TECNOLOGÍAS DE PRODUCCIÓN FARMACÉUTICA

Máquinas rotativas de comprimidos

7887

6493347

• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 

Rotary tablet machines (RTM), unlike eccentric ones, have a large number of matrices and punches. The matrices are mounted in a rotating matrix table. The pressure in the RTM increases gradually, which ensures a soft and uniform pressing of the tablets. rTMS have high productivity (up to 0.5 million tablets per hour). The technological cycle of tableting on RTM consists of a number of sequential operations: Filling the matrices with tableted material (volumetric dosing method). Actually pressing. Ejection. Dropping pills. The operations are performed sequentially in automatic mode. The upper and lower punches slide along the guides (caps) and pass between the pressing rollers, exerting simultaneous pressure on them. The pressure increases and decreases gradually, which leads to uniform and soft pressing of the tablet…

Requisitos básicos de las formas farmacéuticas blandas gmp

7831

6492779

• 
• 
• 
• 
• 
• 
• 

In the production of ointments, creams and other soft dosage forms, there is a particularly high risk of microbial and other contamination. Therefore, special measures are needed to prevent any contamination. Soft dosage forms have specific rheological properties and in most cases are heterogeneous dispersed systems. Therefore, in order to avoid heterogeneity of the product due to uneven distribution of components, formation of gas emulsions and destabilization of dispersed systems, special attention should be paid to the proper conduct of the technological process, the equipment used and the temperature conditions of product storage. Requirements for production facilities and equipment. The environment of the premises, taking into account all measures to protect production, should pose a minimal risk in terms of contamination of materials and products.

Método de secado por pulverización (método de microencapsulación fisicoquímica)

7902

6493495

• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 

The method of spray drying of the dispersion or emulsion of the encapsulated substance containing polymer and solvent (both organic and aqueous) consists in their dispersion into the flow of a coolant gas. As a result of heat and mass transfer, the solvent is removed from the system and dense particles are formed, the encapsulated substance in which is distributed throughout the volume, and not concentrated in the capsule core. The most widespread groups of substances used for encapsulation by spray drying are carbohydrates, including modified and hydrolyzed starches, cellulose derivatives, gums and cyclodextrins; proteins, including whey proteins, casein and gelatin; biopolymers. The type of shell material used affects not only the encapsulation efficiency, but also the morphology of the product particles.

Método de extrusión (método de microencapsulación física)

7905

6493526

• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 

During microencapsulation by extrusion, a thin viscous film of film-forming material is formed on the surface with small diameter holes, through which the encapsulated substance is pressed. The shell formed in this way is further stabilized by cooling or polymerization of its constituent monomers. For microencapsulation by extrusion, forming devices are also used, which are two coaxially arranged tubes of different diameters (a "pipe in a pipe" device). The encapsulated material is fed into the inner hole of the tube under pressure, and the shell material is fed into the inter—tube space.

Método basado en el uso de polímeros y agentes reticulantes.

7908

6493558

• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 

Crosslinking of polymer chains is carried out by introducing special substances into the system, which, as a result of ion exchange, form bonds between two neighboring chains. In this case, the process takes place at the interface of the phases. It is possible to use oil-in-water systems containing a hydrophilic polymer and, for example, lower aldehydes as crosslinking agents. In this case, the interaction of the polymer with the aldehyde occurs in the aqueous phase, resulting in the formation of a new phase deposited on oil droplets, since the higher aldehydes dissolve in the non-polar phase.

Equipos para procesos combinados

7886

6493338

• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 

The SG type apparatus manufactured by NPO "Pharmedobrazovanie" is used for granulation of powders in a fluidized bed, subsequent drying and dusting. This process is periodic. The body of the device is made of three all-welded sections, sequentially mounted with each other. The principle of operation is as follows: 30 kg of tablet mixture to be granulated is loaded into the food tank in accordance with the recipe. The trolley with the initial components is rolled into the machine and lifted. The air temperature required for fanulation is set, the mixing, fanulation and drying time is set, as well as the cyclicity and frequency of shaking of bag filters. The fan is turned on with the help of a gate that regulates the flow of...

Equipo para proceso de granulación húmeda

7885

6493327

• 
• 
• 
• 
• 
• 
• 
• 
• 
• 

The granulate is obtained in the process of granulation of wet mass on special granulator machines. The principle of operation of granulators is that the material is wiped with blades, springy wolves or other devices through a perforated cylinder or mesh. To ensure the wiping process, the machine must operate at an optimal mode without overload so that the wet mass passes freely through the holes of the cylinder or mesh. If the mass is sufficiently moistened and moderately plastic, then it does not seal the holes and the process goes without difficulty. If the mass is viscous and seals the holes, the machine works with overload and it is necessary to periodically turn off the motor and rinse the drum blades. The granulator contains...

Aplicación de revestimiento en lecho fluidizado

7757

6492041

• 
• 
• 
• 
• 
• 
• 

The application of film coatings is carried out in apparatuses for combined granulation, drying and coating processes. A distinctive feature is the lower location of the nozzle. There are two possible ways of organizing the process: applying a film coating directly to crystals or granules containing a medicinal substance; conducting a preliminary stage — layering the medicinal substance on inert particles (pellets are most often used), after which a film coating is applied. During the coating process, a layer of particles is placed in a fluidized bed apparatus.

Llenado de cápsulas de gelatina con polvos y gránulos

7733

6491808

• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 

The reproduction and accuracy of dosing depends on the characteristics of the filler, the filling method and the type of filling machine. Active substances for filling into solid gelatin capsules must meet the following requirements: the contents must be released from the capsule, providing high bioavailability; when using automatic filling machines, active substances must have certain physico-chemical and technological properties, such as: certain particle size and shape; the same particle size; mixing homogeneity; flowability (fluidity); moisture content; ability to form compactly under pressure. To fill solid gelatin capsules, machines of various companies are used, differing in performance, dosing accuracy and the structure of the dispenser.

Métodos de producción industrial de cápsulas de gelatina.

7723

6491707

• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 

There are three main methods of industrial production of gelatin capsules: immersion method, rotary matrix and drip. It should be noted that for the production of solid capsules, the dipping method has found wide application in industry, being essentially the only one. However, to obtain soft gelatin capsules (with drip sealing), the method is currently used only in laboratory conditions, as it is low-productivity and time-consuming. The stamping method, or rotary matrix, is used for the production of soft gelatin capsules and is the most rational for their production in industrial production. The principle of the method is to first obtain a gelatin tape, from which capsules are stamped on the rolls immediately after they are filled and sealed.