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The disadvantages of spray drying method include contact of thermolabile material with hot drying agent, complexity and high cost of equipment for liquid dispersion and dust collection.
Spray drying has a well-established technology, but traditional spray drying produces only microparticles. Recently, new Techniques and improved equipment are being developed to carry out the spray drying process, the aim of which is to obtain nanosized particles.
For this purpose, the following two conditions must be met: reduce the initial droplet size; use solutions with low solid phase content. It is possible to reduce the droplet size by using new atomizing devices, such as ultrasonic atomizing devices that achieve droplet sizes of 3 µm and below, or electrospray, which gives even smaller droplets. The second condition, low solids content in the solution, ensures that the initial droplet size decreases significantly as the solution is dewatered, yielding nanometer-sized particles. For example, when drying an aqueous solution with solid phase concentration not more than 7 % and initial droplet size of 1.5 microns, it is possible to obtain particles of 100 nm.
Pharmaceutical Glossary
Technical specifications
The fluid supply is pressurized. The nozzle delivers the fluid continuously or intermittently. There are many ways to atomize the liquid.
The choice of type of atomizing device and its design are determined by the properties of the atomized liquid, the need to obtain a homogeneous atomizing plume of a certain dispersion, the required productivity, the degree of complexity of construction and maintenance, as well as the cost. The main indicators of nozzles are atomization rate of liquid, macrostructure (angle and length of the jet; spatial distribution of droplets) and microstructure (size of droplets and their size distribution). The principle of operation of a pneumatic nozzle is based on the fact that compressed air breaks the solution into individual small particles, which is ejected from the nozzle of the nozzle at high velocity and dispersed torch. The position of the nozzle during atomization can be adjusted. Spray dryers operate on the principle of direct current, counter current and mixed current. Design design of spray drying plants is determined by technological requirements (type of product, its thermal lability, viscosity of the liquid, etc.), type of atomizing device, capacity for evaporated moisture and other parameters. Cyclones 6 are used to clean the exhaust air sucked from the tower by the fan. Pumps inject material and air into the pneumatic nozzle (atomization is made in counterflow of the drying agent).
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Additional information
The process scheme is as follows: the solution or suspension to be dried is fed through a pneumatic nozzle into the drying chamber. The atomization process produces a large number of polydisperse droplets. The atomized particles have a large surface area, which results in intensive heat and mass transfer with the drying agent entering the chamber through the nozzle. They quickly lose moisture and in a few seconds spherical porous granules are formed from the suspended suspension of dewatered droplets, which fall to the bottom of the chamber and fall into a container for product collection. The granules have good friability and compressibility, so tablets produced from such granulate have high strength and compressibility at low pressures. Single-section, unidirectional (direct flow of suspension droplets relative to the coolant flow) dryers are also used in the spray granulation process, which will be discussed in the next section.
The specificity of the process determines a number of characteristic advantages of the spray drying method: high quality of the dry product; high intensity of heat and mass transfer between the dispersed material and the heat transfer gas, determined by the degree of dispersibility of the material, gas temperature and hydrodynamic features of the apparatus; possibility of process control; continuity of drying.
Order status tracking
Contract #12, the deadline for delivery has already passed. Take action at last. Accelerate Tsibulsky R.G. 22/07/2024 06:20
Hello Brooklyn, we are on vacation on weekends and are not able to respond to messages. Raise the contract, delivery time of equipment to your warehouse in Rotterdam to 50 working ( not calendar) days. Action taken. 22/07/2024 06:21
Good day, tell me need delivery in Arlington to the settlement in the distance of 20 km. Can you organize this? 22/07/2024 06:30
Elijah, Good afternoon, please send us an email to info@minipress.ru with the exact name of the equipment model, city, and your coordinates. We will calculate the delivery to you. 22/07/2024 06:32
We received our order (BG-150 film coating boiler) in the box there was no spraying nozzle !!! 22/07/2024 06:40
Hello Andrew, we checked with the factory. Your nozzle was not received in time for the shipment of the main machine. We will now deliver it to you by DHL express mail. 22/07/2024 06:42
In Pilsen ITA-01 tablet and capsule counter, RZ-9 rotary tablet press and manual capsule filling machine. Help when we get it ? 22/07/2024 06:50
Good afternoon, Lucy! We have received from the factories photos of the equipment after packing. Natalia will forward the photos to you. Delivery time to you is 45-50 days. 22/07/2024 06:51
Vacuum powder conveyor QV-01 quantity of 3 pieces, need discount and delivery to New York. 22/07/2024 07:00
Good day Scarlett, in our catalog all prices are given including delivery to the door of the customer. If you buy 3 pieces we will make a discount of 7%. Delivery to New York is included in the price. 22/07/2024 07:01
Tell me the NJ-120 automatic capsule machine went ? 22/07/2024 07:10
Evelyn, good afternoon. Yes, already tomorrow until 18: 30 you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 22/07/2024 07:10
Good day, I want as agreed to get FF-02 tablet and capsule filling machine in Zagreb? 22/07/2024 07:20
Good afternoon, Michael! We have contacted the transportation company, your shipment is arriving in Zagreb without delay. Please wait for a call from a representative of Business Lines. 22/07/2024 07:20
I would like to discuss the purchase of model FK-05 - capping and screw cap machine. 22/07/2024 07:30
Good day. You can call on tel. +79853643808 or to the mail specified on the site. Chloe, this chat is only for tracking shipments. 22/07/2024 07:30
Contract #12, the deadline for delivery has already passed. Take action at last. Accelerate Tsibulsky R.G. 22/07/2024 07:40
Hello Ava, we are on vacation on weekends and are not able to respond to messages. Raise the contract, delivery time of equipment to your warehouse in Dubrovnik to 50 working ( not calendar) days. Action taken. 22/07/2024 07:43
Remember me? There's a delivery in the Cinque Terre 22/07/2024 07:50
Joseph, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be as stipulated in the contract in Cinque Terre . 22/07/2024 07:51
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC CARTONING MACHINES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS