[vc_row][vc_column][vc_column_text]<\/p>\n
[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]\u00a0\r\n\r\nDirect<\/span> pressing<\/span> is<\/span> the<\/span> process<\/span> of<\/span> pressing<\/span> non\u2014granulated<\/span> powders.<\/span> From<\/span> the<\/span> technological<\/span> scheme<\/span> for<\/span> obtaining<\/span> tablets,<\/span> it<\/span> can<\/span> be<\/span> seen<\/span> that<\/span> direct<\/span> pressing<\/span> allows<\/span> you<\/span> to<\/span> exclude<\/span> 3-4<\/span> technological<\/span> operations<\/span> from<\/span> the<\/span> production<\/span> process.<\/span> The<\/span> direct<\/span> pressing<\/span> method<\/span> has<\/span> a<\/span> number<\/span> of<\/span> advantages,<\/span> including:<\/span> reduction<\/span> of<\/span> the<\/span> production<\/span> cycle<\/span> time<\/span> due<\/span> to<\/span> the<\/span> abolition<\/span> of<\/span> a<\/span> number<\/span> of<\/span> operations<\/span> and<\/span> stages;<\/span> use<\/span> of<\/span> less<\/span> equipment;<\/span> reduction<\/span> of<\/span> production<\/span> areas;<\/span> reduction<\/span> of<\/span> energy<\/span> and<\/span> labor<\/span> costs;<\/span> production<\/span> of<\/span> tablets<\/span> from<\/span> moisture-,<\/span> thermolabile<\/span> materials<\/span> and<\/span> incompatible<\/span> substances.<\/span> The<\/span> disadvantages<\/span> of<\/span> the<\/span> direct<\/span> pressing<\/span> method<\/span> include:<\/span> the<\/span> possibility<\/span> of<\/span> delamination<\/span> of<\/span> the<\/span> tablet<\/span> mass;<\/span> changing<\/span> the<\/span> dosage<\/span> when<\/span> pressing<\/span> with<\/span> a<\/span> small<\/span> amount<\/span> of<\/span> active<\/span> substances;<\/span> the<\/span> need<\/span> to<\/span> use<\/span> high<\/span> pressure.<\/span> Some<\/span> of<\/span> these<\/span> disadvantages<\/span> are<\/span> minimized<\/span> when<\/span> tableting<\/span> by<\/span> forcibly<\/span> feeding<\/span> the<\/span> pressed<\/span> substances<\/span> into<\/span> the<\/span> matrix.<\/span>\r\nJednak pomimo szeregu zalet, bezpo\u015brednie prasowanie powoli wprowadza si\u0119 do produkcji. Wynika to z faktu, \u017ce dla wydajnej pracy tabletkarek prasowany materia\u0142 musi mie\u0107 optymalne cechy technologiczne, a mianowicie: izodiametryczny kszta\u0142t kryszta\u0142\u00f3w, dobr\u0105 p\u0142ynno\u015b\u0107 (co najmniej 5-6 g\/s), wysok\u0105 \u015bci\u015bliwo\u015b\u0107 (co najmniej 0,4\u20140,5 g\/ml) i nisk\u0105 zdolno\u015b\u0107 przylegania do narz\u0119dzia prasy tabletkarki. Takie cechy posiada niewielka liczba nieuregulowanych proszk\u00f3w: bromki, chlorek sodu, jodek potasu, kwas acetylosalicylowy i niekt\u00f3re inne preparaty maj\u0105ce izodiametryczny (r\u00f3wnoosiowy) kszta\u0142t cz\u0105stek o mniej wi\u0119cej takim samym sk\u0142adzie granulometrycznym i z regu\u0142y nie zawieraj\u0105ce du\u017cej liczby ma\u0142ych frakcji. Proszki o wielko\u015bci cz\u0105stek 0,5\u20141 mm i porowato\u015bci 37% najlepiej nadaj\u0105 si\u0119 do bezpo\u015bredniego prasowania. Na przyk\u0142ad, aby uzyska\u0107 tabletki chlorku sodu, dopuszczalny jest pod\u0142u\u017cny kszta\u0142t cz\u0105stek, a okr\u0105g\u0142y kszta\u0142t tej substancji jest prawie niemo\u017cliwy do sprasowania. Najlepsz\u0105 p\u0142ynno\u015b\u0107 obserwuje si\u0119 w przypadku gruboziarnistych proszk\u00f3w o kszta\u0142cie cz\u0105stek r\u00f3wnoosiowych i niskiej porowato\u015bci, takich jak laktoza, salicylan fenylowy i inne podobne preparaty. Takie preparaty mo\u017cna kompresowa\u0107 bez wcze\u015bniejszej granulacji. \u0141\u0105czy je zdolno\u015b\u0107 do r\u00f3wnomiernego wysypywania si\u0119 z lejka pod wp\u0142ywem w\u0142asnej masy, tj. zdolno\u015b\u0107 do spontanicznego dozowania, a tak\u017ce do\u015b\u0107 dobra kompresowalno\u015b\u0107.\r\n\r\n\u00a0[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]<\/span><\/span><\/pre>\n[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] [\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]\u00a0 Direct pressing is the process of pressing non\u2014granulated powders. From the technological scheme for obtaining tablets, it can be seen that direct pressing allows you to exclude 3-4 technological operations from the production process. The direct pressing method has a number of advantages, including: reduction of the production cycle time due to the…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false},"categories":[2226,2175],"tags":[2380,2227,2372,2376,2381,2378,2377,2370,43,2373,2230,2379,95,90,2229,2375,119,2374,39,2371,212,89,91,2228,96],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Autor Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/sprzet-farmaceutyczny\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"PODSTAWY PRASOWANIA PROSZKU W TABLETKI<\/a> TECHNOLOGIE PRODUKCJI FARMACEUTYCZNEJ<\/a>","rttpg_excerpt":"[vc_row][vc_column][vc_column_text] [\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]\u00a0 Direct pressing is the process of pressing non\u2014granulated powders. From the technological scheme for obtaining tablets, it can be seen that direct pressing allows you to exclude 3-4 technological operations from the production process. The direct pressing method has a number of advantages, including: reduction of the production cycle time due to the...","_links":{"self":[{"href":"https:\/\/minipress.ru\/sprzet-farmaceutyczny\/wp-json\/wp\/v2\/posts\/59392"}],"collection":[{"href":"https:\/\/minipress.ru\/sprzet-farmaceutyczny\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/sprzet-farmaceutyczny\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/sprzet-farmaceutyczny\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/sprzet-farmaceutyczny\/wp-json\/wp\/v2\/comments?post=59392"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/sprzet-farmaceutyczny\/wp-json\/wp\/v2\/posts\/59392\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/sprzet-farmaceutyczny\/wp-json\/wp\/v2\/media?parent=59392"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/sprzet-farmaceutyczny\/wp-json\/wp\/v2\/categories?post=59392"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/sprzet-farmaceutyczny\/wp-json\/wp\/v2\/tags?post=59392"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}