the various grades of which (Collidon 25, 30 and 90F) are widely available on the market.

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Information updated: 07 / 09 / 2026
Available for
Production: 1 year на оборудование для влажной грануляции

Model: Wet granulation

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Equipment leasing with advance payment from 10%

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Our service and customer service

Plasdon polymers have excellent bonding ability, good film forming properties, surfactant properties and high solubility in water and many solvents used in pharmaceutical applications. Due to this combination of properties, these polymers are widely used in a number of pharmaceuticals. Plasdone polymers have long been used as binding agents in wet granulation. Plasdone®S-630 Copovidone is a synthetic 60:40 linear polymer of N-vinyl-2 pyrrolidone and vinyl acetate. With its unique properties, Plasdone S-630 is well suited as a tablet binder for direct pressing and dry granulation applications, as well as a wet granulation binder.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

The granules obtained with PVP are hard, easy to bulk, forming harder tablets with low brittleness. PVP polymer improves the solubility of the active ingredient by forming complexes. In addition, PVP acts as a crystallization inhibitor. The regularities presented below were identified by BASF’s fine chemistry department. They are discussed using Collidon as an example. Wet granulation using Collidon 25, Collidon 30 and Collidon 90F generally results in a harder granular material with better bulk properties than other binders – less abrasion and higher bond strength. The polymer content of the granulating fluid used can vary from Collidon 25 – 2-5%; Collidon 30 – 2-5%; Collidon 90F – 1-3%.

Additional information

Thus, BASF’s research showed that Collidon 90F produced the highest tablet hardness at the same pressing pressure. All binders were used in the amount of 3%. Based on the data presented, it can be concluded that the increased hardness and reduced brittleness of calcium phosphate tablets when Collidon 30 is used as a binder in the wet granulation process. In addition to Collidon, there are a large number of substances used as binders in the pharmaceutical industry. Let us consider two of them. PlasdonPPovidone is a series of synthetic water-soluble homopolymers of N-vinyl-2 pyrrolidone.

Order status tracking

Roman Tsibulsky +79853643808 now online

Sophia
Natalia tell me, automatic double-sided labeling machine ST-36 has left the factory, invoice #118. 10/09/2026 04:08

Roman Tsibulsky
Hello Sophia, The equipment has been shipped from the transit warehouse and delivery is proceeding as planned. No delays are expected. 10/09/2026 04:09

Benjamin
Can your technician come to Oslo? We need technologist consultation and assistance. 10/09/2026 04:18

Roman Tsibulsky
Benjamin, We have already received your email. A technician in the interval from 14:00-16:00 will contact you. Don't worry. 10/09/2026 04:19

Joseph
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Tallinn, then I want to buy an automatic capsule machine model GN-28 10/09/2026 04:28

Roman Tsibulsky
Good afternoon, Joseph! On the first question - the shipment will arrive in Tallinn the day after tomorrow. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 10/09/2026 04:29

Zoey
Granulator for wet granulation ZL-25 and Mixer V-shaped for powders VM-05 under contract No. 15 inform. 10/09/2026 04:38

Roman Tsibulsky
Hello Zoey, The shipment has arrived at the customs terminal, tomorrow by lunchtime is scheduled to be transferred to the transportation company. 10/09/2026 04:41

Lucas
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 10/09/2026 04:48

Roman Tsibulsky
Lucas, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer tomorrow by lunchtime. We will report back immediately. 10/09/2026 04:49

Matthew
Good afternoon, please confirm that as agreed we will receive our shipment in Liverpool? Contact the transportation company. 10/09/2026 04:58

Roman Tsibulsky
Hello Matthew ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Liverpool in a few days. Please expect it. 10/09/2026 04:59

Lila
Good afternoon, please confirm that tomorrow until 17:30 we will receive our shipment in Monte Carlo? Contact the transportation company. 10/09/2026 05:08

Roman Tsibulsky
Hello Lila ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Monte Carlo in a few days. Please expect it. 10/09/2026 05:11

Mia
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 10/09/2026 05:18

Roman Tsibulsky
Mia, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Omaha ? Contact Natalia, she will send the contract and invoice. 10/09/2026 05:19

John
Waiting for delivery to Geneva of a TR-02 hard gelatin capsule polishing machine. What about it? 10/09/2026 05:28

Roman Tsibulsky
Hello John, on your order we inform you that closer to evening the driver will contact you to clarify the time and place of unloading. 10/09/2026 05:32

Grace
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Edinburgh ? 10/09/2026 05:38

Roman Tsibulsky
Hello Grace, Expect between 16:00-18:00. Once received, please let us know. 10/09/2026 05:40