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In such cases it is necessary to add substances with a higher cohesive force (solutions of starch, gelatine, etc.) and again it is necessary to resort to granulation in order to introduce binding agents into the tablet mass, which increase the plasticity of the drug substances; in this case the property called adhesion is manifested, which causes the adhesion of the particles to each other.
Disintegrability. The tablet should have the required disintegrability with adequate mechanical strength. Too high strength of the tablet affects its disintegration and release of the drug substance – disintegration time increases, which adversely affects the quality of the tablet. Disintegration depends on a number of reasons: on the amount of binding agents: tablets should contain as much of them as necessary to achieve the required strength; on the pressing pressure: excessive pressure worsens the disintegration of the tablet; on the quality of loosening agents that contribute to the disintegration of tablets; on the properties of the substances in the tablet, their ability to dissolve in water, wetting it, swelling; tablets with easily soluble substances will disintegrate faster and less loosening agents will be required.
The mass subjected to tabletting should have a set of properties that ensure the fulfillment of the above requirements: accuracy of dosing, mechanical strength and disintegration.
Pharmaceutical Glossary
Technical specifications
In these cases, antifriction agents are added to the material to reduce friction between the particles by giving them a smooth surface. In general, fine powders have poor sliding properties and tend to stick to the funnel surface, so it is necessary to artificially increase the particle size to an optimum value by granulating the material.
Delamination causes a change in the weight of the tablets. In some cases delamination can be prevented by installing a small agitator in the funnel, but a more radical measure is to equalize the particle size by granulating the material. When speaking of the homogeneity of a material, one also means its homogeneity in particle shape. Obviously, particles having different spatial outlines at approximately the same mass will be placed in the matrix nest with different compactness.
This circumstance will also cause variation in the mass of the tablets. Particle shape equalization is achieved by the granulation process. It should be noted that it is quite difficult to achieve homogeneity of granules, so by varying the ratio of fractions of granulate by experimentation, it is possible to establish the optimal composition that meets the best bulkiness and high quality of tablets at a certain pressing pressure.
Mechanical strength. Mechanical strength is determined by the interlocking of the particles. At the beginning of the pressing process, the tablet mass is compacted, the particles are brought closer together and conditions are created for the manifestation of intermolecular and electrostatic interaction forces.
Additional information
Intermolecular interaction forces are manifested when the particles approach each other at a distance of 10″6-10″7 cm. The pressing process of the tablet mass can be divided into three stages. The mechanical strength depends on the amount of pressure in the pressing process and it is important to trace the pressure increase during pressing. In impact tablet machines (eccentric) the pressure builds up sharply, as a result of which the surface of the tablet under the impact of the punches is strongly heated (mechanical energy is converted into thermal energy) and the substances fuse to form a continuous cementitious layer.
In rotary tabletting machines, the pressure builds up gradually, which gives better results, as it provides a longer exposure of the tabletting mass to pressure. The longer the exposure, the more completely the air will be removed from the tabletting mass, which after the pressure is removed, expanding, can have a destructive effect on the tablets. In addition, the heating of the tablet near the surface is significantly weakened, which eliminates the harmful effect of increased temperature on the substances that make up the tablet.
Application of high pressure during pressing can adversely affect the quality of tablets and contribute to the wear of tablet machines. High pressure can be compensated by addition of substances possessing a large dipole moment and providing adhesion of particles at relatively low pressures.
Water, having sufficient dipole moment, is a “bridge” between these particles. Water will prevent the binding of particles of difficult to dissolve and insoluble drugs.
Order status tracking
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Tallinn, do you deliver to the terminal or to the actual address? 22/07/2024 06:09
Hello Scarlett, we ship all over Europe and the US including to Tallinn . The price in the catalog includes any delivery our customer asks for. 22/07/2024 06:10
Remember me? There's a delivery in the Dublin 22/07/2024 06:19
Oliver, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be tomorrow until 12:30 in Dublin . 22/07/2024 06:22
Can your technician come to Salzburg? We need technologist consultation and assistance. 22/07/2024 06:29
Daniel, We have already received your email. A technician in the interval from 14:00-16:00 will contact you. Don't worry. 22/07/2024 06:30
We received our order (BG-150 film coating boiler) in the box there was no spraying nozzle !!! 22/07/2024 06:39
Hello Michael, we checked with the factory. Your nozzle was not received in time for the shipment of the main machine. We will now deliver it to you by DHL express mail. 22/07/2024 06:40
YR-90 dry and wet powder granulator YR-90 month has already passed. Hurry up the factory. 22/07/2024 06:49
Oliver, good afternoon. The factory has shipped your equipment to our representative, now is forming a consolidated shipment for shipment to customs. We will keep you informed. 22/07/2024 06:53
Hello, is it possible to buy your blistering machine for tablets and capsules MN-80 1 piece with delivery to Cleveland ( Europe) ? How much time for delivery ? 22/07/2024 06:59
Daniel, hello! We have many customers from your city. Delivery to this region is made by EMC. 22/07/2024 07:02
I've been calling your office since this morning, and no one's picking up the phone. 22/07/2024 07:09
Good afternoon, Daniel! The office will be open from 9:00 GMT. We'll be in touch. 22/07/2024 07:09
Hello, is it possible to buy your blistering machine for tablets and capsules MN-80 1 piece with delivery to Cleveland ( Europe) ? How much time for delivery ? 22/07/2024 07:19
Logan, hello! We have many customers from your city. Delivery to this region is made by EMC. 22/07/2024 07:21
We're from New Jersey, we paid for the equipment on your invoice yesterday. Has the payment been received? How long will it take to deliver to us? 22/07/2024 07:29
Jackson, hello. Payment is credited to our settlement account. Term of manufacture of your equipment by the factory 20 working days, delivery from the factory to our warehouse in the USA 1 month, delivery from the warehouse in New Orleans 15 calendar days. 22/07/2024 07:33
Good day, delivery time of semi-automatic drum filling machine DF-10 to Warsaw, will the courier call us? 22/07/2024 07:39
Joseph, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 22/07/2024 07:40
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR COATING TABLETS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- PERISTALTIC PUMPS DISPENSERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR MIXING POWDERS