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The disadvantages of spray drying method include contact of thermolabile material with hot drying agent, complexity and high cost of equipment for liquid dispersion and dust collection.
Spray drying has a well-established technology, but traditional spray drying produces only microparticles. Recently, new Techniques and improved equipment are being developed to carry out the spray drying process, the aim of which is to obtain nanosized particles.
For this purpose, the following two conditions must be met: reduce the initial droplet size; use solutions with low solid phase content. It is possible to reduce the droplet size by using new atomizing devices, such as ultrasonic atomizing devices that achieve droplet sizes of 3 µm and below, or electrospray, which gives even smaller droplets. The second condition, low solids content in the solution, ensures that the initial droplet size decreases significantly as the solution is dewatered, yielding nanometer-sized particles. For example, when drying an aqueous solution with solid phase concentration not more than 7 % and initial droplet size of 1.5 microns, it is possible to obtain particles of 100 nm.
Pharmaceutical Glossary
Technical specifications
The fluid supply is pressurized. The nozzle delivers the fluid continuously or intermittently. There are many ways to atomize the liquid.
The choice of type of atomizing device and its design are determined by the properties of the atomized liquid, the need to obtain a homogeneous atomizing plume of a certain dispersion, the required productivity, the degree of complexity of construction and maintenance, as well as the cost. The main indicators of nozzles are atomization rate of liquid, macrostructure (angle and length of the jet; spatial distribution of droplets) and microstructure (size of droplets and their size distribution). The principle of operation of a pneumatic nozzle is based on the fact that compressed air breaks the solution into individual small particles, which is ejected from the nozzle of the nozzle at high velocity and dispersed torch. The position of the nozzle during atomization can be adjusted. Spray dryers operate on the principle of direct current, counter current and mixed current. Design design of spray drying plants is determined by technological requirements (type of product, its thermal lability, viscosity of the liquid, etc.), type of atomizing device, capacity for evaporated moisture and other parameters. Cyclones 6 are used to clean the exhaust air sucked from the tower by the fan. Pumps inject material and air into the pneumatic nozzle (atomization is made in counterflow of the drying agent).
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Additional information
The process scheme is as follows: the solution or suspension to be dried is fed through a pneumatic nozzle into the drying chamber. The atomization process produces a large number of polydisperse droplets. The atomized particles have a large surface area, which results in intensive heat and mass transfer with the drying agent entering the chamber through the nozzle. They quickly lose moisture and in a few seconds spherical porous granules are formed from the suspended suspension of dewatered droplets, which fall to the bottom of the chamber and fall into a container for product collection. The granules have good friability and compressibility, so tablets produced from such granulate have high strength and compressibility at low pressures. Single-section, unidirectional (direct flow of suspension droplets relative to the coolant flow) dryers are also used in the spray granulation process, which will be discussed in the next section.
The specificity of the process determines a number of characteristic advantages of the spray drying method: high quality of the dry product; high intensity of heat and mass transfer between the dispersed material and the heat transfer gas, determined by the degree of dispersibility of the material, gas temperature and hydrodynamic features of the apparatus; possibility of process control; continuity of drying.
Order status tracking
Horizontal granulator for organic fertilizers JU-80, the price is up to date ? Delivery time to Salzburg? Urgent. 14/05/2025 20:56
Oliver, Please read carefully the description of this model in our catalog. Prices are current. Timing 1-1.5 months. 14/05/2025 20:59
RZW-29 rotary tablet press in Valletta. Regards, Lucy. 14/05/2025 21:06
Lucy, Delivery will be made between 12:00-14:00 to Valletta . Please have the movers ready. The weight of the equipment is heavy. 14/05/2025 21:08
HX-6 Plastic Tube Filling and Sealing Machine in Istanbul? Price delivery terms and conditions 14/05/2025 21:16
Lucas, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 14/05/2025 21:19
Please inform me about the status of the order Rotary tablet press RZ-10A in Phoenix ? 14/05/2025 21:26
Good afternoon, James. We have contacted the carrier, delivery is scheduled tomorrow until 18: 30. Please let us know when you receive it. Thank you. 14/05/2025 21:29
Hello Roman! Thank you for the service and quality of your products. We are very happy and satisfied with the purchase! 14/05/2025 21:36
Hello Logan, Apparently you have tested your vacuum lyophilic dryer LZY-01. Its quality is above average, it will work. We are waiting for your new applications. 14/05/2025 21:38
Dear Roman, good afternoon, vacuum powder conveyors QV-05 in quantity of 4 pieces, already on their way to Antwerp ? 14/05/2025 21:46
Good afternoon, Ethan! Our manager has sent a scan of the bill of lading to your email. The shipment is on its way. 14/05/2025 21:47
Vacuum powder conveyor QV-01 quantity of 3 pieces, need discount and delivery to New Orleans. 14/05/2025 21:56
Good day Samuel, in our catalog all prices are given including delivery to the door of the customer. If you buy 3 pieces we will make a discount of 7%. Delivery to New Orleans is included in the price. 14/05/2025 21:57
We have sent to info@minipress.ru photos of the damaged box with induction welding membrane machine FG-08. Please call back. 14/05/2025 22:06
Good day, Olivia! Damage to the packaging is unfortunately a common practice in transportation. Please carefully unpack the shipment and send us a series of photos. We will take a look and take action. 14/05/2025 22:09
LW-35 automatic PVC+cardboard blister packaging machine has been on the road for 30 days. What news ? 14/05/2025 22:16
Hello William, We are on time, in the morning a driver will contact you about unloading. 14/05/2025 22:18
Good day, I want tomorrow until 17:30 to get FF-02 tablet and capsule filling machine in Reykjavik? 14/05/2025 22:26
Good afternoon, William! We have contacted the transportation company, your shipment is arriving in Reykjavik without delay. Please wait for a call from a representative of Business Lines. 14/05/2025 22:27
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- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- PERISTALTIC PUMPS DISPENSERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER