{"id":59960,"date":"2024-01-16T15:24:10","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=59960"},"modified":"2024-01-16T15:24:10","modified_gmt":"1970-01-01T00:00:00","slug":"technological-properties-of-powdered-medicine-substances","status":"publish","type":"post","link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/technologies-and-equipment-for-the-production-of-powders\/technological-properties-of-powdered-medicine-substances\/","title":{"rendered":"Technological properties of powdered medicine substances"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]<\/span>\n\nThe<\/span> technological<\/span> properties<\/span> of<\/span> powdered<\/span> medicinal<\/span> substances<\/span> depend<\/span> on<\/span> their<\/span> physico-chemical<\/span> properties.<\/span> Fractional<\/span> (granulometric)<\/span> composition<\/span> is<\/span> the<\/span> distribution<\/span> of<\/span> powder<\/span> particles<\/span> by<\/span> size.<\/span> The<\/span> fractional<\/span> composition<\/span> has<\/span> a<\/span> certain<\/span> effect<\/span> on<\/span> the<\/span> degree<\/span> of<\/span> flowability,<\/span> therefore,<\/span> on<\/span> the<\/span> rhythmic<\/span> operation<\/span> of<\/span> tablet<\/span> machines,<\/span> on<\/span> the<\/span> stability<\/span> of<\/span> the<\/span> mass<\/span> of<\/span> the<\/span> tablets<\/span> obtained,<\/span> the<\/span> accuracy<\/span> of<\/span> the<\/span> dosage<\/span> of<\/span> LV,<\/span> on<\/span> the<\/span> qualitative<\/span> characteristics<\/span> of<\/span> tablets<\/span> (appearance,<\/span> disintegration,<\/span> strength,<\/span> etc.).<\/span> Studies<\/span> of<\/span> the<\/span> fractional<\/span> composition<\/span> of<\/span> pharmaceutical<\/span> powders<\/span> to<\/span> be<\/span> tableted<\/span> have<\/span> shown<\/span> that<\/span> most<\/span> of<\/span> them<\/span> contain<\/span> a<\/span> fine<\/span> fraction<\/span> (less<\/span> than<\/span> 20<\/span> microns)<\/span> and<\/span> therefore<\/span> have<\/span> poor<\/span> flowability.<\/span>\nThey<\/span> are<\/span> poorly<\/span> dosed<\/span> by<\/span> volume<\/span> on<\/span> tablet<\/span> machines,<\/span> tablets<\/span> are<\/span> obtained<\/span> differently<\/span> in<\/span> weight<\/span> and<\/span> strength.<\/span> The<\/span> fractional<\/span> composition<\/span> of<\/span> powders<\/span> can<\/span> be<\/span> changed<\/span> by<\/span> directional<\/span> granulation,<\/span> which<\/span> allows<\/span> to<\/span> obtain<\/span> a<\/span> certain<\/span> number<\/span> of<\/span> large<\/span> fractions.<\/span>\nGranular<\/span> powders<\/span> usually<\/span> have<\/span> a<\/span> lumpy<\/span> appearance<\/span> with<\/span> a<\/span> relatively<\/span> equiaxed<\/span> shape<\/span> and,<\/span> as<\/span> a<\/span> rule,<\/span> contain<\/span> a<\/span> large<\/span> percentage<\/span> of<\/span> the<\/span> smallest<\/span> particles<\/span> (less<\/span> than<\/span> 50<\/span> microns).This<\/span> is<\/span> explained<\/span> by<\/span> the<\/span> technology<\/span> of<\/span> granulating<\/span> wet<\/span> material,<\/span> which<\/span> provides<\/span> for<\/span> repeated<\/span> mixing<\/span> and<\/span> dusting.<\/span> When<\/span> mixing<\/span> and<\/span> powdering,<\/span> a<\/span> large<\/span> number<\/span> of<\/span> small<\/span> particles<\/span> are<\/span> not<\/span> only<\/span> introduced<\/span> into<\/span> the<\/span> mixture,<\/span> but<\/span> it<\/span> is<\/span> also<\/span> crushed.<\/span>\nNon-granulated<\/span> powders<\/span> are<\/span> characterized<\/span> by<\/span> a<\/span> polyfractive<\/span> composition<\/span> and<\/span> a<\/span> complex<\/span> shape.<\/span> The<\/span> average<\/span> particle<\/span> size<\/span> of<\/span> non\u2014granulated<\/span> powders<\/span> is<\/span> 30-<\/span> 120<\/span> microns.<\/span>\nAs<\/span> practice<\/span> shows,<\/span> for<\/span> pharmaceutical<\/span> production,<\/span> the<\/span> characteristic<\/span> of<\/span> all<\/span> significant<\/span> powder<\/span> fractions<\/span> is<\/span> more<\/span> indicative<\/span> in<\/span> order<\/span> to<\/span> draw<\/span> a<\/span> conclusion<\/span> about<\/span> the<\/span> possibility<\/span> of<\/span> its<\/span> use<\/span> in<\/span> the<\/span> technology<\/span> of<\/span> a<\/span> particular<\/span> medicine.<\/span>\nFor<\/span> example,<\/span> the<\/span> fractional<\/span> composition<\/span> of<\/span> substances<\/span> used<\/span> in<\/span> the<\/span> production<\/span> was<\/span> determined<\/span> by<\/span> microscopy<\/span> (particles<\/span> of<\/span> less<\/span> than<\/span> 100<\/span> microns<\/span> in<\/span> size)<\/span> and<\/span> sieve<\/span> analysis<\/span> (particles<\/span> of<\/span> more<\/span> than<\/span> 100<\/span> microns<\/span> in<\/span> size)<\/span> with<\/span> the<\/span> help<\/span> of<\/span> studies<\/span> conducted<\/span> at<\/span> JSC<\/span> \"Chemical<\/span> and<\/span> Pharmaceutical<\/span> Combine<\/span> \"AKRIKHIN\".<\/span> When<\/span> using<\/span> sieve<\/span> analysis,<\/span> the<\/span> test<\/span> material<\/span> is<\/span> divided<\/span> into<\/span> fractions<\/span> by<\/span> sieving<\/span> through<\/span> a<\/span> standard<\/span> set<\/span> of<\/span> sieves<\/span> for<\/span> 5<\/span> minutes,<\/span> and<\/span> then<\/span> the<\/span> mass<\/span> of<\/span> each<\/span> fraction<\/span> and<\/span> its<\/span> percentage<\/span> are<\/span> found.<\/span>\n\n[\/vc_column_text][\/vc_column][\/vc_row]<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] The technological properties of powdered medicinal substances depend on their physico-chemical properties. Fractional (granulometric) composition is the distribution of powder particles by size. The fractional composition has a certain effect on the degree of flowability, therefore, on the rhythmic operation of tablet machines, on the stability of the mass of the tablets obtained, the…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"two_page_speed":[]},"categories":[2243],"tags":[2380,2381,2372,2376,2373,263,2378,2374,73,43,2377,2370,40,2191,2379,67,2230,119,2375,2371,2262,2270,66],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Author Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"TECHNOLOGIES AND EQUIPMENT FOR THE PRODUCTION OF POWDERS<\/a>","rttpg_excerpt":"[vc_row][vc_column][vc_column_text] The technological properties of powdered medicinal substances depend on their physico-chemical properties. Fractional (granulometric) composition is the distribution of powder particles by size. The fractional composition has a certain effect on the degree of flowability, therefore, on the rhythmic operation of tablet machines, on the stability of the mass of the tablets obtained, the...","_links":{"self":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/59960"}],"collection":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/comments?post=59960"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/59960\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/media?parent=59960"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/categories?post=59960"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/tags?post=59960"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}