TECNOLOGÍAS DE PRODUCCIÓN FARMACÉUTICA

Cribado de polvo en producción

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7693119

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When grinding solid materials on the equipment discussed earlier, a homogeneous product is practically not obtained, Therefore, such an operation as sieving is necessary to separate larger particles. Sieving is an integral part of grinding to obtain a mixture with a certain granulometric composition. Sieving eliminates soft conglomerates of powders by rubbing them through perforated plates or sieves with a certain size of holes. Sieving, or screening, is the process of separating a mixture of grains of various sizes using sieves into two (or more) groups. The size of the grains passing through the sieve cells is characterized by a number. There are 16 different sieves, which correspond to 7 degrees of grinding.

Preparación de la base del supositorio

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7692932

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The stage of preparation of the suppository base begins with the weighing of its components. In the first stainless steel reactor with a steam jacket, paraffin is melted, in the second reactor, hydrofluid is melted by supplying steam to the steam jacket. The heated hydrofluid is pumped into a reactor with pre-melted paraffin. The mixture is heated to a temperature of 60-70 °With and add cocoa butter. In order to avoid changing the modification of cocoa butter, the heating should not exceed 70 ° C and be prolonged. After the base is completely melted, it is stirred for 40 minutes using a stirrer. In the finished base, the melting point and the time of complete deformation are determined.

Método de secado por pulverización (método de microencapsulación fisicoquímica)

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7693285

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The method of spray drying of the dispersion or emulsion of the encapsulated substance containing polymer and solvent (both organic and aqueous) consists in their dispersion into the flow of a coolant gas. As a result of heat and mass transfer, the solvent is removed from the system and dense particles are formed, the encapsulated substance in which is distributed throughout the volume, and not concentrated in the capsule core. The most widespread groups of substances used for encapsulation by spray drying are carbohydrates, including modified and hydrolyzed starches, cellulose derivatives, gums and cyclodextrins; proteins, including whey proteins, casein and gelatin; biopolymers. The type of shell material used affects not only the encapsulation efficiency, but also the morphology of the product particles.

Método de extrusión (método de microencapsulación física)

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7693316

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During microencapsulation by extrusion, a thin viscous film of film-forming material is formed on the surface with small diameter holes, through which the encapsulated substance is pressed. The shell formed in this way is further stabilized by cooling or polymerization of its constituent monomers. For microencapsulation by extrusion, forming devices are also used, which are two coaxially arranged tubes of different diameters (a "pipe in a pipe" device). The encapsulated material is fed into the inner hole of the tube under pressure, and the shell material is fed into the inter—tube space.

Método basado en el uso de polímeros y agentes reticulantes.

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7693348

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Crosslinking of polymer chains is carried out by introducing special substances into the system, which, as a result of ion exchange, form bonds between two neighboring chains. In this case, the process takes place at the interface of the phases. It is possible to use oil-in-water systems containing a hydrophilic polymer and, for example, lower aldehydes as crosslinking agents. In this case, the interaction of the polymer with the aldehyde occurs in the aqueous phase, resulting in the formation of a new phase deposited on oil droplets, since the higher aldehydes dissolve in the non-polar phase.

Equipos para procesos combinados

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7693128

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The SG type apparatus manufactured by NPO "Pharmedobrazovanie" is used for granulation of powders in a fluidized bed, subsequent drying and dusting. This process is periodic. The body of the device is made of three all-welded sections, sequentially mounted with each other. The principle of operation is as follows: 30 kg of tablet mixture to be granulated is loaded into the food tank in accordance with the recipe. The trolley with the initial components is rolled into the machine and lifted. The air temperature required for fanulation is set, the mixing, fanulation and drying time is set, as well as the cyclicity and frequency of shaking of bag filters. The fan is turned on with the help of a gate that regulates the flow of...

Aplicación de revestimiento en lecho fluidizado

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7691831

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The application of film coatings is carried out in apparatuses for combined granulation, drying and coating processes. A distinctive feature is the lower location of the nozzle. There are two possible ways of organizing the process: applying a film coating directly to crystals or granules containing a medicinal substance; conducting a preliminary stage — layering the medicinal substance on inert particles (pellets are most often used), after which a film coating is applied. During the coating process, a layer of particles is placed in a fluidized bed apparatus.

Llenado de cápsulas de gelatina con polvos y gránulos

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7691598

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The reproduction and accuracy of dosing depends on the characteristics of the filler, the filling method and the type of filling machine. Active substances for filling into solid gelatin capsules must meet the following requirements: the contents must be released from the capsule, providing high bioavailability; when using automatic filling machines, active substances must have certain physico-chemical and technological properties, such as: certain particle size and shape; the same particle size; mixing homogeneity; flowability (fluidity); moisture content; ability to form compactly under pressure. To fill solid gelatin capsules, machines of various companies are used, differing in performance, dosing accuracy and the structure of the dispenser.

Métodos de producción industrial de cápsulas de gelatina.

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7691497

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There are three main methods of industrial production of gelatin capsules: immersion method, rotary matrix and drip. It should be noted that for the production of solid capsules, the dipping method has found wide application in industry, being essentially the only one. However, to obtain soft gelatin capsules (with drip sealing), the method is currently used only in laboratory conditions, as it is low-productivity and time-consuming. The stamping method, or rotary matrix, is used for the production of soft gelatin capsules and is the most rational for their production in industrial production. The principle of the method is to first obtain a gelatin tape, from which capsules are stamped on the rolls immediately after they are filled and sealed.

Conceptos básicos de la tecnología de cápsulas de gelatina blanda

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7691764

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Soft gelatin capsules can also vary in capacity, although there is no clear standardization, unlike hard capsules. Suture soft capsules can hold up to 7.5 ml. The capacity of the rolls of the machine, with which the capsules are formed, filled and sealed, is measured in units called minim. At the same time, 1 minim is equal to an average of 0.062 ml, and the most commonly used roll cell sizes range from 2 to 80 minim. Larger capsules (up to 120 minim) have found application in the perfume industry.