{"id":59835,"date":"2024-01-16T13:20:35","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=59835"},"modified":"2024-01-18T15:22:09","modified_gmt":"2024-01-18T12:22:09","slug":"powder-production-operations-and-equipment-used","status":"publish","type":"post","link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/technologies-and-equipment-for-the-production-of-powders\/powder-production-operations-and-equipment-used\/","title":{"rendered":"Powder production operations and equipment used"},"content":{"rendered":"
The<\/span> technological<\/span> scheme<\/span> of<\/span> powder<\/span> production<\/span> includes<\/span> the<\/span> following<\/span> operations:<\/span> grinding,<\/span> sieving,<\/span> mixing<\/span> (in<\/span> the<\/span> manufacture<\/span> of<\/span> complex<\/span> powders),<\/span> dosing<\/span> (packing)<\/span> and<\/span> packaging.<\/span> The<\/span> need<\/span> to<\/span> perform<\/span> certain<\/span> technological<\/span> operations<\/span> depends<\/span> on<\/span> the<\/span> prescription,<\/span> medical<\/span> purpose<\/span> and<\/span> type<\/span> of<\/span> starting<\/span> preparations.<\/span> If<\/span> the<\/span> starting<\/span> materials<\/span> (medicinal<\/span> and<\/span> auxiliary<\/span> substances)<\/span> do<\/span> not<\/span> meet<\/span> the<\/span> required<\/span> fractional<\/span> composition<\/span> specified<\/span> in<\/span> the<\/span> regulations,<\/span> they<\/span> are<\/span> crushed.<\/span> Grinding<\/span> refers<\/span> to<\/span> the<\/span> mechanical<\/span> process<\/span> of<\/span> dividing<\/span> pieces<\/span> of<\/span> solids<\/span> into<\/span> smaller<\/span> ones<\/span> or<\/span> turning<\/span> them<\/span> into<\/span> powder,<\/span> as<\/span> a<\/span> result<\/span> of<\/span> which<\/span> the<\/span> surface<\/span> of<\/span> the<\/span> processed<\/span> material<\/span> increases<\/span> significantly,<\/span> which<\/span> significantly<\/span> accelerates<\/span> the<\/span> dissolution<\/span> of<\/span> medicinal<\/span> substances.<\/span> The<\/span> goals<\/span> of<\/span> grinding<\/span> are<\/span> as<\/span> follows:<\/span> to<\/span> provide<\/span> a<\/span> rapid<\/span> therapeutic<\/span> effect<\/span> by<\/span> reducing<\/span> the<\/span> particle<\/span> size<\/span> and<\/span> increasing<\/span> the<\/span> amount<\/span> of<\/span> substance;<\/span> to<\/span> obtain<\/span> a<\/span> uniform<\/span> powder<\/span> mixture;<\/span> to<\/span> ensure<\/span> the<\/span> accuracy<\/span> of<\/span> dosing<\/span> when<\/span> dividing<\/span> the<\/span> powder<\/span> mass<\/span> into<\/span> separate<\/span> doses;<\/span> to<\/span> obtain<\/span> a<\/span> semi-finished<\/span> product<\/span> used<\/span> by<\/span> the<\/span> enterprise<\/span> for<\/span> the<\/span> manufacture<\/span> of<\/span> solutions,<\/span> extracts,<\/span> tablets.<\/span> The<\/span> main<\/span> goal<\/span> of<\/span> the<\/span> grinding<\/span> stage<\/span> is<\/span> to<\/span> achieve<\/span> a<\/span> faster<\/span> and<\/span> more<\/span> complete<\/span> therapeutic<\/span> effect<\/span> by<\/span> reducing<\/span> the<\/span> particle<\/span> size<\/span> and<\/span> increasing<\/span> their<\/span> number.<\/span> Grinding<\/span> is<\/span> necessary<\/span> not<\/span> only<\/span> to<\/span> achieve<\/span> a<\/span> greater<\/span> therapeutic<\/span> effect,<\/span> but<\/span> also<\/span> for<\/span> more<\/span> accurate<\/span> dosing:<\/span> when<\/span> grinding,<\/span> the<\/span> particle<\/span> size<\/span> of<\/span> medicinal<\/span> substances<\/span> is<\/span> leveled,<\/span> after<\/span> which<\/span> they<\/span> mix<\/span> well<\/span> and<\/span> do<\/span> not<\/span> delaminate<\/span> during<\/span> dosing.<\/span> It<\/span> is<\/span> known<\/span> that<\/span> with<\/span> a<\/span> decrease<\/span> in<\/span> the<\/span> particle<\/span> size,<\/span> the<\/span> surface<\/span> energy<\/span> of<\/span> the<\/span> crushed<\/span> medicinal<\/span> substance<\/span> increases<\/span> sharply.<\/span> With<\/span> fine<\/span> grinding,<\/span> LV<\/span> dissolves<\/span> better,<\/span> participates<\/span> faster<\/span> and<\/span> more<\/span> fully<\/span> in<\/span> chemical<\/span> reactions.<\/span> Grinding<\/span> can<\/span> significantly<\/span> affect<\/span> the<\/span> therapeutic<\/span> activity<\/span> of<\/span> LV<\/span> due<\/span> to<\/span> changes<\/span> in<\/span> their<\/span> absorption<\/span> processes.<\/span> This<\/span> happens<\/span> when<\/span> the<\/span> solubility<\/span> of<\/span> LV<\/span> changes,<\/span> the<\/span> rate<\/span> of<\/span> which<\/span> is<\/span> directly<\/span> proportional<\/span> to<\/span> the<\/span> surface<\/span> area<\/span> and<\/span> inversely<\/span> proportional<\/span> to<\/span> the<\/span> size<\/span> of<\/span> the<\/span> particles<\/span> of<\/span> the<\/span> substance,<\/span> i.e.<\/span> the<\/span> rate<\/span> and<\/span> completeness<\/span> of<\/span> absorption<\/span> of<\/span> the<\/span> medicinal<\/span> substance,<\/span> its<\/span> concentration<\/span> and<\/span> residence<\/span> time<\/span> in<\/span> the<\/span> body<\/span> largely<\/span> depend<\/span> on<\/span> the<\/span> particle<\/span> size.<\/span>\n<\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
The technological scheme of powder production includes the following operations: grinding, sieving, mixing (in the manufacture of complex powders), dosing (packing) and packaging. The need to perform certain technological operations depends on the prescription, medical purpose and type of starting preparations. If the starting materials (medicinal and auxiliary substances) do not meet the required fractional…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"two_page_speed":[]},"categories":[3689,2243],"tags":[2380,2381,2372,2376,2373,263,2378,2374,43,2377,2370,220,230,227,2379,229,2230,119,2375,116,2371,2262,2265],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Author Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"HORIZONTAL PACKAGING MACHINES PRICE<\/a> TECHNOLOGIES AND EQUIPMENT FOR THE PRODUCTION OF POWDERS<\/a>","rttpg_excerpt":"The technological scheme of powder production includes the following operations: grinding, sieving, mixing (in the manufacture of complex powders), dosing (packing) and packaging. The need to perform certain technological operations depends on the prescription, medical purpose and type of starting preparations. If the starting materials (medicinal and auxiliary substances) do not meet the required fractional...","_links":{"self":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/59835"}],"collection":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/comments?post=59835"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/59835\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/media?parent=59835"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/categories?post=59835"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/tags?post=59835"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}