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The disadvantages of spray drying method include contact of thermolabile material with hot drying agent, complexity and high cost of equipment for liquid dispersion and dust collection.
Spray drying has a well-established technology, but traditional spray drying produces only microparticles. Recently, new Techniques and improved equipment are being developed to carry out the spray drying process, the aim of which is to obtain nanosized particles.
For this purpose, the following two conditions must be met: reduce the initial droplet size; use solutions with low solid phase content. It is possible to reduce the droplet size by using new atomizing devices, such as ultrasonic atomizing devices that achieve droplet sizes of 3 µm and below, or electrospray, which gives even smaller droplets. The second condition, low solids content in the solution, ensures that the initial droplet size decreases significantly as the solution is dewatered, yielding nanometer-sized particles. For example, when drying an aqueous solution with solid phase concentration not more than 7 % and initial droplet size of 1.5 microns, it is possible to obtain particles of 100 nm.
Pharmaceutical Glossary
Technical specifications
The fluid supply is pressurized. The nozzle delivers the fluid continuously or intermittently. There are many ways to atomize the liquid.
The choice of type of atomizing device and its design are determined by the properties of the atomized liquid, the need to obtain a homogeneous atomizing plume of a certain dispersion, the required productivity, the degree of complexity of construction and maintenance, as well as the cost. The main indicators of nozzles are atomization rate of liquid, macrostructure (angle and length of the jet; spatial distribution of droplets) and microstructure (size of droplets and their size distribution). The principle of operation of a pneumatic nozzle is based on the fact that compressed air breaks the solution into individual small particles, which is ejected from the nozzle of the nozzle at high velocity and dispersed torch. The position of the nozzle during atomization can be adjusted. Spray dryers operate on the principle of direct current, counter current and mixed current. Design design of spray drying plants is determined by technological requirements (type of product, its thermal lability, viscosity of the liquid, etc.), type of atomizing device, capacity for evaporated moisture and other parameters. Cyclones 6 are used to clean the exhaust air sucked from the tower by the fan. Pumps inject material and air into the pneumatic nozzle (atomization is made in counterflow of the drying agent).
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Additional information
The process scheme is as follows: the solution or suspension to be dried is fed through a pneumatic nozzle into the drying chamber. The atomization process produces a large number of polydisperse droplets. The atomized particles have a large surface area, which results in intensive heat and mass transfer with the drying agent entering the chamber through the nozzle. They quickly lose moisture and in a few seconds spherical porous granules are formed from the suspended suspension of dewatered droplets, which fall to the bottom of the chamber and fall into a container for product collection. The granules have good friability and compressibility, so tablets produced from such granulate have high strength and compressibility at low pressures. Single-section, unidirectional (direct flow of suspension droplets relative to the coolant flow) dryers are also used in the spray granulation process, which will be discussed in the next section.
The specificity of the process determines a number of characteristic advantages of the spray drying method: high quality of the dry product; high intensity of heat and mass transfer between the dispersed material and the heat transfer gas, determined by the degree of dispersibility of the material, gas temperature and hydrodynamic features of the apparatus; possibility of process control; continuity of drying.
Order status tracking
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Tbilisi ? 22/01/2025 02:00
Hello Samuel, Expect in the interval from 14:00-16:00. Once received, please let us know. 22/01/2025 02:00
Dear Roman. Deadline (time) I am waiting for your quotation for a machine for removing tablets and capsules from blister packs MB-10 with delivery. 22/01/2025 02:10
Hello Abigail, By the specified time we will send the offer to your e-mail. Now we are waiting for an answer from the transportation company on the delivery time to San Antonio . 22/01/2025 02:12
The BB-152 liquid filling machine arrived from you today, remember us ? Where's the paperwork? 22/01/2025 02:20
{The original shipping documents will be delivered to Ljubljana tomorrow until 18: 30. Please send the signed copies to us. 22/01/2025 02:21
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled closer to evening to open the box and test. 22/01/2025 02:30
Elijah, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 22/01/2025 02:31
When purchasing the RY-200 centrifugal type powder granulator, I asked for tests on our powder 22/01/2025 02:40
Hello Amelia, Please send 2 kg of your raw material to the address given to you by Natalia. After the test, the engineer will inform you about the results. 22/01/2025 02:43
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Jurmala. 22/01/2025 02:50
Hello Noah, Delivery status checked, in the morning is arriving at Jurmala . The driver will call you beforehand. 22/01/2025 02:51
Horizontal granulator for organic fertilizers JU-80, the price is up to date ? Delivery time to Strasbourg? Urgent. 22/01/2025 03:00
Aiden, Please read carefully the description of this model in our catalog. Prices are current. Timing 1-1.5 months. 22/01/2025 03:01
Remember me? There's a delivery in the Crete 22/01/2025 03:10
Matthew, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be tomorrow until 15:30 in Crete . 22/01/2025 03:11
Roman hello, what about the automatic filling and sealing machine for sterile ampoules ABF-4D-1, invoice #101. 22/01/2025 03:20
Good afternoon, Victoria! We are making a request to the manufacturer. Tomorrow we will send photos and video of testing to your e-mail. 22/01/2025 03:22
RZW-29 rotary tablet press in Luxembourg City. Regards, Dylan. 22/01/2025 03:30
Dylan, Delivery will be made In the afternoon to Luxembourg City . Please have the movers ready. The weight of the equipment is heavy. 22/01/2025 03:31
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COATING TABLETS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC CARTONING MACHINES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC CARTONING MACHINES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES