СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / GRANULATION PROCESS IN TABLET PRODUCTION / Binders for wet granulation

Binders for wet granulation

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / GRANULATION PROCESS IN TABLET PRODUCTION / Binders for wet granulation

Binders for wet granulation

There are some requirements for the granulating liquid, one of them is that the granulating liquid must not dissolve the active ingredient. Water, aqueous ethanol solution, acetone and methylene chloride can be used as granulating liquid. A wide range of substances are used as binders for wet granulation in modern pharmaceutical production, for example: starch (5-15 % g/g), starch derivatives, cellulose derivatives, which improve the plasticity of granules, as well as gelatin (1-3 % g/g) and PVP (3-10 % g/g). The most common and effective wet granulation binder in the modern pharmaceutical industry is a synthetic polymer such as Collidon (PVP), the various grades of which (Collidon 25, 30 and 90F) are widely available on the market.

Whatever your challenge, MINIPRESS is ready to take it on. We are more powerful than many competitors and our service is much more convenient. We provide customers with impressive terms and amazingly fast turnaround times. Our specialists use the most advanced technologies in the world to select various equipment. We have everything you need for modern production of any level. And even more.

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Information updated: 11 / 07 / 2026
Available for
Production: 1 year на оборудование для влажной грануляции

Model: Wet granulation

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Equipment leasing with advance payment from 10%

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Our service and customer service

Plasdon polymers have excellent bonding ability, good film forming properties, surfactant properties and high solubility in water and many solvents used in pharmaceutical applications. Due to this combination of properties, these polymers are widely used in a number of pharmaceuticals. Plasdone polymers have long been used as binding agents in wet granulation. Plasdone®S-630 Copovidone is a synthetic 60:40 linear polymer of N-vinyl-2 pyrrolidone and vinyl acetate. With its unique properties, Plasdone S-630 is well suited as a tablet binder for direct pressing and dry granulation applications, as well as a wet granulation binder.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

The granules obtained with PVP are hard, easy to bulk, forming harder tablets with low brittleness. PVP polymer improves the solubility of the active ingredient by forming complexes. In addition, PVP acts as a crystallization inhibitor. The regularities presented below were identified by BASF’s fine chemistry department. They are discussed using Collidon as an example. Wet granulation using Collidon 25, Collidon 30 and Collidon 90F generally results in a harder granular material with better bulk properties than other binders – less abrasion and higher bond strength. The polymer content of the granulating fluid used can vary from Collidon 25 – 2-5%; Collidon 30 – 2-5%; Collidon 90F – 1-3%.

Additional information

Thus, BASF’s research showed that Collidon 90F produced the highest tablet hardness at the same pressing pressure. All binders were used in the amount of 3%. Based on the data presented, it can be concluded that the increased hardness and reduced brittleness of calcium phosphate tablets when Collidon 30 is used as a binder in the wet granulation process. In addition to Collidon, there are a large number of substances used as binders in the pharmaceutical industry. Let us consider two of them. PlasdonPPovidone is a series of synthetic water-soluble homopolymers of N-vinyl-2 pyrrolidone.

Order status tracking

Roman Tsibulsky +79853643808 now online

Chloe
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to London, do you deliver to the terminal or to the actual address? 31/07/2026 02:01

Roman Tsibulsky
Hello Chloe, we ship all over Europe and the US including to London . The price in the catalog includes any delivery our customer asks for. 31/07/2026 02:03

Sofia
Dear Roman, good afternoon, vacuum powder conveyors QV-05 in quantity of 4 pieces, already on their way to Oxford ? 31/07/2026 02:11

Roman Tsibulsky
Good afternoon, Sofia! Our manager has sent a scan of the bill of lading to your email. The shipment is on its way. 31/07/2026 02:13

Joseph
Rotary tablet press RZK-25 I want to order with delivery to Berlin 31/07/2026 02:21

Roman Tsibulsky
Good day, Joseph We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 31/07/2026 02:21

Bella
Contract #12, the deadline for delivery has already passed. Take action at last. Accelerate Tsibulsky R.G. 31/07/2026 02:31

Roman Tsibulsky
Hello Bella, we are on vacation on weekends and are not able to respond to messages. Raise the contract, delivery time of equipment to your warehouse in Crete to 50 working ( not calendar) days. Action taken. 31/07/2026 02:33

Aurora
Good afternoon, please confirm that after lunch we will receive our shipment in Zagreb? Contact the transportation company. 31/07/2026 02:41

Roman Tsibulsky
Hello Aurora ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Zagreb in a few days. Please expect it. 31/07/2026 02:44

Samuel
PU-250 flow-pack packaging machine, please advise delivery status. 31/07/2026 02:51

Roman Tsibulsky
Hello Samuel, your equipment is undergoing customs clearance. Your manager Natalia will contact you closer to evening 31/07/2026 02:55

Elijah
When purchasing the RY-200 centrifugal type powder granulator, I asked for tests on our powder 31/07/2026 03:01

Roman Tsibulsky
Hello Elijah, Please send 2 kg of your raw material to the address given to you by Natalia. After the test, the engineer will inform you about the results. 31/07/2026 03:03

Matthew
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 31/07/2026 03:11

Roman Tsibulsky
Matthew, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Detroit ? Contact Natalia, she will send the contract and invoice. 31/07/2026 03:15

Logan
Good afternoon, I am hoping tomorrow by lunchtime to get the UNIC 600A Tablet Press in Cambridge ! Please comment. 31/07/2026 03:21

Roman Tsibulsky
Good day, Logan! Our manager has communicated with the delivery service, the equipment will be delivered to Cambridge at your address. Please let us know when you receive it. 31/07/2026 03:24

Aiden
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled as agreed to open the box and test. 31/07/2026 03:31

Roman Tsibulsky
Aiden, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 31/07/2026 03:34