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The disadvantages of spray drying method include contact of thermolabile material with hot drying agent, complexity and high cost of equipment for liquid dispersion and dust collection.
Spray drying has a well-established technology, but traditional spray drying produces only microparticles. Recently, new Techniques and improved equipment are being developed to carry out the spray drying process, the aim of which is to obtain nanosized particles.
For this purpose, the following two conditions must be met: reduce the initial droplet size; use solutions with low solid phase content. It is possible to reduce the droplet size by using new atomizing devices, such as ultrasonic atomizing devices that achieve droplet sizes of 3 µm and below, or electrospray, which gives even smaller droplets. The second condition, low solids content in the solution, ensures that the initial droplet size decreases significantly as the solution is dewatered, yielding nanometer-sized particles. For example, when drying an aqueous solution with solid phase concentration not more than 7 % and initial droplet size of 1.5 microns, it is possible to obtain particles of 100 nm.
Pharmaceutical Glossary
Technical specifications
The fluid supply is pressurized. The nozzle delivers the fluid continuously or intermittently. There are many ways to atomize the liquid.
The choice of type of atomizing device and its design are determined by the properties of the atomized liquid, the need to obtain a homogeneous atomizing plume of a certain dispersion, the required productivity, the degree of complexity of construction and maintenance, as well as the cost. The main indicators of nozzles are atomization rate of liquid, macrostructure (angle and length of the jet; spatial distribution of droplets) and microstructure (size of droplets and their size distribution). The principle of operation of a pneumatic nozzle is based on the fact that compressed air breaks the solution into individual small particles, which is ejected from the nozzle of the nozzle at high velocity and dispersed torch. The position of the nozzle during atomization can be adjusted. Spray dryers operate on the principle of direct current, counter current and mixed current. Design design of spray drying plants is determined by technological requirements (type of product, its thermal lability, viscosity of the liquid, etc.), type of atomizing device, capacity for evaporated moisture and other parameters. Cyclones 6 are used to clean the exhaust air sucked from the tower by the fan. Pumps inject material and air into the pneumatic nozzle (atomization is made in counterflow of the drying agent).
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Additional information
The process scheme is as follows: the solution or suspension to be dried is fed through a pneumatic nozzle into the drying chamber. The atomization process produces a large number of polydisperse droplets. The atomized particles have a large surface area, which results in intensive heat and mass transfer with the drying agent entering the chamber through the nozzle. They quickly lose moisture and in a few seconds spherical porous granules are formed from the suspended suspension of dewatered droplets, which fall to the bottom of the chamber and fall into a container for product collection. The granules have good friability and compressibility, so tablets produced from such granulate have high strength and compressibility at low pressures. Single-section, unidirectional (direct flow of suspension droplets relative to the coolant flow) dryers are also used in the spray granulation process, which will be discussed in the next section.
The specificity of the process determines a number of characteristic advantages of the spray drying method: high quality of the dry product; high intensity of heat and mass transfer between the dispersed material and the heat transfer gas, determined by the degree of dispersibility of the material, gas temperature and hydrodynamic features of the apparatus; possibility of process control; continuity of drying.
Order status tracking
Good day, delivery time of semi-automatic drum filling machine DF-10 to Thessaloniki, will the courier call us? 22/02/2025 06:27
Evelyn, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 22/02/2025 06:30
Good afternoon! semi-automatic liquid filling machine in barrels DF-13 , a copy of the payment is sent to the post. Start the order to work. 22/02/2025 06:37
Luna, good afternoon! We have seen your payment, we receive SMS from the bank. Please send drawings of barrels and answers to our questions in correspondence. 22/02/2025 06:40
How to contact you for shipment tracking ? Industrial vibrating screen VS-04. 22/02/2025 06:47
Good afternoon, Daniel, My WhastApp is +79853643808, Manager Natalia +79153808881 during business hours and except weekends. 22/02/2025 06:47
Rotary tablet press RZK-25 I want to order with delivery to Berlin 22/02/2025 06:57
Good day, Lucas We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 22/02/2025 06:58
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Sigissoara, but immediately upon arrival send it to Frankfurt. 22/02/2025 07:07
Hello Michael, we will try to resolve this issue for you. 22/02/2025 07:11
Please inform me about the status of the order Rotary tablet press RZ-10A in Atlanta ? 22/02/2025 07:17
Good afternoon, James. We have contacted the carrier, delivery is scheduled as agreed. Please let us know when you receive it. Thank you. 22/02/2025 07:21
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled tomorrow until 16:30 to open the box and test. 22/02/2025 07:27
Emma, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 22/02/2025 07:27
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Dubrovnik ? 22/02/2025 07:37
Hello John, Expect In the afternoon. Once received, please let us know. 22/02/2025 07:38
Hello Roman! Thank you for the service and quality of your products. We are very happy and satisfied with the purchase! 22/02/2025 07:47
Hello Aria, Apparently you have tested your vacuum lyophilic dryer LZY-01. Its quality is above average, it will work. We are waiting for your new applications. 22/02/2025 07:50
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to Baltimore. Thank you. 22/02/2025 07:57
Lucas, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to Baltimore is scheduled for closer to evening. Please notify us upon receipt. 22/02/2025 07:57
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR COATING TABLETS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- PERISTALTIC PUMPS DISPENSERS