TECNOLOGÍAS DE PRODUCCIÓN FARMACÉUTICA

Etapas de prensado para materiales en polvo

7925

6675807

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The whole pressing process is proposed to be divided into three stages: compaction (pre-pressing); formation of a compact body; volumetric compression of the resulting compact body. At the first stage of pressing, under the influence of an external force, the material particles converge and seal due to their displacement relative to each other and filling voids. The forces overcome in this case are insignificant, the seal becomes noticeable even at low pressures. The applied energy is mainly spent on overcoming internal (between particles) and external (between particles and matrix machines) friction.

Recubrimientos de película para aplicaciones de liberación modificada

7807

6674631

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Modified release film coatings can be applied to pharmaceutical products to achieve modification, control the release of a medicinal substance. All coatings on the kinetics of drug release can be divided into the following four types: Coatings that provide periodic release of LV (intermittent release). This type includes coatings resistant to the effects of gastric juice — intestinal soluble coatings. Coatings that provide instant release of LV. Coatings that provide a steady (continuous) release of LV. Coatings that provide delayed (delayed) release of LV. Let's look at each type of coatings in more detail. Coatings that provide periodic release of the medicinal substance. This type of coating provides a prolonged effect of the dosage form, when injected into the body, LV is released in portions,...

Recubrimientos que proporcionan liberación de sustancias medicinales

7807

6674633

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With this type of coating, the medicinal substance from the tablets can be released instantly. These types of coatings include polymers developed by BASF: polyvinyl alcohol (PVA), Kollicoat IR white and Kollicoat Protect. PVS-based films are very elastic, but the coating process is possible only in a narrow range of varying technological parameters. This polymer is rapidly dispersed in water during the preparation of the dispersion for the film coating, forms shiny, non-sticky and very flexible films that do not crack during storage. The addition of a plasticizer is not required to create a coating. Kollicoat IR can be replaced by GPMC and other coatings with immediate release of LV in new tablet preparations. The use of Kollicoat IR increases the cost-effectiveness of the coating...

Problems encountered during coating application

7811

6674666

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As in the case of sugar coatings, problems may arise after or during the application of the film coating. Tablets, Pellets and granules on which the coating is applied may not be strong enough or delaminate during the coating process. Due to the fact that film coatings are relatively thin, their ability to hide defects is significantly lower than that of sugar coating. When using a film coating, various problems may arise. One example is sticking, which occurs when the fluid flow rate exceeds the drying rate, which causes the gluing of tablets, pellets and granules and their further destruction.

Requisitos básicos para tabletas

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6675363

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The following requirements are imposed on tablets: dosing accuracy — uniformity (uniformity) of the distribution of the active substance in the tablet, the correctness of the weight of both the tablet itself and the medicinal substances included in it; mechanical strength — hardness, brittleness, fragility — characterize the quality of tablets; tablets must have sufficient strength to remain intact under mechanical influences during packaging, transportation and storage; disintegration or solubility — the ability to disintegrate or dissolve within the time limits established by the relevant scientific and technical documentation (NTD) for certain types of tablets. The accuracy of dosing depends on the uniformity of the tableted mass, which is ensured by careful mixing of medicinal and auxiliary substances and their uniform distribution in the total...

Organización de la producción moderna de ungüentos

7843

6674985

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General recommendations for the selection of pharmaceutical equipment. The right choice of equipment is one of the most important issues of the organization of modern industrial production. Reliable, optimally selected and well-proven equipment largely determines the quality of the manufactured product, its competitiveness, and is also a guarantee of the successful development of production as a whole. The selection of equipment (for the pre-modern production of pharmaceutical products is carried out on the basis of many criteria. First of all, the equipment must be designed and optimally suited for the technological processes of production of a particular pharmaceutical product. Usually, preference is given to production machines and installations that allow several technological operations to be carried out at once, since their structural elements and operating...

Orientación, descarga de cierre, limpieza de cápsulas

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6674572

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There are empty capsules in the capsule bin. The capsules move down into two magazines, are aligned by the sorting unit and lowered into the corresponding cells. At the first stage of this operation, the first (internal) one is loaded a row of capsules, on the second one — the second (external) one is loaded a number of capsules. After the capsule magazine there is a narrow calibration hole. Only geometrically correct capsules can pass through this hole. In case of irregular shaped capsules that are unable to pass through the calibration hole, the cells are blocked, recognized by the scanner and excluded from the further filling process.

Proceso de producción de leucoplastos

7885

6675407

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A band-Aid (Leucoplastrum), or a sticky elastic band-aid smeared (Emplastrum adhaesivum elasticum externum). It is used to hold bandages, to bring the edges of wounds closer together, to stretch the limb in case of fracture, etc. It consists of the following components: 25.7 parts of natural rubber, 20.35 parts of rosin, 32 parts of zinc oxide, 9.9 parts of anhydrous lanolin, 11.3 parts of liquid paraffin and 0.75 parts of neozone D. The adhesive plaster production process includes several stages: the dissolution of natural rubber and rosin in gasoline, the preparation of an alloy of lanolin with liquid paraffin, mixing it with finely ground zinc oxide and the preparation of a paste of anti-oxidant rubber. The application of the finished mass of adhesive plaster to...

Producción de cápsulas de gelatina dura

7805

6674605

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As noted above, encapsulated dosage forms are becoming increasingly important due to their obvious advantages over other dosage forms. This section will consider the technology of production of solid gelatin capsules, which are most widely used in the modern pharmaceutical industry, as well as the equipment on which their manufacture is carried out. Characteristics of the main and auxiliary substances included in the composition of solid gelatin capsules. To obtain capsule shells, film-forming high-molecular substances capable of forming elastic films characterized by a certain mechanical strength are used. Such materials include casein, zein, cellulose esters and esters, fats and wax-like substances, as well as some synthetic polymers (for example, a copolymer of methacrylamide and methacrylic acid, etc.). However, these substances have not found wide practical...

Fabricación de parches de pimiento

7885

6675408

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Pepper plaster (EmplastrumCapsici) is a homogeneous sticky mass of yellow-brown color with a peculiar smell, applied to a fabric and covered with a protective layer of cellophane. Currently, a wide range of patches of various sizes is available: 12x18 cm, 10x18 cm, 8x18 cm, 10x15 cm, 4x10 cm, 6x10 cm, etc.The pepper patch has the following composition: 8% thick extract of capsicum, 0.6% thick extract of belladonna, 0.6% tincture of arnica, 22% natural rubber, 21% pine rosin, 18% anhydrous lanolin, 24% petroleum jelly oil and other components.